Intracellular Signaling Peptides and Proteins

"Intracellular Signaling Peptides and Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.

Descriptor ID	D047908
MeSH Number(s)	D12.644.360 D12.776.476
Concept/Terms	Intracellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Intracellular Signaling Peptides Intracellular Signaling Peptides Peptides, Intracellular Signaling Signaling Peptides, Intracellular Intracellular Signaling Proteins Intracellular Signaling Proteins Proteins, Intracellular Signaling Signaling Proteins, Intracellular

Below are MeSH descriptors whose meaning is more general than "Intracellular Signaling Peptides and Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]

Below are MeSH descriptors whose meaning is related to "Intracellular Signaling Peptides and Proteins".

Below are MeSH descriptors whose meaning is more specific than "Intracellular Signaling Peptides and Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Intracellular Signaling Peptides and Proteins" by people in this website by year, and whether "Intracellular Signaling Peptides and Proteins" was a major or minor topic of these publications.

Bar chart showing 178 publications over 29 distinct years, with a maximum of 15 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	2	0	2
1999	1	1	2
2000	0	3	3
2001	0	3	3
2002	3	5	8
2003	10	5	15
2004	5	7	12
2005	3	9	12
2006	5	5	10
2007	3	3	6
2008	2	3	5
2009	2	2	4
2010	5	7	12
2011	4	7	11
2012	4	4	8
2013	2	5	7
2014	0	10	10
2015	2	5	7
2016	0	5	5
2017	0	3	3
2018	1	5	6
2019	6	5	11
2020	3	3	6
2021	1	0	1
2022	1	0	1
2023	0	3	3
2024	1	1	2
2025	2	0	2

Below are the most recent publications written about "Intracellular Signaling Peptides and Proteins" by people in Profiles.

Xiong Z, Kong Q, Chagantipati B, Stepniak A, Jaswal AP, Sneiderman CT, Han Y, Jackson SA, Raphael RA, Zhang W, Li M, Chao Y, Qin B, Dulkadir Z, Schwegman L, Zhang Y, Kuminkoski C, Mahlke MA, Nath P, Hu B, Zinn PO, Mantica M, Agnihotri S, Nechemia-Arbely Y, Pollack IF, Rigatti LH, Forsthuber TG, Li X, Raphael I, Kohanbash G. C/EBP?-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma. Cell Mol Immunol. 2026 Jan; 23(1):94-113.

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Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J. A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin. Nucleic Acids Res. 2025 Jul 08; 53(13).

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Nunes LGA, Weingrill RB, Fredrick SBJ, Lorca R, Lee MJ, Atif SM, Chicco AJ, Rosario FJ, Urschitz J. Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice. Acta Physiol (Oxf). 2025 Apr; 241(4):e70012.

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Yuan Y, Yang X, Zhao Y, Flores JJ, Huang L, Gu L, Li R, Zhang X, Zhu S, Dong S, Kanamaru H, He Q, Tao Y, Yi K, Han M, Chen X, Wu L, Zhang JH, Xie Z, Tang J. Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage. J Cereb Blood Flow Metab. 2025 Mar; 45(3):510-527.

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Nakayama Y, Kobayashi S, Masihuddin A, Abdali SA, Seneviratne AMPB, Ishii S, Iida J, Liang Q, Yoshioka J. Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes. Circ Res. 2024 Jul 19; 135(3):416-433.

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Anchoori RK, Anchoori V, Lam B, Tseng SH, Das S, Velasquez FC, Karanam B, Poddatoori D, Patnam R, Rudek MA, Chang YN, Roden RBS. Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor. PLoS One. 2023; 18(6):e0285221.

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Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, Lee JR, Salem F, Mariani LH, Gordon RE, Basgen JM, Wen HH, Fu J, Azeloglu EU, He JC, Wong JS, Campbell KN. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight. 2023 04 10; 8(7).

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Kim S, Ochoa K, Melli SE, Yousufzai FAK, Barrera ZD, Williams AA, McIntyre G, Delgado E, Bolish JN, Macleod CM, Boghos M, Lens HP, Ramos AG, Wilson VB, Maloney K, Padron ZM, Khan AH, Blanco RE, Soto I. Disruptive lysosomal-metabolic signaling and neurodevelopmental deficits that precede Purkinje cell loss in a mouse model of Niemann-Pick Type-C disease. Sci Rep. 2023 04 06; 13(1):5665.

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Oyagbemi AA, Ajibade TO, Esan OO, Adetona MO, Obisesan AD, Adeogun AV, Awoyomi OV, Badejo JA, Adedapo ADA, Omobowale TO, Olaleye OI, Ola-Davies OE, Saba AB, Adedapo AA, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Yakubu MA, Nwulia E, Oguntibeju OO. Naringin abrogates angiotensin-converting enzyme (ACE) activity and?podocin signalling pathway in cobalt chloride-induced nephrotoxicity and hypertension. Biomarkers. 2023 Mar; 28(2):206-216.

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Nakayama Y, Mukai N, Kreitzer G, Patwari P, Yoshioka J. Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart. Circ Res. 2022 09 02; 131(6):510-527.

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