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Gianluca Tosini

TitleChairman, Pharmacology and Toxicology
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentPharmacology & Toxicology
Address720 Westview Drive, SW
Atlanta ga 30310
Phone4047565214
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    Other Positions
    TitleProfessor (adjunt)
    InstitutionEmory School of medicine
    DepartmentOphthalmology


    Collapse Research 
    Collapse research activities and funding
    S11NS038483     (TOSINI, GIANLUCA)Apr 15, 1999 - Mar 31, 2005
    NIH
    PLASTICITY OF MAMMALIAN CIRCADIAN AXIS
    Role: Principal Investigator
    R01NS043459     (TOSINI, GIANLUCA)Apr 1, 2002 - Aug 14, 2011
    NIH
    Photic and Circadian Regulation of Retinal Melatonin
    Role: Principal Investigator
    R56NS043459     (TOSINI, GIANLUCA)Apr 1, 2002 - Jul 31, 2012
    NIH
    Photic and circadian regulation of retinal melatonin
    Role: Principal Investigator
    T32HL103104     (QUARSHIE, ALEXANDER)Jun 1, 2010 - May 31, 2022
    NIH
    T32 Training Program for Institutions That Promote Diversity from Morehouse School of Medicine
    Role: Co-Principal Investigator
    R21EY020821     (TOSINI, GIANLUCA)Jul 1, 2010 - Jun 30, 2013
    NIH
    Circadian Regulation of the PER2::LUC Bioluminescence Rhythm in the Mouse RPE
    Role: Principal Investigator
    R01EY022216     (TOSINI, GIANLUCA)Jan 1, 2012 - Dec 31, 2016
    NIH
    Photic and Circadian Regulation of Retinal Melatonin
    Role: Principal Investigator
    R01EY026291     (TOSINI, GIANLUCA)Aug 1, 2016 - Jul 31, 2021
    NIH
    Circadian regulation of RPE functions
    Role: Principal Investigator
    R21EY031821     (TOSINI, GIANLUCA)May 1, 2021 - Apr 30, 2024
    NIH
    Melatonin Signaling in Photoreceptors
    Role: Principal Investigator
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    support@rtrn.net.
    Gianluca Tosini Laboratory

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Duong HA, Baba K, DeBruyne JP, Davidson AJ, Ehlen C, Powell M, Tosini G. Environmental circadian disruption re-writes liver circadian proteomes. Nat Commun. 2024 Jul 01; 15(1):5537. PMID: 38956413.
      Citations:    Fields:    Translation:AnimalsCells
    2. Felder-Schmittbuhl MP, Hicks D, Ribelayga CP, Tosini G. Melatonin in the mammalian retina: Synthesis, mechanisms of action and neuroprotection. J Pineal Res. 2024 04; 76(3):e12951. PMID: 38572848.
      Citations:    Fields:    Translation:AnimalsCells
    3. Duong HA, Baba K, DeBruyne JP, Davidson AJ, Ehlen C, Powell M, Tosini G. Environmental circadian disruption re-programs liver circadian gene expression. bioRxiv. 2023 Aug 29. PMID: 37693605.
      Citations:    
    4. Baba K, Suen TC, Goyal V, Stowie A, Davidson A, DeBruyne J, Tosini G. The circadian clock mediates the response to oxidative stress in a cone photoreceptor?like (661W) cell line via regulation of glutathione peroxidase activity. F1000Res. 2022; 11:1072. PMID: 36405557.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Mekbib T, Suen TC, Rollins-Hairston A, Smith K, Armstrong A, Gray C, Owino S, Baba K, Baggs JE, Ehlen JC, Tosini G, DeBruyne JP. "The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism". PLoS Genet. 2022 07; 18(7):e1010305. PMID: 35789210.
      Citations: 4     Fields:    Translation:Animals
    6. DeVera C, Dixon J, Chrenek MA, Baba K, Le YZ, Iuvone PM, Tosini G. The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity. Int J Mol Sci. 2022 May 10; 23(10). PMID: 35628111.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Tosini G. Blue-light-blocking Lenses in Eyeglasses: A Question of Timing. Optom Vis Sci. 2022 03 01; 99(3):228-229. PMID: 35058402.
