A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

Descriptor ID	D056892
MeSH Number(s)	D05.500.374 D12.644.360.024.309 D12.776.157.057.072 D12.776.476.024.388 D12.776.660.551
Concept/Terms	Mediator Complex Mediator Complex Mediator Transcription Complex Thyroid Hormone-Associated Protein Complex Thyroid Hormone-Associated Protein Complex Thyroid Hormone Associated Protein Complex TRAP (Thyroid Hormone Associated Protein) Complex TR-Associated Protein (TRAP) Complex Mediator-Like Complexes Mediator-Like Complexes Mediator Like Complexes Mediator-Like Complex Mediator Like Complex

Below are MeSH descriptors whose meaning is more general than "Mediator Complex".

Below are MeSH descriptors whose meaning is related to "Mediator Complex".

Below are MeSH descriptors whose meaning is more specific than "Mediator Complex".