Suppressor of Cytokine Signaling Proteins

"Suppressor of Cytokine Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.

Descriptor ID	D050826
MeSH Number(s)	D12.644.360.024.374 D12.776.157.057.249 D12.776.476.024.437
Concept/Terms	Suppressor of Cytokine Signaling Proteins Suppressor of Cytokine Signaling Proteins Suppressors of Cytokine Signaling Proteins SOCS Proteins

Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Suppressor of Cytokine Signaling Proteins [D12.644.360.024.374]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Suppressor of Cytokine Signaling Proteins [D12.776.157.057.249]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Suppressor of Cytokine Signaling Proteins [D12.776.476.024.437]

Below are MeSH descriptors whose meaning is related to "Suppressor of Cytokine Signaling Proteins".

Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling Proteins".

Suppressor of Cytokine Signaling Proteins
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling 3 Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Suppressor of Cytokine Signaling Proteins" by people in this website by year, and whether "Suppressor of Cytokine Signaling Proteins" was a major or minor topic of these publications.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 2002 and 2004 and 2012 and 2013 and 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2012	0	1	1
2013	1	0	1
2018	1	0	1
2019	1	0	1

Below are the most recent publications written about "Suppressor of Cytokine Signaling Proteins" by people in Profiles.

Mekbib T, Suen TC, Rollins-Hairston A, DeBruyne JP. The E3 Ligases Spsb1 and Spsb4 Regulate RevErba Degradation and Circadian Period. J Biol Rhythms. 2019 12; 34(6):610-621.

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Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y. CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts. Allergol Int. 2019 Jan; 68(1):101-109.

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Pozzebon ME, Varadaraj A, Mattoscio D, Jaffray EG, Miccolo C, Galimberti V, Tommasino M, Hay RT, Chiocca S. BC-box protein domain-related mechanism for VHL protein degradation. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18168-73.

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Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B. Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature. 2012 Oct 25; 490(7421):556-60.

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Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, Bansal A, Goepfert PA, Wynn KK, Ladell K, Price DA, N M, Kan-Mitchell J, Shankar P. Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA. Mol Ther. 2010 Nov; 18(11):2028-37.

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Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB. SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. Mol Cell Biol. 2004 Oct; 24(20):9092-101.

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Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P. Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2175-80.

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