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Richard Allsopp, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry and Physiology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921412
Fax8086921962
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    Collapse Overview 
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    Research projects:

    Analysis of the role of telomerase in stem cells and human diseases.

    Description of research:

    Telomerase is required to maintain telomeres, the protective cap at the end of chromosomes, in all eukaryotic cells. In mammals, including humans, some somatic cells in adults lack telomerase, and as a consequence, telomeres gradually short during cell division and as a function of age. Stem cells are required to replenish dead or damaged cells throughout life, and therefore telomerase is thought to play an important role in stem cell survival. While telomerase is indeed detectable in many types of human stem cells (unlike mature somatic cells), in some cases, such as in the blood, there isn't sufficient telomerase to maintain telomere length as these cells divide, and as a consequence, telomeres shorten in all blood cells during aging. On the other hand, male germ cells do have sufficient telomerase to thwart telomere loss during aging. One of the primary goals in my lab is to get a better understanding as to how telomerase activity levels are regulated in different types of stem cells. Recently, we have performed a screen for transcriptional regulators in embryonic stem cells and found that the transcription factor Hypoxia Inducible Factor 1 alpha (Hif1alpha) is essential for maintenance of functional levels of telomerase in these cells. One of the future goals of our work is get a better understanding as to the role of Hif1alpha in regulating telomerase in other types of stem cells. My lab is also interested in evaluating the therapeutic potential of using stem cells, particularly stem cells derived from the adipose, which is one of the most practical source of stem cells in adults, to treat cardiac infarcts using a murine model system.


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    F32CA076708     (ALLSOPP, RICHARD C)Mar 21, 1998
    NIH
    TELOMERAE IN MOUSE HEMATOPOIETIC STEM CELLS
    Role: Principal Investigator
    R01AG037475     (ALLSOPP, RICHARD C)Sep 1, 2011 - May 31, 2016
    NIH
    Analysis of Hif1alpha-mediated Regulation of Telomerase & Telomeres in Stem Cells
    Role: Principal Investigator
    R21AG042908     (WILLCOX, BRADLEY JOHN)Sep 1, 2013 - May 31, 2016
    NIH
    Genetics of Telomere Dynamics in Okinawans
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Medoro A, Davinelli S, Milella L, Willcox BJ, Allsopp RC, Scapagnini G, Willcox DC. Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis. Mar Drugs. 2023 Dec 16; 21(12). PMID: 38132964.
      Citations:    Fields:    Translation:HumansCells
    2. Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. 2024 Feb; 46(1):795-816. PMID: 38041783.
      Citations:    Fields:    Translation:Animals
    3. Nakagawa K, Chen R, Ross GW, Donlon TA, Allsopp RC, Willcox DC, Morris BJ, Willcox BJ, Masaki KH. FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk. J Hypertens. 2024 Mar 01; 42(3):484-489. PMID: 38009316.
      Citations:    Fields:    Translation:Humans
    4. Kallianpur KJ, Masaki KH, Chen R, Willcox BJ, Allsopp RC, Davy P, Dodge HH. Weak Social Networks in Late Life Predict Incident Alzheimer's Disease: The Kuakini Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci. 2023 03 30; 78(4):663-672. PMID: 36208464.
      Citations: 2     Fields:    Translation:Humans
    5. Chen R, Morris BJ, Donlon TA, Ross GW, Kallianpur KJ, Allsopp RC, Nakagawa K, Willcox BJ, Masaki KH. Incidence of Alzheimer's Disease in Men with Late-Life Hypertension Is Ameliorated by FOXO3 Longevity Genotype. J Alzheimers Dis. 2023; 95(1):79-91. PMID: 37483002.
      Citations: 1     Fields:    Translation:Humans
    6. Donlon TA, Morris BJ, Masaki KH, Chen R, Davy PMC, Kallianpur KJ, Nakagawa K, Owens JB, Willcox DC, Allsopp RC, Willcox BJ. FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1479-1484. PMID: 35960854.
      Citations:    Fields:    Translation:Animals
    7. Klinpudtan N, Allsopp RC, Kabayama M, Godai K, Gondo Y, Masui Y, Akagi Y, Srithumsuk W, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Ikebe K, Yasumoto S, Ogawa M, Ishizaki T, Arai Y, Rakugi H, Chen R, Willcox BJ, Willcox DC, Kamide K. The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1542-1548. PMID: 34254639.
      Citations: 4     Fields:    Translation:Humans
    8. Nakagawa K, Chen R, Greenberg SM, Ross GW, Willcox BJ, Donlon TA, Allsopp RC, Willcox DC, Morris BJ, Masaki KH. Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage. J Hypertens. 2022 11 01; 40(11):2230-2235. PMID: 35943066.
      Citations: 1     Fields:    Translation:Humans
    9. Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, Harries LW. Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. Geroscience. 2022 Apr; 44(2):1169-1170. PMID: 34637109.