      Citations: 1     Fields:    Translation:Humans
    8. Baba K, Goyal V, Tosini G. Circadian Regulation of Retinal Pigment Epithelium Function. Int J Mol Sci. 2022 Feb 28; 23(5). PMID: 35269840.
      Citations: 6     Fields:    Translation:Cells
    9. Baba K, Tosini G. Real-Time Monitoring of Circadian Rhythms in the Eye. Methods Mol Biol. 2022; 2550:367-375. PMID: 36180706.
      Citations:    Fields:    Translation:Animals
    10. Baba K, Tosini G. Assessing the Role of Melatonin in the Modulation of Visual Functions in the Mouse. Methods Mol Biol. 2022; 2550:377-389. PMID: 36180707.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Tchio C, Musani SK, Quarshie A, Tosini G. Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study. BMC Med Genomics. 2021 May 21; 14(1):136. PMID: 34020621.
      Citations: 2     Fields:    Translation:Humans
    12. Goyal V, DeVera C, Baba K, Sellers J, Chrenek MA, Iuvone PM, Tosini G. Photoreceptor Degeneration in Homozygous Male Per2luc Mice During Aging. J Biol Rhythms. 2021 04; 36(2):137-145. PMID: 33135952.
      Citations: 3     Fields:    Translation:Animals
    13. Tchio C, Baba K, Piccione G, Tosini G. Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption. Endocrinol Diabetes Metab. 2021 01; 4(1):e00171. PMID: 33532613.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Li Y, Ma J, Yao K, Su W, Tan B, Wu X, Huang X, Li T, Yin Y, Tosini G, Yin J. Circadian rhythms and obesity: Timekeeping governs lipid metabolism. J Pineal Res. 2020 Oct; 69(3):e12682. PMID: 32656907.
      Citations: 49     Fields:    Translation:HumansAnimals
    15. Yin J, Li Y, Han H, Ma J, Liu G, Wu X, Huang X, Fang R, Baba K, Bin P, Zhu G, Ren W, Tan B, Tosini G, He X, Li T, Yin Y. Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet. mSystems. 2020 May 19; 5(3). PMID: 32430404.
      Citations: 42     Fields:    
    16. Goyal V, DeVera C, Laurent V, Sellers J, Chrenek MA, Hicks D, Baba K, Iuvone PM, Tosini G. Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2020 05 11; 61(5):10. PMID: 32396631.
      Citations: 12     Fields:    Translation:AnimalsCells
    17. DeVera C, Tosini G. Circadian analysis of the mouse retinal pigment epithelium transcriptome. Exp Eye Res. 2020 04; 193:107988. PMID: 32105725.
      Citations: 9     Fields:    Translation:AnimalsCells
    18. S?nchez-Breta?o A, Suen TC, Baba K, DeBruyne J, Tosini G. Melatonin receptor heterodimerization in a photoreceptor-like cell line endogenously expressing melatonin receptors. Mol Vis. 2019; 25:791-799. PMID: 31819341.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Owino S, Buonfiglio DDC, Tchio C, Tosini G. Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism. Front Endocrinol (Lausanne). 2019; 10:488. PMID: 31379753.
      Citations: 24     Fields:    
    20. DeVera C, Baba K, Tosini G. Retinal Circadian Clocks are Major Players in the Modulation of Retinal Functions and Photoreceptor Viability. Yale J Biol Med. 2019 06; 92(2):233-240. PMID: 31249484.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    21. Buonfiglio D, Tchio C, Furigo I, Donato J, Baba K, Cipolla-Neto J, Tosini G. Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus. J Pineal Res. 2019 Sep; 67(2):e12580. PMID: 30968433.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH. Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency. J Pineal Res. 2019 Apr; 66(3):e12553. PMID: 30618149.
      Citations: 23     Fields:    Translation:Animals
    23. Baba K, Piano I, Lyuboslavsky P, Chrenek MA, Sellers JT, Zhang S, Gargini C, He L, Tosini G, Iuvone PM. Removal of clock gene Bmal1 from the retina affects retinal development and accelerates cone photoreceptor degeneration during aging. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):13099-13104. PMID: 30498030.
      Citations: 26     Fields:    Translation:AnimalsCells
    24. Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G. Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):4856-4870. PMID: 30347082.
      Citations: 30     Fields:    Translation:HumansAnimals
    25. Piano I, Baba K, Tosini G. Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKC? in mice. Exp Eye Res. 2018 12; 177:50-54. PMID: 30059666.
