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Roger simon

Title
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentClinical Medicine
Address720 Westview Drive, SW
MRC
Atlanta GA 30310
Phone4047528811
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    R01HL033198     (SIMON, ROGER P)Mar 1, 1985 - Feb 29, 1988
    NIH
    ROLE OF THE CNS IN PULMONARY FLUID AND PROTEIN FLUX
    Role: Principal Investigator
    R01NS024728     (SIMON, ROGER PANCOAST)Jul 1, 1988 - Dec 31, 2010
    NIH
    Cell excitation in ischemic brain injury.
    Role: Principal Investigator
    P01NS035965     (SIMON, ROGER PANCOAST)Jul 15, 1997 - Apr 30, 2009
    NIH
    Molecular Mechanisms of Ischemia
    Role: Principal Investigator
    R01NS039016     (SIMON, ROGER PANCOAST)Jul 1, 1999 - Jun 30, 2010
    NIH
    Molecular mechanisms of seizure induced brain injury
    Role: Principal Investigator
    R01NS041935     (SIMON, ROGER PANCOAST)Aug 1, 2001 - Jul 31, 2005
    NIH
    Caspases mediate seizure-induced brain injury
    Role: Principal Investigator
    R21NS042799     (SIMON, ROGER P)Jan 1, 2002 - Dec 31, 2003
    NIH
    A role of acid-sensing ion channels in ischemia
    Role: Principal Investigator
    U13NS043334     (SIMON, ROGER PANCOAST)Mar 5, 2002 - Feb 28, 2007
    NIH
    23rd Princeton Conference on Cerebrovascular Disease
    Role: Principal Investigator
    R21NS046290     (SIMON, ROGER PANCOAST)Jun 1, 2004 - Dec 31, 2006
    NIH
    14-3-3 protein and gene profiling in epileptic brain
    Role: Principal Investigator
    R01NS050610     (SIMON, ROGER PANCOAST)May 24, 2005 - Apr 30, 2010
    NIH
    Acid-sensing ion channels and ischemic brain injury
    Role: Principal Investigator
    R01NS047622     (SIMON, ROGER PANCOAST)Jul 1, 2005 - Mar 30, 2010
    NIH
    Molecular determinants of epileptic brain injury
    Role: Principal Investigator
    R41NS064845     (SIMON, ROGER PANCOAST)Aug 1, 2009 - Jul 31, 2011
    NIH
    A Novel Approach to Stroke Treatment: Acid-Sensing Iion Channel Inhibitors
    Role: Principal Investigator
    R56NS073714     (SIMON, ROGER PANCOAST)Sep 30, 2011 - Aug 31, 2013
    NIH
    MicroRNAs as Molecular Effectors of Seizure-preconditioning
    Role: Principal Investigator
    R01NS104349     (SIMON, ROGER PANCOAST)Dec 15, 2017 - Mar 31, 2024
    NIH
    Mechanisms of ASIC-mediated neuronal injury
    Role: Principal Investigator
    R21NS116726     (MELLER, ROBERT)May 1, 2020 - Oct 31, 2021
    NIH
    Blood transcriptome profiling following seizures
    Role: Co-Principal Investigator
    R01NS112422     (MELLER, ROBERT)Jul 15, 2020 - Apr 30, 2025
    NIH
    Blood transcriptomics as CT adjuvant to exclude hemorrhage in acute stroke
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sun H, Yang T, Simon R, Xiong ZG, Leng T. Cholestane-3?,5a,6?-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury. Stroke. 2024 Jun; 55(6):1660-1671. PMID: 38660789.
      Citations:    Fields:    Translation:AnimalsCells
    2. Sun HW, Chu XP, Simon RP, Xiong ZG, Leng TD. Inhibition of Acid-Sensing Ion Channels by KB-R7943, a Reverse Na+/Ca2+ Exchanger Inhibitor. Biomolecules. 2023 03 10; 13(3). PMID: 36979442.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Xie M, Leng T, Maysami S, Pearson A, Simon R, Xiong ZG, Meller R. Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules. 2022 09 01; 12(9). PMID: 36139053.
      Citations:    Fields:    Translation:Animals
    4. Zha XM, Xiong ZG, Simon RP. pH and proton-sensitive receptors in brain ischemia. J Cereb Blood Flow Metab. 2022 08; 42(8):1349-1363. PMID: 35301897.