      Citations: 1     Fields:    
    10. Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, Harries LW. Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. Geroscience. 2022 04; 44(2):1129-1140. PMID: 34436732.
      Citations:    Fields:    Translation:Humans
    11. Donlon TA, Chen R, Masaki KH, Willcox DC, Allsopp RC, Willcox BJ, Morris BJ. Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension. Aging (Albany NY). 2021 06 01; 13(11):14745-14767. PMID: 34074802.
      Citations: 4     Fields:    Translation:Humans
    12. Watanabe K, Higa M, Hasegawa Y, Kudo A, Allsopp RC, Willcox BJ, Willcox DC, Sata M, Masuzaki H, Shimabukuro M. Regional Variations of Insulin Secretion and Insulin Sensitivity in Japanese Participants With Normal Glucose Tolerance. Front Nutr. 2021; 8:632422. PMID: 33829033.
      Citations:    
    13. Morris BJ, Chen R, Donlon TA, Masaki KH, Willcox DC, Allsopp RC, Willcox BJ. Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. Aging (Albany NY). 2021 03 19; 13(6):7953-7974. PMID: 33739303.
      Citations: 4     Fields:    Translation:Humans
    14. Allsopp R. Take a Ride on the Telomere-Aging Train. J Gerontol A Biol Sci Med Sci. 2021 01 01; 76(1):1-2. PMID: 33355657.
      Citations: 2     Fields:    Translation:HumansCells
    15. Chen R, Morris BJ, Donlon TA, Masaki KH, Willcox DC, Davy PMC, Allsopp RC, Willcox BJ. FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease. Aging (Albany NY). 2020 12 01; 12(23):23509-23524. PMID: 33260156.
      Citations: 12     Fields:    Translation:Humans
    16. Sorrenti V, Davinelli S, Scapagnini G, Willcox BJ, Allsopp RC, Willcox DC. Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. Mar Drugs. 2020 Jul 05; 18(7). PMID: 32635607.
      Citations: 20     Fields:    Translation:Humans
    17. Igari R, Davy P, Sato H, Takahashi Y, Iseki C, Kato H, Sato H, Koyama S, Ishizawa K, Allsopp R, Kato T. Cognitive impairment, brain ischemia and shorter telomeres are predictors of mortality in the Japanese elderly: A 13-year prospective community-based study. J Neurol Sci. 2019 02 15; 397:129-134. PMID: 30616055.
      Citations: 2     Fields:    Translation:HumansCells
    18. Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tiirikainen M, Willcox BJ. Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1459-1464. PMID: 29300832.
      Citations: 16     Fields:    Translation:Humans
    19. Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky RL, Morris BJ, Lim E, Allsopp RC, Willcox BJ. Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1448-1452. PMID: 29688278.
      Citations: 4     Fields:    Translation:HumansCells
    20. Davy PMC, Allsopp RC, Donlon TA, Morris BJ, Willcox DC, Willcox BJ. FOXO3 and Exceptional Longevity: Insights From Hydra to Humans. Curr Top Dev Biol. 2018; 127:193-212. PMID: 29433738.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Donlon TA, Morris BJ, He Q, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tranah GJ, Parimi N, Evans DS, Flachsbart F, Nebel A, Kim DH, Park J, Willcox BJ. Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1038-1044. PMID: 27365368.
      Citations: 7     Fields:    Translation:Humans
    22. Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Elliott A, Willcox BJ. FOXO3 longevity interactome on chromosome 6. Aging Cell. 2017 10; 16(5):1016-1025. PMID: 28722347.
      Citations: 28     Fields:    Translation:HumansCells
    23. Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):724-728. PMID: 27694344.
      Citations: 22     Fields:    Translation:Humans
    24. Broady AJ, Loichinger MH, Ahn HJ, Davy PM, Allsopp RC, Bryant-Greenwood GD. Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation. Placenta. 2017 02; 50:44-52. PMID: 28161061.
      Citations: 16     Fields:    Translation:HumansCells
    25. Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC. Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS One. 2016; 11(5):e0154309. PMID: 27148974.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Tong HI, Kang W, Davy PM, Shi Y, Sun S, Allsopp RC, Lu Y. Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System. PLoS One. 2016; 11(4):e0154022. PMID: 27115998.
      Citations: 17     Fields:    Translation:AnimalsCells
    27. Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA. The FoxO3 gene and cause-specific mortality. Aging Cell. 2016 08; 15(4):617-24. PMID: 27071935.
      Citations: 33     Fields:    Translation:Humans
    28. Mathews J, Davy PM, Gardner LH, Allsopp RC. Stem cells, telomerase regulation and the hypoxic state. Front Biosci (Landmark Ed). 2016 01 01; 21(2):303-15. PMID: 26709774.
      Citations: 1     Fields:    Translation:HumansCells
    29. Davy PM, Lye KD, Mathews J, Owens JB, Chow AY, Wong L, Moisyadi S, Allsopp RC. Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial infarction. Stem Cells Cloning. 2015; 8:135-48. PMID: 26604802.
