Smad Proteins

"Smad Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.

Descriptor ID	D051785
MeSH Number(s)	D12.644.360.024.334 D12.776.157.057.170 D12.776.260.713 D12.776.476.024.428 D12.776.930.806
Concept/Terms	Smad Proteins Smad Proteins Mothers Against Decapentaplegic Homolog Sma- and Mad-Related Proteins

Below are MeSH descriptors whose meaning is more general than "Smad Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Smad Proteins [D12.644.360.024.334]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Smad Proteins [D12.776.157.057.170]
DNA-Binding Proteins [D12.776.260]
Smad Proteins [D12.776.260.713]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Smad Proteins [D12.776.476.024.428]
Transcription Factors [D12.776.930]
Smad Proteins [D12.776.930.806]

Below are MeSH descriptors whose meaning is related to "Smad Proteins".

Below are MeSH descriptors whose meaning is more specific than "Smad Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Smad Proteins" by people in this website by year, and whether "Smad Proteins" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2008	0	1	1
2009	1	0	1
2011	0	2	2
2013	1	0	1
2015	0	1	1
2020	0	1	1

Below are the most recent publications written about "Smad Proteins" by people in Profiles.

Jian J, Zhang P, Li Y, Liu B, Zhang Y, Zhang L, Shao XM, Zhuang J, Xiao D. Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 2020; 10(25):11820-11836.

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Yan H, Chen Y, Li L, Jiang J, Wu G, Zuo Y, Zhang JH, Feng H, Yan X, Liu F. Decorin alleviated chronic hydrocephalus via inhibiting TGF-?1/Smad/CTGF pathway after subarachnoid hemorrhage in rats. Brain Res. 2016 Jan 01; 1630:241-53.

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Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC. Inhibition of TGF-?1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol. 2013 Aug; 58:487-94.

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Braga M, Bhasin S, Jasuja R, Pervin S, Singh R. Testosterone inhibits transforming growth factor-? signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol. 2012 Mar 05; 350(1):39-52.

View in: PubMed
Halder SK, Goodwin JS, Al-Hendy A. 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab. 2011 Apr; 96(4):E754-62.

View in: PubMed
Graham TR, Odero-Marah VA, Chung LW, Agrawal KC, Davis R, Abdel-Mageed AB. PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells. Prostate. 2009 Feb 01; 69(2):168-80.

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Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol. 2008 Feb; 196(2):235-49.

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Villacorta L, Garcia-Barrio MT, Chen YE. Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors. Curr Atheroscler Rep. 2007 Sep; 9(3):230-7.

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Lee HG, Ueda M, Zhu X, Perry G, Smith MA. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? J Neurosci Res. 2006 Dec; 84(8):1856-61.

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