      Citations: 7     Fields:    Translation:AnimalsCells
    5. Gee BE, Pearson A, Buchanan-Perry I, Simon RP, Archer DR, Meller R. Whole Blood Transcriptome Analysis in Children with Sickle Cell Anemia. Front Genet. 2021; 12:737741. PMID: 35095995.
      Citations:    
    6. Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, Ji Y, Simon RP, Xiong ZG, Zha XM. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia. Stroke. 2020 12; 51(12):3690-3700. PMID: 33059544.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Flippo KH, Lin Z, Dickey AS, Zhou X, Dhanesha NA, Walters GC, Liu Y, Merrill RA, Meller R, Simon RP, Chauhan AK, Usachev YM, Strack S. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci. 2020 04 08; 40(15):3119-3129. PMID: 32144179.
      Citations: 22     Fields:    Translation:AnimalsCells
    8. Chang SY, DeVera C, Yang Z, Yang T, Song L, McDowell A, Xiong ZG, Simon R, Zhou A. Hippocampal changes in mice lacking an active prohormone convertase 2. Hippocampus. 2020 07; 30(7):715-723. PMID: 32057164.
      Citations: 1     Fields:    Translation:Animals
    9. Cao L, Cobbs A, Simon RP, Zhou A. Distinct plasma proteomic changes in male and female African American stroke patients. Int J Physiol Pathophysiol Pharmacol. 2019; 11(2):12-20. PMID: 31149323.
      Citations:    
    10. Simon R, Meller R, Yang T, Pearson A, Wilson G. Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion. Transl Stroke Res. 2019 12; 10(6):664-671. PMID: 30535792.
      Citations: 13     Fields:    Translation:AnimalsCells
    11. Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, B?tker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME. Enhancing and Extending Biological Performance and Resilience. Dose Response. 2018 Jul-Sep; 16(3):1559325818784501. PMID: 30140178.
      Citations:    
    12. Hernandez-Encarnacion L, Sharma P, Simon R, Zhou A. Condition-specific transcriptional regulation of neuronal ion channel genes in brain ischemia. Int J Physiol Pathophysiol Pharmacol. 2017; 9(6):192-201. PMID: 29348796.
      Citations:    
    13. Hardy JJ, Mooney SR, Pearson AN, McGuire D, Correa DJ, Simon RP, Meller R. Assessing the accuracy of blood RNA profiles to identify patients with post-concussion syndrome: A pilot study in a military patient population. PLoS One. 2017; 12(9):e0183113. PMID: 28863142.
      Citations: 5     Fields:    Translation:HumansCells
    14. Brager AJ, Yang T, Ehlen JC, Simon RP, Meller R, Paul KN. Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection. Sleep. 2016 Nov 01; 39(11):2033-2040. PMID: 27568798.
      Citations: 4     Fields:    Translation:Animals
    15. Jiang N, Wu J, Leng T, Yang T, Zhou Y, Jiang Q, Wang B, Hu Y, Ji YH, Simon RP, Chu XP, Xiong ZG, Zha XM. Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury. J Cereb Blood Flow Metab. 2017 Feb; 37(2):528-540. PMID: 26861816.
      Citations: 27     Fields:    Translation:AnimalsCells
    16. Li MH, Leng TD, Feng XC, Yang T, Simon RP, Xiong ZG. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016 08 26; 291(35):18370-83. PMID: 27402850.
      Citations: 17     Fields:    Translation:Animals
    17. Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016 06; 22(6):468-76. PMID: 26890278.
      Citations: 20     Fields:    Translation:AnimalsCells
    18. Meller R, Pearson AN, Hardy JJ, Hall CL, McGuire D, Frankel MR, Simon RP. Blood transcriptome changes after stroke in an African American population. Ann Clin Transl Neurol. 2016 02; 3(2):70-81. PMID: 26900583.
      Citations: 12     Fields:    
    19. Simon RP. Epigenetic modulation of gene expression governs the brain's response to injury. Neurosci Lett. 2016 06 20; 625:16-9. PMID: 26739198.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    20. Meller R, Pearson A, Simon RP. Dynamic changes in DNA methylation in ischemic tolerance. Front Neurol. 2015; 6:102. PMID: 26029158.
      Citations:    
    21. Meller R, Simon RP. A critical review of mechanisms regulating remote preconditioning-induced brain protection. J Appl Physiol (1985). 2015 Nov 15; 119(10):1135-42. PMID: 25953834.