      Citations:    
    30. Morris BJ, Carnes BA, Chen R, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Allsopp R, Willcox BJ. Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry. Am J Hypertens. 2015 Apr; 28(4):508-17. PMID: 25249372.
      Citations: 6     Fields:    Translation:Humans
    31. Morris BJ, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Allsopp R, Willcox BJ. Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. J Gerontol A Biol Sci Med Sci. 2015 Feb; 70(2):133-42. PMID: 24589862.
      Citations: 10     Fields:    Translation:Humans
    32. Owens JB, Mathews J, Davy P, Stoytchev I, Moisyadi S, Allsopp R. Effective Targeted Gene Knockdown in Mammalian Cells Using the piggyBac Transposase-based Delivery System. Mol Ther Nucleic Acids. 2013 Dec 10; 2:e137. PMID: 24326734.
      Citations:    
    33. Allsopp R. Short telomeres flirt with stem cell commitment. Cell Stem Cell. 2013 Apr 04; 12(4):383-4. PMID: 23561436.
      Citations: 1     Fields:    
    34. Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One. 2013; 8(3):e58423. PMID: 23516479.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    35. Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H. Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting. Allergy. 2012 Sep; 67(9):1111-7. PMID: 22844983.
      Citations: 50     Fields:    Translation:Humans
    36. Allsopp R. Telomere length and iPSC re-programming: survival of the longest. Cell Res. 2012 Apr; 22(4):614-5. PMID: 22212477.
      Citations: 14     Fields:    Translation:HumansCells
    37. Davy P, Allsopp R. Hypoxia: are stem cells in it for the long run? Cell Cycle. 2011 Jan 15; 10(2):206-11. PMID: 21239881.
      Citations: 13     Fields:    Translation:AnimalsCells
    38. Chang E, Forsberg EC, Wu J, Prohaska SS, Allsopp R, Weissman IL, Cooke JP. Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease? Vasc Med. 2010 Oct; 15(5):375-85. PMID: 20926497.
      Citations: 11     Fields:    Translation:AnimalsCells
    39. Coussens M, Davy P, Brown L, Foster C, Andrews WH, Nagata M, Allsopp R. RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13842-7. PMID: 20643931.
      Citations: 23     Fields:    Translation:AnimalsCells
    40. Reitamo S, Allsopp R. Treatment with twice-weekly tacrolimus ointment in patients with moderate to severe atopic dermatitis: results from two randomized, multicentre, comparative studies. J Dermatolog Treat. 2010 Jan; 21(1):34-44. PMID: 20055695.
      Citations: 8     Fields:    Translation:Humans
    41. Meznikova M, Erdmann N, Allsopp R, Harrington LA. Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Dis Model Mech. 2009 Nov-Dec; 2(11-12):620-6. PMID: 19841238.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    42. Squires JE, Davy P, Berry MJ, Allsopp R. Attenuated expression of SECIS binding protein 2 causes loss of telomeric reserve without affecting telomerase. Exp Gerontol. 2009 Sep; 44(9):619-23. PMID: 19563878.
      Citations: 4     Fields:    Translation:HumansCells
    43. Davy P, Allsopp R. Balancing out the ends during iPSC nuclear reprogramming. Cell Stem Cell. 2009 Feb 06; 4(2):95-6. PMID: 19200794.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    44. Coussens M, Maresh JG, Yanagimachi R, Maeda G, Allsopp R. Sirt1 deficiency attenuates spermatogenesis and germ cell function. PLoS One. 2008 Feb 13; 3(2):e1571. PMID: 18270565.
      Citations: 61     Fields:    Translation:AnimalsCells
    45. Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol Biol Cell. 2008 Mar; 19(3):1210-9. PMID: 18184747.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    46. Coussens M, Yamazaki Y, Moisyadi S, Suganuma R, Yanagimachi R, Allsopp R. Regulation and effects of modulation of telomerase reverse transcriptase expression in primordial germ cells during development. Biol Reprod. 2006 Nov; 75(5):785-91. PMID: 16899651.
      Citations: 11     Fields:    Translation:AnimalsCells
    47. Allsopp R, Shimoda J, Easa D, Ward K. Long telomeres in the mature human placenta. Placenta. 2007 Apr; 28(4):324-7. PMID: 16806460.
      Citations: 14     Fields:    Translation:HumansCells
    48. Allsopp R. The two faces of telomerase. Hawaii Med J. 2005 Feb; 64(2):50-1. PMID: 15871571.
      Citations:    Fields:    Translation:Humans
    49. Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med. 2003 Apr; 9(4):369-71. PMID: 12669037.
      Citations: 42     Fields:    Translation:AnimalsCells
    50. Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003 Jul 15; 102(2):517-20. PMID: 12663456.
      Citations: 120     Fields:    Translation:AnimalsCells
    51. Allsopp RC, Weissman IL. Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? Oncogene. 2002 May 13; 21(21):3270-3. PMID: 12032768.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
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