DNA-Binding Proteins

"DNA-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Descriptor ID	D004268
MeSH Number(s)	D12.776.260
Concept/Terms	DNA-Binding Proteins DNA-Binding Proteins DNA Binding Proteins DNA Binding Protein Binding Protein, DNA Single-Stranded DNA Binding Proteins Single-Stranded DNA Binding Proteins Single Stranded DNA Binding Proteins SS DNA BP DNA Single-Stranded Binding Protein DNA Single Stranded Binding Protein Single-Stranded DNA-Binding Protein DNA-Binding Protein, Single-Stranded Single Stranded DNA Binding Protein DNA Helix Destabilizing Proteins DNA Helix Destabilizing Proteins

Below are MeSH descriptors whose meaning is more general than "DNA-Binding Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]

Below are MeSH descriptors whose meaning is related to "DNA-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "DNA-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Binding Proteins" by people in this website by year, and whether "DNA-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 433 publications over 30 distinct years, with a maximum of 30 publications in 2002 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	8	1	9
1997	8	3	11
1998	14	8	22
1999	8	4	12
2000	11	6	17
2001	13	5	18
2002	18	12	30
2003	12	7	19
2004	13	9	22
2005	14	16	30
2006	13	5	18
2007	8	13	21
2008	6	10	16
2009	10	8	18
2010	9	8	17
2011	8	5	13
2012	11	7	18
2013	6	5	11
2014	6	5	11
2015	10	3	13
2016	6	3	9
2017	6	2	8
2018	5	9	14
2019	8	10	18
2020	4	7	11
2021	4	1	5
2022	2	4	6
2023	3	3	6
2024	2	1	3
2025	6	1	7

Below are the most recent publications written about "DNA-Binding Proteins" by people in Profiles.

Holliday H, Khan A, Ehteda A, Nguyen H, Ross SE, Jayatilleke N, Gopalakrishnan A, Wang E, Sanguino YC, Kavanagh D, Guo X, Liu J, Lawrence D, Sun CX, Lehmann R, Ip CK, Lee A, Rangel-Sanchez L, Li W, Salomon R, Firestein R, Weatheritt RJ, Valdes-Mora F, Dinger ME, Phoenix TN, Mayoh C, Rayner BS, Tsoli M, Ziegler DS. Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma. Sci Transl Med. 2026 Jan 14; 18(832):eadr1557.

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Xie X, Thornton AM, Tanwar S, Korty P, Wells AC, Segrist E, Teijeiro A, Rivera CA, Wei D, Chen X, Zhu J, Khleborodova A, Hill T, Markowitz TE, Smelkinson M, Kabat J, Veres T, Schwartz OM, Otaizo-Carrasquero F, Gardina P, Shamsaddini A, Martens C, Cho K, Lin CC, Khillan JS, Levin Y, Wu Y, Shevach EM. Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development. Cell Rep. 2026 Jan 27; 45(1):116838.

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Short JE, Sharek L, Meckler JF, Stoytchev I, Tran CT, Errard C, Hew BE, Johnson BE, Waller DF, Xie S, Higgins JJ, Tabibiazar R, Owens JB. Gene-sized DNA insertion at genomic safe harbors in human cells using a site-directed transposase. Nucleic Acids Res. 2025 Nov 26; 53(22).

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Montes-Rodr?guez IM, Centeno-Girona H, P?rez-M?rtir SV, Rivera N, Cruz-Correa M. Actionable Genes and Carcinogenic Pathways for Gastric Cancer in Latinos. Cancer Med. 2025 Sep; 14(17):e71216.

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Holmlund H, Coul?e M, Yamauchi Y, Yarbabaeva B, Tekayev M, Garcia IR, Feudjio OU, de la Iglesia A, Larcombe L, Ellis PJI, Cocquet J, Ward MA. Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells. Cell Death Differ. 2026 Feb; 33(2):392-410.

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Chang S, Fu X, Xiang L, Yuan Y, Xiao S, Peng L, Xie X, Kang X, Feng X, Ashktorab H, Peng Y, Jin Z, Zhang X. A novel protein encoded by circTUBGCP3 blocks ferroptosis and promotes gastric cancer progression. J Biol Chem. 2025 09; 301(9):110507.

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Chouhan M, Kumar M, Dwivedi VD, Kashyap VK, Singh HN, Kumar S. Harnessing Natural Product Compounds to Target Dormancy Survival Regulator (DosR) in Latent Tuberculosis Infection (LTBI): An In Silico Strategy Against Dormancy. Adv Respir Med. 2025 Jun 16; 93(3).

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van Heesch T, Sharma S, van Erp B, Ort?z APA, Dame RT, Vreede J, Gavvala K. Adaptation of DNA to Protein Binding Revealed by Spectroscopy and Molecular Simulation. J Phys Chem B. 2025 Jun 12; 129(23):5653-5663.

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Gemeinhardt TM, Regy RM, Phan TM, Pal N, Sharma J, Senkovich O, Mendiola AJ, Ledterman HJ, Henrickson A, Lopes D, Kapoor U, Bihani A, Sihou D, Kim YC, Jeruzalmi D, Demeler B, Kim CA, Mittal J, Francis NJ. A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization. Mol Cell. 2025 Jun 05; 85(11):2128-2146.e15.

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Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R. Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair. Nat Commun. 2025 Apr 10; 16(1):3416.

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