      Citations: 18     Fields:    Translation:HumansAnimals
    22. Reynolds JP, Miller-Delaney SF, Jimenez-Mateos EM, Sano T, McKiernan RC, Simon RP, Henshall DC. Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning. Front Neurol. 2015; 6:46. PMID: 25806020.
      Citations:    
    23. Simon R. Post-conditioning and reperfusion injury in the treatment of stroke. Dose Response. 2014 Dec; 12(4):590-9. PMID: 25552959.
      Citations:    
    24. Li MH, Liu SQ, Inoue K, Lan J, Simon RP, Xiong ZG. Acid-sensing ion channels in mouse olfactory bulb M/T neurons. J Gen Physiol. 2014 Jun; 143(6):719-31. PMID: 24821964.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Bian F, Simon RP, Li Y, David L, Wainwright J, Hall CL, Frankel M, Zhou A. Nascent proteomes in peripheral blood mononuclear cells as a novel source for biomarker discovery in human stroke. Stroke. 2014 Apr; 45(4):1177-9. PMID: 24558093.
      Citations: 6     Fields:    Translation:HumansCells
    26. Garrett SL, Sawyer P, Kennedy RE, McGuire D, Simon RP, Strothers HS, Allman RM. Racial and sex differences in associations between activities of daily living and cognition in community-dwelling older adults. J Am Geriatr Soc. 2013 Dec; 61(12):2174-2180. PMID: 24479147.
      Citations: 7     Fields:    Translation:Humans
    27. Simon R. Neuroglobin: neuroprotection and neurogenesis. Neurosci Lett. 2013 Aug 09; 549:1-2. PMID: 23727429.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    28. Mandava P, Murthy SB, Munoz M, McGuire D, Simon RP, Alexandrov AV, Albright KC, Boehme AK, Martin-Schild S, Martini S, Kent TA. Explicit consideration of baseline factors to assess recombinant tissue-type plasminogen activator response with respect to race and sex. Stroke. 2013 Jun; 44(6):1525-31. PMID: 23674524.
      Citations: 7     Fields:    Translation:Humans
    29. Meller R, Simon RP. Tolerance to ischemia - an increasingly complex biology. Transl Stroke Res. 2013 Feb; 4(1):40-50. PMID: 23504451.
      Citations: 14     Fields:    Translation:HumansAnimals
    30. McKiernan RC, Jimenez-Mateos EM, Sano T, Bray I, Stallings RL, Simon RP, Henshall DC. Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Exp Neurol. 2012 Oct; 237(2):346-54. PMID: 22771761.
      Citations: 50     Fields:    Translation:AnimalsCells
    31. McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O'Brien D, Meller R, Simon RP, Stallings RL, Henshall DC. Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One. 2012; 7(5):e35921. PMID: 22615744.
      Citations: 62     Fields:    Translation:HumansAnimals
    32. Meller CL, Meller R, Simon RP, Culpepper KM, Podrabsky JE. Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus. J Comp Physiol B. 2012 Oct; 182(7):909-20. PMID: 22570106.
      Citations: 11     Fields:    Translation:Animals
    33. Leung PY, Stevens SL, Packard AE, Lessov NS, Yang T, Conrad VK, van den Dungen NN, Simon RP, Stenzel-Poore MP. Toll-like receptor 7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism. Stroke. 2012 May; 43(5):1383-9. PMID: 22403050.
      Citations: 40     Fields:    Translation:AnimalsCells
    34. Simon RP, Meller R, Zhou A, Henshall D. Can genes modify stroke outcome and by what mechanisms? Stroke. 2012 Jan; 43(1):286-91. PMID: 22156698.
      Citations: 10     Fields:    Translation:Humans
    35. Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL, Henshall DC. miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. Am J Pathol. 2011 Nov; 179(5):2519-32. PMID: 21945804.
      Citations: 119     Fields:    Translation:AnimalsCells
    36. Thompson SJ, Ashley MD, St?hr S, Schindler C, Li M, McCarthy-Culpepper KA, Pearson AN, Xiong ZG, Simon RP, Henshall DC, Meller R. Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance. Int J Physiol Pathophysiol Pharmacol. 2011; 3(2):120-32. PMID: 21760970.
