A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Descriptor ID	D010300
MeSH Number(s)	C10.228.140.079.862.500 C10.228.662.600.400 C10.574.812
Concept/Terms	Parkinson Disease Parkinson Disease Idiopathic Parkinson's Disease Lewy Body Parkinson Disease Lewy Body Parkinson's Disease Primary Parkinsonism Parkinsonism, Primary Parkinson Disease, Idiopathic Parkinson's Disease Parkinson's Disease, Idiopathic Parkinson's Disease, Lewy Body Idiopathic Parkinson Disease Paralysis Agitans

Below are MeSH descriptors whose meaning is more general than "Parkinson Disease".

Below are MeSH descriptors whose meaning is related to "Parkinson Disease".

Below are MeSH descriptors whose meaning is more specific than "Parkinson Disease".