Proto-Oncogene Proteins c-myc

"Proto-Oncogene Proteins c-myc" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Basic helix-loop-helix transcription factors encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.

Descriptor ID	D016271
MeSH Number(s)	D12.776.260.103.813 D12.776.624.664.700.189 D12.776.660.765 D12.776.930.125.813
Concept/Terms	Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins c-myc Proto Oncogene Proteins c myc myc Proto-Oncogene Product p62 myc Proto Oncogene Product p62 Proto-Oncogene Proteins myc Proteins myc, Proto-Oncogene Proto Oncogene Proteins myc myc, Proto-Oncogene Proteins p62 c-myc p62 c myc p62(c-myc) Proto-Oncogene Products c-myc Proto Oncogene Products c myc c-myc Proteins c myc Proteins myc Proto-Oncogene Proteins Proto-Oncogene Proteins, myc myc Proto Oncogene Proteins N-myc Proteins N-myc Proteins N myc Proteins L-myc Proteins L-myc Proteins L myc Proteins

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-myc".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Proto-Oncogene Proteins c-myc [D12.776.260.103.813]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
Nuclear Proteins [D12.776.660]
Proto-Oncogene Proteins c-myc [D12.776.660.765]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Proto-Oncogene Proteins c-myc [D12.776.930.125.813]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-myc".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-myc".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-myc" by people in this website by year, and whether "Proto-Oncogene Proteins c-myc" was a major or minor topic of these publications.

Bar chart showing 47 publications over 17 distinct years, with a maximum of 6 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	2	0	2
2003	0	1	1
2005	2	2	4
2006	2	1	3
2007	3	2	5
2008	1	0	1
2009	1	1	2
2010	1	0	1
2011	2	4	6
2012	0	1	1
2013	1	1	2
2014	2	1	3
2015	4	1	5
2018	3	0	3
2019	1	4	5
2025	1	1	2

Below are the most recent publications written about "Proto-Oncogene Proteins c-myc" by people in Profiles.

Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology. 2026 Feb 01; 83(2):231-248.

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Yang C, Pang X, Teng S, Wilson S, Gu X, Xie G. MYC Overexpression Enhances Sensitivity to MEK Inhibition in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2025 Jan 12; 26(2).

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Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Elife. 2019 09 03; 8.

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Majem B, Parrilla A, Jim?nez C, Su?rez-Cabrera L, Barber M, Mar?n A, Castellv? J, Tamayo G, Moreno-Bueno G, Ponce J, Matias-Guiu X, Alameda F, Romero I, S?nchez JL, P?rez-Benavente A, Moran S, Esteller M, Revent?s J, Rigau M, Gil-Moreno A, Segura MF, Santamar?a A. MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways. Oncogene. 2019 08; 38(32):6035-6050.

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Young LA, O'Connor LO, de Renty C, Veldman-Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya-Mendoza A, Reimer C, Bartek J, Lau A, O'Connor MJ. Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress. Cancer Res. 2019 07 15; 79(14):3762-3775.

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Acevedo-D?az A, Ortiz-Soto G, Su?rez-Arroyo IJ, Zayas-Santiago A, Mart?nez Montemayor MM. Ganoderma lucidum Extract Reduces the Motility of Breast Cancer Cells Mediated by the RAC?Lamellipodin Axis. Nutrients. 2019 May 19; 11(5).

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Elliott B, Millena AC, Matyunina L, Zhang M, Zou J, Wang G, Zhang Q, Bowen N, Eaton V, Webb G, Thompson S, McDonald J, Khan S. Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells. Cancer Lett. 2019 04 28; 448:155-167.

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Choi W, Kim J, Park J, Lee DH, Hwang D, Kim JH, Ashktorab H, Smoot D, Kim SY, Choi C, Koh GY, Lim DS. YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC. Cancer Res. 2018 06 15; 78(12):3306-3320.

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Khan F, Ricks-Santi LJ, Zafar R, Kanaan Y, Naab T. Expression of p27 and c-Myc by immunohistochemistry in breast ductal cancers in African American women. Ann Diagn Pathol. 2018 Jun; 34:170-174.

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Naab TJ, Gautam A, Ricks-Santi L, Esnakula AK, Kanaan YM, DeWitty RL, Asgedom G, Makambi KH, Abawi M, Blancato JK. MYC amplification in subtypes of breast cancers in African American women. BMC Cancer. 2018 03 09; 18(1):274.

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