      Citations:    
    37. Stevens SL, Leung PY, Vartanian KB, Gopalan B, Yang T, Simon RP, Stenzel-Poore MP. Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury. J Neurosci. 2011 Jun 08; 31(23):8456-63. PMID: 21653850.
      Citations: 80     Fields:    Translation:AnimalsCells
    38. Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 03; 286(22):19331-9. PMID: 21478148.
      Citations: 24     Fields:    Translation:AnimalsCells
    39. Lin J, Chu X, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong Z. Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 2011 Apr; 112(4):977-81. PMID: 21385979.
      Citations: 12     Fields:    Translation:AnimalsCells
    40. Zhou A, Simon RP, David L. Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells. Int J Comput Biol Drug Des. 2011; 4(1):40-55. PMID: 21330693.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011 Feb 09; 31(6):2101-12. PMID: 21307247.
      Citations: 78     Fields:    Translation:AnimalsCells
    42. Coombes E, Jiang J, Chu XP, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. Antioxid Redox Signal. 2011 May 15; 14(10):1815-27. PMID: 20812867.
      Citations: 25     Fields:    Translation:AnimalsCells
    43. Engel T, Schindler CK, Sanz-Rodriguez A, Conroy RM, Meller R, Simon RP, Henshall DC. Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis. Int J Physiol Pathophysiol Pharmacol. 2011; 3(1):38-47. PMID: 21479101.
      Citations:    
    44. Li M, Kratzer E, Inoue K, Simon RP, Xiong ZG. Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons. J Physiol. 2010 Oct 15; 588(Pt 20):3883-900. PMID: 20724366.
      Citations: 20     Fields:    Translation:AnimalsCells
    45. Li M, Inoue K, Branigan D, Kratzer E, Hansen JC, Chen JW, Simon RP, Xiong ZG. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1247-60. PMID: 20216553.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    46. Stapels M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad J, Simon RP, Geromanos S, Langridge J, Lan JQ, Zhou A. Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance. Sci Signal. 2010 Mar 02; 3(111):ra15. PMID: 20197544.
      Citations: 58     Fields:    Translation:AnimalsCells
    47. Chai S, Li M, Branigan D, Xiong ZG, Simon RP. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010 Apr 23; 285(17):13002-11. PMID: 20185828.
      Citations: 35     Fields:    Translation:AnimalsCells
    48. Ordonez AN, Jessick VJ, Clayton CE, Ashley MD, Thompson SJ, Simon RP, Meller R. Rapid ischemic tolerance induced by adenosine preconditioning results in Bcl-2 interacting mediator of cell death (Bim) degradation by the proteasome. Int J Physiol Pathophysiol Pharmacol. 2010; 2(1):36-44. PMID: 20957068.
      Citations:    
    49. Lusardi TA, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan J, Simon RP, Saugstad JA. Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex. J Cereb Blood Flow Metab. 2010 Apr; 30(4):744-56. PMID: 20010955.
      Citations: 86     Fields:    Translation:Animals
    50. Johnson MB, Simon RP. Endogenous neuroprotective mechanisms in the brain. Epilepsia. 2009 Dec; 50 Suppl 12:3-4. PMID: 19941507.
      Citations: 2     Fields:    Translation:HumansAnimals
    51. Frei P, Huber LC, Simon RW, Bonani M, L?scher TF. Insufficient medication documentation at hospital admission of cardiac patients: a challenge for medication reconciliation. J Cardiovasc Pharmacol. 2009 Dec; 54(6):497-501. PMID: 19738488.
      Citations: 2     Fields:    Translation:Humans
    52. Loftus LT, Gala R, Yang T, Jessick VJ, Ashley MD, Ordonez AN, Thompson SJ, Simon RP, Meller R. Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance. Brain Res. 2009 May 26; 1272:71-80. PMID: 19332039.
      Citations: 26     Fields:    Translation:AnimalsCells
    53. Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009 Apr; 29(4):698-706. PMID: 19142196.
      Citations: 4     Fields:    Translation:AnimalsCells
    54. Sato Y, Meller R, Yang T, Taki W, Simon RP. Stereo-selective neuroprotection against stroke with vitamin A derivatives. Brain Res. 2008 Nov 19; 1241:188-92. PMID: 18824156.
