"Mucin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
| Descriptor ID |
D055264
|
| MeSH Number(s) |
D12.644.360.534 D12.776.395.560.631.195 D12.776.476.534
|
| Concept/Terms |
Mucin-4 alpha chain- Mucin-4 alpha chain
- Mucin 4 alpha chain
- Ascites Sialoglycoprotein 1
- Sialoglycoprotein 1, Ascites
- ASGP-1
|
Below are MeSH descriptors whose meaning is more general than "Mucin-4".
Below are MeSH descriptors whose meaning is more specific than "Mucin-4".
This graph shows the total number of publications written about "Mucin-4" by people in this website by year, and whether "Mucin-4" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mucin-4" by people in Profiles.
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Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res. 2008 Apr 01; 68(7):2065-70.
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Andrianifahanana M, Chauhan SC, Choudhury A, Moniaux N, Brand RE, Sasson AA, Pour PM, Batra SK. MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications. Am J Gastroenterol. 2006 Oct; 101(10):2319-29.
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Chauhan SC, Singh AP, Ruiz F, Johansson SL, Jain M, Smith LM, Moniaux N, Batra SK. Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). Mod Pathol. 2006 Oct; 19(10):1386-94.
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Singh AP, Chauhan SC, Bafna S, Johansson SL, Smith LM, Moniaux N, Lin MF, Batra SK. Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. Prostate. 2006 Mar 01; 66(4):421-9.
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Moniaux N, Varshney GC, Chauhan SC, Copin MC, Jain M, Wittel UA, Andrianifahanana M, Aubert JP, Batra SK. Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem. 2004 Feb; 52(2):253-61.
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Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res. 2004 Jan 15; 64(2):622-30.