      Citations: 4     Fields:    Translation:AnimalsCells
    26. Baba K, Tosini G. Aging Alters Circadian Rhythms in the Mouse Eye. J Biol Rhythms. 2018 08; 33(4):441-445. PMID: 29940798.
      Citations: 15     Fields:    Translation:Animals
    27. Owino S, S?nchez-Breta?o A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G. Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res. 2018 Apr; 64(3). PMID: 29247541.
      Citations: 22     Fields:    Translation:HumansAnimals
    28. Baba K, Ribelayga CP, Michael Iuvone P, Tosini G. The Retinal Circadian Clock and Photoreceptor Viability. Adv Exp Med Biol. 2018; 1074:345-350. PMID: 29721962.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. S?nchez-Breta?o A, Baba K, Janjua U, Piano I, Gargini C, Tosini G. Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Mol Vis. 2017; 23:844-852. PMID: 29259391.
      Citations: 9     Fields:    Translation:AnimalsCells
    30. Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone PM, Spessert R. Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors. PLoS One. 2017; 12(10):e0187411. PMID: 29088301.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Laurent V, Sengupta A, S?nchez-Breta?o A, Hicks D, Tosini G. Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res. 2017 12; 165:90-95. PMID: 28941766.
      Citations: 21     Fields:    Translation:AnimalsCells
    32. Baba K, DeBruyne JP, Tosini G. Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium. Sci Rep. 2017 07 11; 7(1):5103. PMID: 28698578.
      Citations: 22     Fields:    Translation:AnimalsCells
    33. Vancura P, Wolloscheck T, Baba K, Tosini G, Iuvone PM, Spessert R. Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells. PLoS One. 2016; 11(10):e0164665. PMID: 27727308.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol. 2016 09; 173(18):2702-25. PMID: 27314810.
      Citations: 161     Fields:    Translation:HumansAnimals
    35. Owino S, Contreras-Alcantara S, Baba K, Tosini G. Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. PLoS One. 2016; 11(1):e0148214. PMID: 26824606.
      Citations: 29     Fields:    Translation:AnimalsCells
    36. Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016; 22:61-72. PMID: 26900325.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    37. Gianesini C, Hiragaki S, Laurent V, Hicks D, Tosini G. Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Invest Ophthalmol Vis Sci. 2016 Jan 01; 57(1):94-104. PMID: 26780313.
      Citations: 20     Fields:    Translation:AnimalsCells
    38. Kunst S, Wolloscheck T, Kelleher DK, Wolfrum U, Sargsyan SA, Iuvone PM, Baba K, Tosini G, Spessert R. Pgc-1a and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):6084-94. PMID: 26393668.
      Citations: 16     Fields:    Translation:AnimalsCells
    39. Gianesini C, Clesse D, Tosini G, Hicks D, Laurent V. Unique Regulation of the Melatonin Synthetic Pathway in the Retina of Diurnal Female Arvicanthis ansorgei (Rodentia). Endocrinology. 2015 Sep; 156(9):3292-308. PMID: 26153723.
      Citations: 4     Fields:    Translation:AnimalsCells
    40. Baba K, Davidson AJ, Tosini G. Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4753-8. PMID: 26207312.
      Citations: 20     Fields:    Translation:AnimalsCells
    41. Evans JA, Suen TC, Callif BL, Mitchell AS, Castanon-Cervantes O, Baker KM, Kloehn I, Baba K, Teubner BJ, Ehlen JC, Paul KN, Bartness TJ, Tosini G, Leise T, Davidson AJ. Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body. BMC Biol. 2015 Jun 23; 13:43. PMID: 26099272.
      Citations: 33     Fields:    Translation:AnimalsCells
    42. Hiragaki S, Baba K, Coulson E, Kunst S, Spessert R, Tosini G. Melatonin signaling modulates clock genes expression in the mouse retina. PLoS One. 2014; 9(9):e106819. PMID: 25203735.
      Citations: 33     Fields:    Translation:AnimalsCells
    43. Tosini G, Owino S, Guillaume JL, Jockers R. Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. Bioessays. 2014 Aug; 36(8):778-87. PMID: 24903552.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    44. Iuvone PM, Boatright JH, Tosini G, Ye K. N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain. Adv Exp Med Biol. 2014; 801:765-71. PMID: 24664769.