      Citations: 7     Fields:    Translation:Animals
    55. Jimenez-Mateos EM, Hatazaki S, Johnson MB, Bellver-Estelles C, Mouri G, Bonner C, Prehn JH, Meller R, Simon RP, Henshall DC. Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiol Dis. 2008 Dec; 32(3):442-53. PMID: 18804535.
      Citations: 40     Fields:    Translation:AnimalsCells
    56. Doyle KP, Yang T, Lessov NS, Ciesielski TM, Stevens SL, Simon RP, King JS, Stenzel-Poore MP. Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab. 2008 Jun; 28(6):1235-48. PMID: 18364727.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    57. Maysami S, Lan JQ, Minami M, Simon RP. Proliferating progenitor cells: a required cellular element for induction of ischemic tolerance in the brain. J Cereb Blood Flow Metab. 2008 Jun; 28(6):1104-13. PMID: 18319730.
      Citations: 28     Fields:    Translation:AnimalsCells
    58. Li T, Ren G, Lusardi T, Wilz A, Lan JQ, Iwasato T, Itohara S, Simon RP, Boison D. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest. 2008 Feb; 118(2):571-82. PMID: 18172552.
      Citations: 143     Fields:    Translation:AnimalsCells
    59. Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage. Neuropharmacology. 2008 Sep; 55(3):310-8. PMID: 18308346.
      Citations: 331     Fields:    Translation:HumansAnimals
    60. Stevens SL, Ciesielski TM, Marsh BJ, Yang T, Homen DS, Boule JL, Lessov NS, Simon RP, Stenzel-Poore MP. Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab. 2008 May; 28(5):1040-7. PMID: 18183029.
      Citations: 97     Fields:    Translation:AnimalsCells
    61. Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Jessick V, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP. Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance. J Neurosci. 2008 Jan 02; 28(1):50-9. PMID: 18171922.
      Citations: 49     Fields:    Translation:AnimalsCells
    62. Xiong ZG, Pignataro G, Li M, Chang SY, Simon RP. Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr Opin Pharmacol. 2008 Feb; 8(1):25-32. PMID: 17945532.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    63. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Gala R, Simon RP. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008 Feb; 28(2):232-41. PMID: 17882162.
      Citations: 95     Fields:    Translation:Animals
    64. Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D. Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol. 2007 Oct; 171(4):1258-68. PMID: 17702891.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    65. Ren G, Li T, Lan JQ, Wilz A, Simon RP, Boison D. Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol. 2007 Nov; 208(1):26-37. PMID: 17716659.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    66. Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, Simon RP. A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem. 2007 Aug 03; 282(31):22668-77. PMID: 17548344.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    67. Bottlang M, Sommers MB, Lusardi TA, Miesch JJ, Simon RP, Xiong ZG. Modeling neural injury in organotypic cultures by application of inertia-driven shear strain. J Neurotrauma. 2007 Jun; 24(6):1068-77. PMID: 17600521.
      Citations: 5     Fields:    Translation:Animals
    68. Li T, Steinbeck JA, Lusardi T, Koch P, Lan JQ, Wilz A, Segschneider M, Simon RP, Br?stle O, Boison D. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain. 2007 May; 130(Pt 5):1276-88. PMID: 17472985.
      Citations: 77     Fields:    Translation:AnimalsCells
    69. Pignataro G, Maysami S, Studer FE, Wilz A, Simon RP, Boison D. Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. J Cereb Blood Flow Metab. 2008 Jan; 28(1):17-23. PMID: 17457365.
      Citations: 47     Fields:    Translation:AnimalsCells
    70. Rosenzweig HL, Minami M, Lessov NS, Coste SC, Stevens SL, Henshall DC, Meller R, Simon RP, Stenzel-Poore MP. Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1663-74. PMID: 17327883.
      Citations: 84     Fields:    Translation:AnimalsCells
    71. Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG. Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke. 2007 Feb; 38(2 Suppl):670-3. PMID: 17261712.
      Citations: 11     Fields:    Translation:HumansCells
    72. Stenzel-Poore MP, Stevens SL, King JS, Simon RP. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke. 2007 Feb; 38(2 Suppl):680-5. PMID: 17261715.
