"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
| Descriptor ID |
D056926
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
|
| Concept/Terms |
CLOCK Proteins- CLOCK Proteins
- Circadian Locomotor Output Cycles Kaput Proteins
- CLOCK Protein
|
Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".
Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".
This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.
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Mekbib T, Suen TC, Rollins-Hairston A, DeBruyne JP. The E3 Ligases Spsb1 and Spsb4 Regulate RevErba Degradation and Circadian Period. J Biol Rhythms. 2019 12; 34(6):610-621.
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DeVera C, Baba K, Tosini G. Retinal Circadian Clocks are Major Players in the Modulation of Retinal Functions and Photoreceptor Viability. Yale J Biol Med. 2019 06; 92(2):233-240.
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Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G. Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):4856-4870.
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Baba K, Ribelayga CP, Michael Iuvone P, Tosini G. The Retinal Circadian Clock and Photoreceptor Viability. Adv Exp Med Biol. 2018; 1074:345-350.
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Riestra P, Gebreab SY, Xu R, Khan RJ, Gaye A, Correa A, Min N, Sims M, Davis SK. Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study. BMC Genet. 2017 06 23; 18(1):58.
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Owino S, Contreras-Alcantara S, Baba K, Tosini G. Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. PLoS One. 2016; 11(1):e0148214.
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McCarthy MJ, Le Roux MJ, Wei H, Beesley S, Kelsoe JR, Welsh DK. Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology. 2016 Feb; 101:439-48.
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Takahashi JS, Kumar V, Nakashe P, Koike N, Huang HC, Green CB, Kim TK. ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals. Methods Enzymol. 2015; 551:285-321.
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Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, Takahashi JS. Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science. 2012 Oct 19; 338(6105):349-54.
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Dallmann R, DeBruyne JP, Weaver DR. Photic resetting and entrainment in CLOCK-deficient mice. J Biol Rhythms. 2011 Oct; 26(5):390-401.