tau Proteins

"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

Descriptor ID	D016875
MeSH Number(s)	D12.776.220.600.450.510 D12.776.631.560.510
Concept/Terms	tau Proteins tau Proteins Proteins, tau tau Protein Protein, tau

Below are MeSH descriptors whose meaning is more general than "tau Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Microtubule Proteins [D12.776.220.600]
Microtubule-Associated Proteins [D12.776.220.600.450]
tau Proteins [D12.776.220.600.450.510]
Nerve Tissue Proteins [D12.776.631]
Microtubule-Associated Proteins [D12.776.631.560]
tau Proteins [D12.776.631.560.510]

Below are MeSH descriptors whose meaning is related to "tau Proteins".

Below are MeSH descriptors whose meaning is more specific than "tau Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.

Bar chart showing 161 publications over 30 distinct years, with a maximum of 11 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	1	1
1998	1	2	3
1999	0	1	1
2000	4	2	6
2001	0	1	1
2002	4	1	5
2003	3	2	5
2004	3	3	6
2005	4	3	7
2006	3	6	9
2007	2	3	5
2008	5	3	8
2009	4	2	6
2010	3	4	7
2011	2	2	4
2012	2	1	3
2013	4	1	5
2014	1	1	2
2015	2	4	6
2016	6	3	9
2017	5	0	5
2018	5	3	8
2019	3	2	5
2020	5	5	10
2021	4	3	7
2022	1	0	1
2023	3	5	8
2024	10	1	11
2025	3	3	6

Below are the most recent publications written about "tau Proteins" by people in Profiles.

Garc?a-Carlos CA, Basurto-Islas G, Perry G, Campos-Ram?rez C, Mondrag?n-Rodr?guez S. Hyperphosphorylated Tau Induces Cortical Hypoexcitability in Transgenic Mouse Models: A Meta-Analysis. J Integr Neurosci. 2025 Aug 28; 24(8):39192.

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Avila J, Hern?ndez F, Perry G. Amyloid and tau pathologies cross-talk to promote Alzheimers disease: novel mechanistic insights. Neuroscience. 2025 Aug 30; 582:58-62.

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Bogadi S, Bhaskaran M, Ravichandran V, Nesamony J, Chelliah S, Kuppusamy G, Prakash GM, Karri VVSR, Mallick S, Farahim F, Ali T, Babu DR, Subramaniyan V. Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer's Disease. Mol Neurobiol. 2025 Aug; 62(8):10915-10934.

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Stephens MC, Li J, Mair M, Moore J, Zhu K, Tarkunde A, Amoh B, Perez AM, Bhakare A, Guo F, Shulman JM, Al-Ramahi I, Botas J. Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease. Am J Hum Genet. 2025 May 01; 112(5):1081-1096.

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Liang J, Hussainy S, Lee SM, Wu G, Bautista N, Ding M, Wang H, LaFleur B, Perry G, Wang X. Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition. Neurology. 2025 Feb 25; 104(4):e210250.

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Khan KA, Esa M, Kamal Z, Ullah B, Perry G, Kamal S, Ahmad S, Hussain H, Ullah A, Shafique M. Conventional and Emerging Drug Targeting Sites in Alzheimer's Disease and the Role of Translational Informatics in its Diagnosis and Management. Curr Neuropharmacol. 2025; 23(14):1894-1917.

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Xiyang Y, Gao J, Ding M, Ren X, Appleby BS, Leverenz JB, Miyagi M, Pillai JA, Perry G, Wang X. Exacerbated mitochondrial dynamic abnormalities without evident tau pathology in rapidly progressive Alzheimer's disease. J Alzheimers Dis. 2024 Dec; 102(4):1074-1083.

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Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Plascencia-Villa G, Zhu X, Perry G, Dettmer U, Fortin JS. Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against a-synuclein and 2N4R tau. Bioorg Med Chem. 2024 Dec 15; 116:117990.

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Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. ACS Chem Neurosci. 2024 11 06; 15(21):3915-3931.

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Lowe VJ, Mester CT, Lundt ES, Lee J, Ghatamaneni S, Algeciras-Schimnich A, Campbell MR, Graff-Radford J, Nguyen A, Min HK, Senjem ML, Machulda MM, Schwarz CG, Dickson DW, Murray ME, Kandimalla KK, Kantarci K, Boeve B, Vemuri P, Jones DT, Knopman D, Jack CR, Petersen RC, Mielke MM. Amyloid PET detects the deposition of brain A? earlier than CSF fluid biomarkers. Alzheimers Dement. 2024 Nov; 20(11):8097-8112.

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