      Citations: 100     Fields:    Translation:HumansAnimals
    73. Xiong ZG, Chu XP, Simon RP. Acid sensing ion channels--novel therapeutic targets for ischemic brain injury. Front Biosci. 2007 Jan 01; 12:1376-86. PMID: 17127388.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    74. Simon R, Henshall D, Stoehr S, Meller R. Endogenous mechanisms of neuroprotection. Epilepsia. 2007; 48 Suppl 8:72-3. PMID: 18330006.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    75. Pignataro G, Studer FE, Wilz A, Simon RP, Boison D. Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants. J Cereb Blood Flow Metab. 2007 May; 27(5):919-27. PMID: 17119544.
      Citations: 24     Fields:    Translation:AnimalsCells
    76. Pignataro G, Simon RP, Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain. 2007 Jan; 130(Pt 1):151-8. PMID: 17114797.
      Citations: 131     Fields:    Translation:Animals
    77. Simon RP. Acidotoxicity trumps excitotoxicity in ischemic brain. Arch Neurol. 2006 Oct; 63(10):1368-71. PMID: 17030650.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    78. Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC. Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. Exp Neurol. 2006 Dec; 202(2):410-20. PMID: 16919273.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    79. Wang WZ, Chu XP, Li MH, Seeds J, Simon RP, Xiong ZG. Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J Biol Chem. 2006 Sep 29; 281(39):29369-78. PMID: 16882660.
      Citations: 31     Fields:    Translation:AnimalsCells
    80. Pignataro G, Simon RP, Boison D. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab. 2007 Jan; 27(1):1-5. PMID: 16685255.
      Citations: 52     Fields:    Translation:AnimalsCells
    81. Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC. Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. J Cereb Blood Flow Metab. 2006 Apr; 26(4):583-9. PMID: 16121124.
      Citations: 16     Fields:    Translation:HumansCells
    82. Li W, Luo Y, Zhang F, Signore AP, Gobbel GT, Simon RP, Chen J. Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway. J Cereb Blood Flow Metab. 2006 Feb; 26(2):181-98. PMID: 16001017.
      Citations: 30     Fields:    Translation:AnimalsCells
    83. Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP. Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem. 2006 Mar 17; 281(11):7429-36. PMID: 16431916.
      Citations: 47     Fields:    Translation:AnimalsCells
    84. Henshall DC, Simon RP. Epilepsy and apoptosis pathways. J Cereb Blood Flow Metab. 2005 Dec; 25(12):1557-72. PMID: 15889042.
      Citations: 79     Fields:    Translation:HumansAnimals
    85. Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP. CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab. 2005 Feb; 25(2):234-46. PMID: 15647742.
      Citations: 97     Fields:    Translation:AnimalsCells
    86. Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, Doyle K, Lessov NS, Simon RP, Stenzel-Poore MP. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab. 2005 Feb; 25(2):217-25. PMID: 15678124.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    87. Jin K, Minami M, Xie L, Sun Y, Mao XO, Wang Y, Simon RP, Greenberg DA. Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain. Aging Cell. 2004 Dec; 3(6):373-7. PMID: 15569354.
      Citations: 49     Fields:    Translation:AnimalsCells
    88. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci. 2004 Oct 06; 24(40):8678-89. PMID: 15470133.
      Citations: 83     Fields:    Translation:AnimalsCells
    89. Stenzel-Poore MP, Stevens SL, Simon RP. Genomics of preconditioning. Stroke. 2004 Nov; 35(11 Suppl 1):2683-6. PMID: 15459430.
      Citations: 45     Fields:    Translation:Animals
    90. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004 Sep 17; 118(6):687-98. PMID: 15369669.
      Citations: 488     Fields:    Translation:AnimalsCells
    91. Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP, Stenzel-Poore MP. Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke. 2004 Nov; 35(11):2576-81. PMID: 15375302.
      Citations: 99     Fields:    Translation:AnimalsCells
    92. Cao G, Xiao M, Sun F, Xiao X, Pei W, Li J, Graham SH, Simon RP, Chen J. Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death. J Neurosci. 2004 Jul 07; 24(27):6189-201. PMID: 15240811.
      Citations: 30     Fields:    Translation:AnimalsCells
    93. Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP. Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication. J Cereb Blood Flow Metab. 2004 Jun; 24(6):612-22. PMID: 15181368.
      Citations: 14     Fields:    Translation:AnimalsCells
    94. Henshall DC, Schindler CK, So NK, Lan JQ, Meller R, Simon RP. Death-associated protein kinase expression in human temporal lobe epilepsy. Ann Neurol. 2004 Apr; 55(4):485-94. PMID: 15048887.