      Citations: 14     Fields:    Translation:Animals
    45. McMahon DG, Iuvone PM, Tosini G. Circadian organization of the mammalian retina: from gene regulation to physiology and diseases. Prog Retin Eye Res. 2014 Mar; 39:58-76. PMID: 24333669.
      Citations: 86     Fields:    Translation:AnimalsCells
    46. Baba K, Benleulmi-Chaachoua A, Journ? AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal. 2013 Oct 08; 6(296):ra89. PMID: 24106342.
      Citations: 70     Fields:    Translation:AnimalsCells
    47. Tosini G, Iuvone M, Boatright JH. Is the melatonin receptor type 1 involved in the pathogenesis of glaucoma? J Glaucoma. 2013 Jun-Jul; 22 Suppl 5:S49-50. PMID: 23733129.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    48. Dortch-Carnes J, Tosini G. Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells. Exp Eye Res. 2013 Feb; 107:1-10. PMID: 23201027.
      Citations: 7     Fields:    Translation:HumansCells
    49. Tosini G, Baba K, Hwang CK, Iuvone PM. Melatonin: an underappreciated player in retinal physiology and pathophysiology. Exp Eye Res. 2012 Oct; 103:82-9. PMID: 22960156.
      Citations: 62     Fields:    Translation:Humans
    50. Baba K, Mazzoni F, Owino S, Contreras-Alcantara S, Strettoi E, Tosini G. Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain. PLoS One. 2012; 7(5):e37799. PMID: 22629458.
      Citations: 10     Fields:    Translation:AnimalsCells
    51. Tosini G, Ye K, Iuvone PM. N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain. Neuroscientist. 2012 Dec; 18(6):645-53. PMID: 22585341.
      Citations: 20     Fields:    Translation:HumansAnimals
    52. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AF, Nishina PM, Lachapelle P, McCall MA, Koenekoop RK, Bergen AA, Kamermans M, Gregg RG. GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet. 2012 Feb 10; 90(2):331-9. PMID: 22325362.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    53. Sengupta A, Baba K, Mazzoni F, Pozdeyev NV, Strettoi E, Iuvone PM, Tosini G. Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels. PLoS One. 2011; 6(9):e24483. PMID: 21915336.
      Citations: 42     Fields:    Translation:Animals
    54. Sompol P, Liu X, Baba K, Paul KN, Tosini G, Iuvone PM, Ye K. N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8844-9. PMID: 21555574.
      Citations: 21     Fields:    Translation:AnimalsCells
    55. Alcantara-Contreras S, Baba K, Tosini G. Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse. Neurosci Lett. 2011 Apr 20; 494(1):61-4. PMID: 21362461.
      Citations: 27     Fields:    Translation:AnimalsCells
    56. Baba K, Sengupta A, Tosini M, Contreras-Alcantara S, Tosini G. Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid. Mol Vis. 2010 Dec 07; 16:2605-11. PMID: 21151601.
      Citations: 34     Fields:    Translation:AnimalsCells
    57. Pinotti M, Bertolucci C, Frigato E, Branchini A, Cavallari N, Baba K, Contreras-Alcantara S, Ehlen JC, Bernardi F, Paul KN, Tosini G. Chronic sleep deprivation markedly reduces coagulation factor VII expression. Haematologica. 2010 Aug; 95(8):1429-32. PMID: 20418241.
      Citations: 3     Fields:    Translation:AnimalsCells
    58. Contreras-Alcantara S, Baba K, Tosini G. Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity (Silver Spring). 2010 Sep; 18(9):1861-3. PMID: 20168308.
      Citations: 40     Fields:    Translation:Animals
    59. Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM, Ye K. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3876-81. PMID: 20133677.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    60. Paul KN, Saafir TB, Tosini G. The role of retinal photoreceptors in the regulation of circadian rhythms. Rev Endocr Metab Disord. 2009 Dec; 10(4):271-8. PMID: 19777353.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    61. Baba K, Pozdeyev N, Mazzoni F, Contreras-Alcantara S, Liu C, Kasamatsu M, Martinez-Merlos T, Strettoi E, Iuvone PM, Tosini G. Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):15043-8. PMID: 19706469.
