A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

Descriptor ID	D050791
MeSH Number(s)	D12.644.360.024.342 D12.776.157.057.186 D12.776.476.024.430 D12.776.930.840
Concept/Terms	STAT Transcription Factors STAT Transcription Factors Transcription Factors, STAT STAT (Signal Transducers and Activators of Transcription) Proteins

Below are MeSH descriptors whose meaning is more general than "STAT Transcription Factors".

Below are MeSH descriptors whose meaning is related to "STAT Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "STAT Transcription Factors".