I-kappa B Proteins

"I-kappa B Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

Descriptor ID	D020672
MeSH Number(s)	D12.644.360.365 D12.776.260.420 D12.776.476.381 D12.776.930.326
Concept/Terms	I-kappa B Proteins I-kappa B Proteins I kappa B Proteins I kappa B IkB DNA-Binding Proteins IkB DNA Binding Proteins I-kappa B

Below are MeSH descriptors whose meaning is more general than "I-kappa B Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Proteins [D12.644.360.365]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
I-kappa B Proteins [D12.776.260.420]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Proteins [D12.776.476.381]
Transcription Factors [D12.776.930]
I-kappa B Proteins [D12.776.930.326]

Below are MeSH descriptors whose meaning is related to "I-kappa B Proteins".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Proteins".

I-kappa B Proteins
NF-KappaB Inhibitor alpha

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Proteins" by people in this website by year, and whether "I-kappa B Proteins" was a major or minor topic of these publications.

Bar chart showing 38 publications over 18 distinct years, with a maximum of 5 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	0	2
1999	1	0	1
2000	2	0	2
2001	1	1	2
2002	3	0	3
2003	2	2	4
2004	2	3	5
2005	0	4	4
2006	1	3	4
2007	0	1	1
2008	0	1	1
2009	1	0	1
2011	0	1	1
2013	0	2	2
2014	0	1	1
2015	0	1	1
2019	1	1	2
2024	0	1	1

Below are the most recent publications written about "I-kappa B Proteins" by people in Profiles.

Zhu N, Rogers WE, Heidary DK, Huxford T. Structural and biochemical analyses of the nuclear I?B? protein in complex with the NF-?B p50 homodimer. Genes Dev. 2024 Jul 19; 38(11-12):528-535.

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Li P, Zhao G, Ding Y, Wang T, Flores J, Ocak U, Wu P, Zhang T, Mo J, Zhang JH, Tang J. Rh-IFN-a attenuates neuroinflammation and improves neurological function by inhibiting NF-?B through JAK1-STAT1/TRAF3 pathway in an experimental GMH rat model. Brain Behav Immun. 2019 07; 79:174-185.

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Mulero MC, Huxford T, Ghosh G. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226.

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Kusko RL, Brothers JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 10 15; 194(8):948-960.

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Simmons LJ, Surles-Zeigler MC, Li Y, Ford GD, Newman GD, Ford BD. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation. 2016 09 06; 13(1):237.

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Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR. Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. Inflamm Bowel Dis. 2015 Sep; 21(9):2005-15.

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Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity. J Cell Physiol. 2014 Jun; 229(6):762-71.

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Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod. 2014 Mar 28; 77(3):527-35.

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Thota C, Laknaur A, Farmer T, Ladson G, Al-Hendy A, Ismail N. Vitamin D regulates contractile profile in human uterine myometrial cells via NF-?B pathway. Am J Obstet Gynecol. 2014 Apr; 210(4):347.e1-347.e10.

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Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, Klimstra DS, Zhu LJ, Simin K, Xu L, McMahon AP, Lewis BC, Mao J. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47.

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