      Citations: 66     Fields:    Translation:AnimalsCells
    62. Tosini G, Pozdeyev N, Sakamoto K, Iuvone PM. The circadian clock system in the mammalian retina. Bioessays. 2008 Jul; 30(7):624-33. PMID: 18536031.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    63. Pozdeyev N, Tosini G, Li L, Ali F, Rozov S, Lee RH, Iuvone PM. Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina. Eur J Neurosci. 2008 May; 27(10):2691-700. PMID: 18547251.
      Citations:    
    64. Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Fo? A, Tosini G, Bernardi F, Pinotti M. Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol. 2008 May; 28(9):3070-5. PMID: 18316400.
      Citations: 41     Fields:    Translation:AnimalsCells
    65. Fukuhara C, Tosini G. Analysis of daily and circadian gene expression in the rat pineal gland. Neurosci Res. 2008 Feb; 60(2):192-8. PMID: 18067983.
      Citations: 11     Fields:    Translation:Animals
    66. Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O. Localization of a circadian clock in mammalian photoreceptors. FASEB J. 2007 Dec; 21(14):3866-71. PMID: 17621597.
      Citations: 64     Fields:    Translation:AnimalsCells
    67. Tosini G, Kasamatsu M, Sakamoto K. Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration. Brain Res. 2007 Jul 23; 1159:134-40. PMID: 17560558.
      Citations: 13     Fields:    Translation:AnimalsCells
    68. Tosini G, Aguzzi J, Bullock NM, Liu C, Kasamatsu M. Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons rat. Brain Res. 2007 May 07; 1148:76-82. PMID: 17382912.
      Citations: 8     Fields:    Translation:AnimalsCells
    69. Dunlap KL, Reynolds AJ, Tosini G, Kerr WW, Duffy LK. Seasonal and diurnal melatonin production in exercising sled dogs. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug; 147(4):863-7. PMID: 17379556.
      Citations: 6     Fields:    Translation:AnimalsCTClinical Trials
    70. Tosini G. Locomotor activity in rodents. Methods Mol Biol. 2007; 362:95-101. PMID: 17417003.
      Citations: 1     Fields:    Translation:Animals
    71. Bellingham J, Chaurasia SS, Melyan Z, Liu C, Cameron MA, Tarttelin EE, Iuvone PM, Hankins MW, Tosini G, Lucas RJ. Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol. 2006 Jul; 4(8):e254. PMID: 16856781.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    72. Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci. 2006 May; 23(9):2488-94. PMID: 16706855.
      Citations:    
    73. Aguzzi J, Bullock NM, Tosini G. Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light. J Circadian Rhythms. 2006 Apr 04; 4:6. PMID: 16594995.
      Citations:    
    74. Sakamoto K, Liu C, Kasamatsu M, Iuvone PM, Tosini G. Intraocular injection of kainic acid does not abolish the circadian rhythm of arylalkylamine N-acetyltransferase mRNA in rat photoreceptors. Mol Vis. 2006 Feb 23; 12:117-24. PMID: 16518309.
      Citations: 14     Fields:    Translation:AnimalsCells
    75. Tosini G, Chaurasia SS, Michael Iuvone P. Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina. Chronobiol Int. 2006; 23(1-2):381-91. PMID: 16687311.
      Citations: 18     Fields:    Translation:AnimalsCells
    76. Sakamoto K, Liu C, Kasamatsu M, Pozdeyev NV, Iuvone PM, Tosini G. Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells. Eur J Neurosci. 2005 Dec; 22(12):3129-36. PMID: 16367779.
      Citations:    
    77. Steele CT, Tosini G, Siopes T, Underwood H. Time keeping by the quail's eye: circadian regulation of melatonin production. Gen Comp Endocrinol. 2006 Feb; 145(3):232-6. PMID: 16277985.
      Citations: 2     Fields:    Translation:Animals
    78. Paul KN, Fukuhara C, Karom M, Tosini G, Albers HE. AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN. Brain Res Mol Brain Res. 2005 Sep 13; 139(1):129-36. PMID: 15963600.
      Citations: 12     Fields:    Translation:Animals
    79. Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res. 2005 Jul; 24(4):433-56. PMID: 15845344.
      Citations: 117     Fields:    Translation:HumansAnimals
    80. Fukuhara C, Aguzzi J, Bullock N, Tosini G. Effect of long-term exposure to constant dim light on the circadian system of rats. Neurosignals. 2005; 14(3):117-25. PMID: 16088226.
