Dynamins

"Dynamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.

Descriptor ID	D034281
MeSH Number(s)	D08.811.277.040.330.200 D12.776.220.600.450.200 D12.776.543.990.400
Concept/Terms	Dynamins Dynamins Dynamin Dephosphin GTPase-Deficient Dynamin GTPase-Deficient Dynamin Dynamin, GTPase-Deficient GTPase Deficient Dynamin Dynamin, Alanine44 Substituted With Lysine Dynamin, Mutated Form, K44A Dynamin K44A

Below are MeSH descriptors whose meaning is more general than "Dynamins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
Dynamins [D08.811.277.040.330.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Microtubule Proteins [D12.776.220.600]
Microtubule-Associated Proteins [D12.776.220.600.450]
Dynamins [D12.776.220.600.450.200]
Membrane Proteins [D12.776.543]
Vesicular Transport Proteins [D12.776.543.990]
Dynamins [D12.776.543.990.400]

Below are MeSH descriptors whose meaning is more specific than "Dynamins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dynamins" by people in this website by year, and whether "Dynamins" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2004	0	1	1
2007	0	1	1
2009	0	1	1
2010	1	2	3
2011	0	1	1
2012	0	1	1
2015	1	0	1
2017	1	1	2
2020	1	0	1

Below are the most recent publications written about "Dynamins" by people in Profiles.

Flippo KH, Lin Z, Dickey AS, Zhou X, Dhanesha NA, Walters GC, Liu Y, Merrill RA, Meller R, Simon RP, Chauhan AK, Usachev YM, Strack S. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci. 2020 04 08; 40(15):3119-3129.

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Mart?n-Maestro P, Gargini R, Garc?a E, Perry G, Avila J, Garc?a-Escudero V. Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. Oxid Med Cell Longev. 2017; 2017:9302761.

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Wu P, Li Y, Zhu S, Wang C, Dai J, Zhang G, Zheng B, Xu S, Wang L, Zhang T, Zhou P, Zhang JH, Shi H. Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress. Neurochem Res. 2017 May; 42(5):1449-1458.

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Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP. Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochim Biophys Acta. 2015 Jun; 1850(6):1310-8.

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Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet. 2012 May 01; 21(9):1931-44.

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Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 2011 Oct; 10(5):807-23.

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Barylko B, Wang L, Binns DD, Ross JA, Tassin TC, Collins KA, Jameson DM, Albanesi JP. The proline/arginine-rich domain is a major determinant of dynamin self-activation. Biochemistry. 2010 Dec 21; 49(50):10592-4.

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Marie B, Pym E, Bergquist S, Davis GW. Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog. J Neurosci. 2010 Jun 16; 30(24):8071-82.

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Bonda DJ, Wang X, Perry G, Smith MA, Zhu X. Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging. 2010 Mar 01; 27(3):181-92.

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Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009 Jul 15; 29(28):9090-103.

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