      Citations: 16     Fields:    Translation:HumansCells
    95. Shinoda S, Araki T, Lan JQ, Schindler CK, Simon RP, Taki W, Henshall DC. Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. J Neurosci Res. 2004 Apr 01; 76(1):121-8. PMID: 15048936.
      Citations: 21     Fields:    Translation:AnimalsCells
    96. Shinoda S, Schindler CK, Meller R, So NK, Araki T, Yamamoto A, Lan JQ, Taki W, Simon RP, Henshall DC. Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest. 2004 Apr; 113(7):1059-68. PMID: 15057313.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    97. Schindler CK, Shinoda S, Simon RP, Henshall DC. Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Neurosci Lett. 2004 Feb 19; 356(3):163-6. PMID: 15036620.
      Citations: 15     Fields:    Translation:AnimalsCells
    98. Araki T, Shinoda S, Schindler CK, Quan-Lan J, Meller R, Taki W, Simon RP, Henshall DC. Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures. Hippocampus. 2004; 14(3):326-36. PMID: 15132432.
      Citations: 13     Fields:    Translation:AnimalsCells
    99. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet. 2003 Sep 27; 362(9389):1028-37. PMID: 14522533.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    100. Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem. 2003 Sep; 86(5):1260-70. PMID: 12911633.
      Citations: 23     Fields:    Translation:AnimalsCells
    101. Shinoda S, Schindler CK, Quan-Lan J, Saugstad JA, Taki W, Simon RP, Henshall DC. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. J Neurochem. 2003 Jul; 86(2):460-9. PMID: 12871587.
      Citations: 6     Fields:    Translation:AnimalsCells
    102. Chu XP, Zhu XM, Wei WL, Li GH, Simon RP, MacDonald JF, Xiong ZG. Acidosis decreases low Ca(2+)-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons. J Physiol. 2003 Jul 15; 550(Pt 2):385-99. PMID: 12777448.
      Citations: 16     Fields:    Translation:AnimalsCells
    103. Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci. 2003 May; 17(10):2065-76. PMID: 12786973.
      Citations:    
    104. Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 2003 May; 26(5):248-54. PMID: 12744841.
      Citations: 283     Fields:    Translation:HumansAnimals
    105. Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem. 2003 May; 85(3):670-9. PMID: 12694393.
      Citations: 3     Fields:    Translation:AnimalsCells
    106. Doyle KP, Simon RP, Snyder A, Stenzel-Poore MP. Working with GFP in the brain. Biotechniques. 2003 Mar; 34(3):492-4. PMID: 12669698.
      Citations: 2     Fields:    
    107. Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP. Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia. J Cereb Blood Flow Metab. 2003 Jan; 23(1):88-98. PMID: 12500094.
      Citations: 8     Fields:    Translation:AnimalsCells
    108. Henshall DC, Araki T, Schindler CK, Lan JQ, Tiekoter KL, Taki W, Simon RP. Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci. 2002 Oct 01; 22(19):8458-65. PMID: 12351720.
      Citations: 72     Fields:    Translation:AnimalsCells
    109. Araki T, Simon RP, Taki W, Lan JQ, Henshall DC. Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse. J Neurosci Res. 2002 Sep 01; 69(5):614-21. PMID: 12210827.
      Citations: 34     Fields:    Translation:AnimalsCells
    110. Henshall DC, Skradski SL, Meller R, Araki T, Minami M, Schindler CK, Lan JQ, Bonislawski DP, Simon RP. Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Neurobiol Dis. 2002 Jul; 10(2):71-87. PMID: 12127146.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    111. Meller R, Skradski SL, Simon RP, Henshall DC. Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Neurosci Lett. 2002 May 10; 324(1):33-6. PMID: 11983288.
      Citations: 6     Fields:    Translation:AnimalsCells
    112. Chu XP, Miesch J, Johnson M, Root L, Zhu XM, Chen D, Simon RP, Xiong ZG. Proton-gated channels in PC12 cells. J Neurophysiol. 2002 May; 87(5):2555-61. PMID: 11976391.
      Citations: 27     Fields:    Translation:AnimalsCells
    113. Jin K, Nagayama T, Mao X, Kawaguchi K, Hickey RW, Greenberg DA, Simon RP, Graham SH. Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. J Neurochem. 2002 Apr; 81(1):25-35. PMID: 12067235.
      Citations: 5     Fields:    Translation:AnimalsCells
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