      Citations: 5     Fields:    Translation:Animals
    81. Tosini G, Aguzzi J. Effect of space flight on circadian rhythms. Adv Space Biol Med. 2005; 10:165-74. PMID: 16101107.
      Citations: 2     Fields:    Translation:HumansAnimals
    82. Chaurasia SS, Rollag MD, Jiang G, Hayes WP, Haque R, Natesan A, Zatz M, Tosini G, Liu C, Korf HW, Iuvone PM, Provencio I. Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types. J Neurochem. 2005 Jan; 92(1):158-70. PMID: 15606905.
      Citations: 62     Fields:    Translation:AnimalsCells
    83. Sakamoto K, Liu C, Tosini G. Classical photoreceptors regulate melanopsin mRNA levels in the rat retina. J Neurosci. 2004 Oct 27; 24(43):9693-7. PMID: 15509757.
      Citations: 42     Fields:    Translation:AnimalsCells
    84. Sakamoto K, Liu C, Tosini G. Circadian rhythms in the retina of rats with photoreceptor degeneration. J Neurochem. 2004 Aug; 90(4):1019-24. PMID: 15287909.
      Citations: 20     Fields:    Translation:AnimalsCells
    85. Liang J, Wessel JH, Iuvone PM, Tosini G, Fukuhara C. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport. 2004 Jun 28; 15(9):1497-500. PMID: 15194882.
      Citations: 17     Fields:    Translation:Animals
    86. Paul KN, Gamble KL, Fukuhara C, Novak CM, Tosini G, Albers HE. Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levels. Eur J Neurosci. 2004 May; 19(10):2808-14. PMID: 15147314.
      Citations:    
    87. Fukuhara C, Liu C, Ivanova TN, Chan GC, Storm DR, Iuvone PM, Tosini G. Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina. J Neurosci. 2004 Feb 25; 24(8):1803-11. PMID: 14985420.
      Citations: 41     Fields:    Translation:AnimalsCells
    88. Liu C, Fukuhara C, Wessel JH, Iuvone PM, Tosini G. Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection. Cell Tissue Res. 2004 Feb; 315(2):197-201. PMID: 14618388.
      Citations: 27     Fields:    Translation:AnimalsCells
    89. Fukuhara C, Dirden JC, Tosini G. Analysis of gene expression following norepinephrine stimulation in the rat pineal gland using DNA microarray technique. J Pineal Res. 2003 Oct; 35(3):196-203. PMID: 12932204.
      Citations: 6     Fields:    Translation:Animals
    90. Fukuhara C, Tosini G. Induction of photosensitivity in cultured rat pineal affects Aa-nat regulation. Brain Res Dev Brain Res. 2003 May 14; 142(2):219-21. PMID: 12711374.
      Citations: 2     Fields:    Translation:AnimalsCells
    91. Fukuhara C, Tosini G. Peripheral circadian oscillators and their rhythmic regulation. Front Biosci. 2003 May 01; 8:d642-51. PMID: 12700075.
      Citations: 12     Fields:    Translation:HumansAnimals
    92. Tosini G, Fukuhara C. Photic and circadian regulation of retinal melatonin in mammals. J Neuroendocrinol. 2003 Apr; 15(4):364-9. PMID: 12622835.
      Citations: 17     Fields:    Translation:AnimalsCells
    93. Paul KN, Fukuhara C, Tosini G, Albers HE. Transduction of light in the suprachiasmatic nucleus: evidence for two different neurochemical cascades regulating the levels of Per1 mRNA and pineal melatonin. Neuroscience. 2003; 119(1):137-44. PMID: 12763075.
      Citations: 9     Fields:    Translation:Animals
    94. Tosini G, Fukuhara C. The mammalian retina as a clock. Cell Tissue Res. 2002 Jul; 309(1):119-26. PMID: 12111542.
      Citations: 20     Fields:    Translation:Animals
    95. Fukuhara C, Dirden JC, Tosini G. Regulation of period 1 expression in cultured rat pineal. Neurosignals. 2002 Mar-Apr; 11(2):103-14. PMID: 12077484.
      Citations: 6     Fields:    Translation:AnimalsCells
    96. Fukuhara C, Dirden JC, Tosini G. Photic regulation of melatonin in rat retina and the role of proteasomal proteolysis. Neuroreport. 2001 Dec 04; 12(17):3833-7. PMID: 11726804.
