GRB2 Adaptor Protein

"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).

Descriptor ID	D051380
MeSH Number(s)	D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377
Concept/Terms	GRB2 Adaptor Protein GRB2 Adaptor Protein Abundant Src Homology Protein Growth Factor Receptor-Bound Protein-2 Growth Factor Receptor Bound Protein 2 GRB2 Adaptor Protein, Grb3-3 Isoform GRB2 Adaptor Protein, Grb3-3 Isoform GRB2 Adaptor Protein, Grb3 3 Isoform Grb3-3 Adaptor Protein

Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
GRB2 Adaptor Protein [D12.644.360.024.290]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
GRB2 Adaptor Protein [D12.776.157.057.041]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
GRB2 Adaptor Protein [D12.776.476.024.377]

Below are MeSH descriptors whose meaning is related to "GRB2 Adaptor Protein".

Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 1995 and 2001 and 2002 and 2003 and 2006 and 2011 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	1	1
2006	0	1	1
2011	0	1	1
2015	1	0	1

Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96.

View in: PubMed
Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin ?1 recycling in cell migration. J Biol Chem. 2011 Dec 23; 286(51):43735-43747.

View in: PubMed
Zhou YW, Thomason DB, Gullberg D, Jarrett HW. Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling. Biochemistry. 2006 Feb 21; 45(7):2042-52.

View in: PubMed
Oak SA, Zhou YW, Jarrett HW. Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J Biol Chem. 2003 Oct 10; 278(41):39287-95.

View in: PubMed
Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE. Insulin receptor substrate 4 associates with the protein IRAS. J Biol Chem. 2002 May 31; 277(22):19439-47.

View in: PubMed
Oak SA, Russo K, Petrucci TC, Jarrett HW. Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling. Biochemistry. 2001 Sep 18; 40(37):11270-8.

View in: PubMed
Park RK, Kyono WT, Liu Y, Durden DL. CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling. J Immunol. 1998 May 15; 160(10):5018-27.

View in: PubMed
Erwin RA, Kirken RA, Malabarba MG, Farrar WL, Rui H. Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless. Endocrinology. 1995 Aug; 136(8):3512-8.

View in: PubMed

People

Explore

Similar Concepts

Top Journals