14-3-3 Proteins

"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Descriptor ID	D048948
MeSH Number(s)	D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
Concept/Terms	14-3-3 Proteins 14-3-3 Proteins 14 3 3 Proteins 14-3-3 Protein 14 3 3 Protein Brain 14-3-3 Protein 14-3-3 Protein, Brain Brain 14 3 3 Protein Protein 14-3-3 14-3-3 Protein, tau Isoform 14-3-3 Protein, tau Isoform 14 3 3 Protein, tau Isoform 14-3-3tau Protein 14 3 3tau Protein Protein, 14-3-3tau 14-3-3 tau Protein 14 3 3 tau Protein 14-3-3 Protein, zeta Isoform 14-3-3 Protein, zeta Isoform 14 3 3 Protein, zeta Isoform 14-3-3zeta Protein 14 3 3zeta Protein 14-3-3 zeta Protein 14 3 3 zeta Protein 14-3-3 Protein, eta Isoform 14-3-3 Protein, eta Isoform 14 3 3 Protein, eta Isoform 14-3-3eta Protein 14 3 3eta Protein 14-3-3 eta Protein 14 3 3 eta Protein eta Protein, 14-3-3 14-3-3 Protein, epsilon Isoform 14-3-3 Protein, epsilon Isoform 14 3 3 Protein, epsilon Isoform 14-3-3 epsilon Protein 14 3 3 epsilon Protein 14-3-3epsilon Protein 14 3 3epsilon Protein 14-3-3 Protein, gamma Isoform 14-3-3 Protein, gamma Isoform 14 3 3 Protein, gamma Isoform 14-3-3gamma Protein 14 3 3gamma Protein 14-3-3 gamma Protein 14 3 3 gamma Protein 14-3-3 Protein, beta Isoform 14-3-3 Protein, beta Isoform 14 3 3 Protein, beta Isoform 14-3-3beta Protein 14 3 3beta Protein 14-3-3 beta Protein 14 3 3 beta Protein

Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
14-3-3 Proteins [D12.776.157.057.002]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
14-3-3 Proteins [D12.776.476.024.050]

Below are MeSH descriptors whose meaning is related to "14-3-3 Proteins".

Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.

Bar chart showing 19 publications over 13 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	2	2
2003	0	3	3
2004	0	1	1
2006	0	1	1
2007	2	0	2
2009	1	1	2
2010	0	1	1
2012	2	0	2
2013	1	0	1
2017	1	0	1
2019	1	0	1
2023	0	1	1

Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.

Bashi A, Lekpor C, Hood JL, Thompson WE, Stiles JK, Driss A. Modulation of Heme-Induced Inflammation Using MicroRNA-Loaded Liposomes: Implications for Hemolytic Disorders Such as Malaria and Sickle Cell Disease. Int J Mol Sci. 2023 Nov 29; 24(23).

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Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 08 13; 28(7):1799-1813.e5.

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Ng YS, Sorvina A, Bader CA, Weiland F, Lopez AF, Hoffmann P, Shandala T, Brooks DA. Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3e in Metabolic Pathways. J Proteome Res. 2017 05 05; 16(5):1976-1987.

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Morales D, Hechavarria R, Wojna V, Acevedo SF. YWHAE/14-3-3e: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment. J Neurovirol. 2013 Oct; 19(5):471-8.

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Morales D, Skoulakis EC, Acevedo SF. 14-3-3s are potential biomarkers for HIV-related neurodegeneration. J Neurovirol. 2012 Oct; 18(5):341-53.

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Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3s regulates ?-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3?. PLoS One. 2012; 7(6):e40193.

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Du J, Chen L, Luo X, Shen Y, Dou Z, Shen J, Cheng L, Chen Y, Li C, Wang H, Yao X. 14-3-3zeta cooperates with phosphorylated Plk1 and is required for correct cytokinesis. Front Biosci (Schol Ed). 2012 01 01; 4(2):639-50.

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Yang X, Xuan Q, Mo L, Huang F, Pang Y, He M, Lin W, Li QQ, Mo Z. Differential expression of genes in co-cultured versus separately cultured fibroblasts and epithelial cells from human benign hyperplastic prostate tissues. Int J Mol Med. 2010 Jul; 26(1):17-25.

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Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr; 11(4):420-32.

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Barry EF, Felquer FA, Powell JA, Biggs L, Stomski FC, Urbani A, Ramshaw H, Hoffmann P, Wilce MC, Grimbaldeston MA, Lopez AF, Guthridge MA. 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. J Biol Chem. 2009 May 01; 284(18):12080-90.

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