      Citations: 10     Fields:    Translation:AnimalsCells
    97. Fukuhara C, Brewer JM, Dirden JC, Bittman EL, Tosini G, Harrington ME. Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus. Neurosci Lett. 2001 Nov 16; 314(3):119-22. PMID: 11704298.
      Citations: 16     Fields:    Translation:AnimalsCells
    98. Herzog ED, Tosini G. The mammalian circadian clock shop. Semin Cell Dev Biol. 2001 Aug; 12(4):295-303. PMID: 11463214.
      Citations: 13     Fields:    Translation:Animals
    99. Wang Y, Osterbur DL, Megaw PL, Tosini G, Fukuhara C, Green CB, Besharse JC. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. BMC Dev Biol. 2001; 1:9. PMID: 11394964.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    100. Tosini G, Bertolucci C, Fo? A. The circadian system of reptiles: a multioscillatory and multiphotoreceptive system. Physiol Behav. 2001 Mar; 72(4):461-71. PMID: 11282129.
      Citations: 16     Fields:    Translation:AnimalsCells
    101. Tosini G, Doyle S, Geusz M, Menaker M. Induction of photosensitivity in neonatal rat pineal gland. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11540-4. PMID: 11005846.
      Citations: 7     Fields:    Translation:AnimalsCells
    102. Tosini G. Melatonin circadian rhythm in the retina of mammals. Chronobiol Int. 2000 Sep; 17(5):599-612. PMID: 11023208.
      Citations: 14     Fields:    Translation:HumansAnimals
    103. Zordan M, Costa R, Macino G, Fukuhara C, Tosini G. Circadian clocks: what makes them tick? Chronobiol Int. 2000 Jul; 17(4):433-51. PMID: 10908122.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    104. Fukuhara C, Dirden JC, Tosini G. Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Neurosci Lett. 2000 Jun 09; 286(3):167-70. PMID: 10832011.
      Citations: 10     Fields:    Translation:Animals
    105. Tosini G, Dirden JC. Dopamine inhibits melatonin release in the mammalian retina: in vitro evidence. Neurosci Lett. 2000 Jun 02; 286(2):119-22. PMID: 10825651.
      Citations: 32     Fields:    Translation:AnimalsCells
    106. Tosini G, Menaker M. The tau mutation affects temperature compensation of hamster retinal circadian oscillators. Neuroreport. 1998 Apr 20; 9(6):1001-5. PMID: 9601657.
      Citations: 30     Fields:    Translation:Animals
    107. Tosini G, Menaker M. The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration. Brain Res. 1998 Apr 13; 789(2):221-8. PMID: 9573370.
      Citations: 76     Fields:    Translation:AnimalsCells
    108. Tosini G, Menaker M. Multioscillatory circadian organization in a vertebrate, iguana iguana. J Neurosci. 1998 Feb 01; 18(3):1105-14. PMID: 9437030.
      Citations: 10     Fields:    Translation:AnimalsCells
    109. Menaker M, Moreira LF, Tosini G. Evolution of circadian organization in vertebrates. Braz J Med Biol Res. 1997 Mar; 30(3):305-13. PMID: 9246228.
      Citations: 40     Fields:    Translation:Animals
    110. Tosini G, Menaker M. Circadian rhythms in cultured mammalian retina. Science. 1996 Apr 19; 272(5260):419-21. PMID: 8602533.
      Citations: 180     Fields:    Translation:Animals
    111. Tosini G, Menaker M. The pineal complex and melatonin affect the expression of the daily rhythm of behavioral thermoregulation in the green iguana. J Comp Physiol A. 1996; 179(1):135-42. PMID: 8965257.
      Citations: 10     Fields:    Translation:Animals
    112. Tosini G, Avery RA. Dermal photoreceptors regulate basking behavior in the lizard Podarcis muralis. Physiol Behav. 1996 Jan; 59(1):195-8. PMID: 8848482.
      Citations: 4     Fields:    Translation:AnimalsCells
    113. Tosini G, Menaker M. Circadian rhythm of body temperature in an ectotherm (Iguana iguana). J Biol Rhythms. 1995 Sep; 10(3):248-55. PMID: 7488762.
      Citations: 8     Fields:    Translation:Animals
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