p300-CBP Transcription Factors

"p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.

Descriptor ID	D050880
MeSH Number(s)	D08.811.913.050.134.415.500.575 D12.776.930.680
Concept/Terms	p300-CBP Transcription Factors p300-CBP Transcription Factors Transcription Factors, p300-CBP p300 CBP Transcription Factors p300-CBP Coactivator Coactivator, p300-CBP p300 CBP Coactivator p300-CBP Protein p300 CBP Protein

Below are MeSH descriptors whose meaning is more general than "p300-CBP Transcription Factors".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Acetyltransferases [D08.811.913.050.134]
Lysine Acetyltransferases [D08.811.913.050.134.415]
Histone Acetyltransferases [D08.811.913.050.134.415.500]
p300-CBP Transcription Factors [D08.811.913.050.134.415.500.575]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
p300-CBP Transcription Factors [D12.776.930.680]

Below are MeSH descriptors whose meaning is related to "p300-CBP Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "p300-CBP Transcription Factors".

p300-CBP Transcription Factors
CREB-Binding Protein
E1A-Associated p300 Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "p300-CBP Transcription Factors" by people in this website by year, and whether "p300-CBP Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	0	1	1
2007	0	1	1
2010	0	1	1
2012	2	0	2
2013	2	1	3
2014	1	0	1
2018	1	1	2
2023	0	1	1

Below are the most recent publications written about "p300-CBP Transcription Factors" by people in Profiles.

Zhong X, Deng H, Long M, Yin H, Zhong Q, Zheng S, Gong T, He L, Wang G, Sun Q. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorg Chem. 2023 09; 138:106597.

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Song X, Liu W, Yuan X, Jiang J, Wang W, Mullen M, Zhao X, Zhang Y, Liu F, Du S, Rehman A, Tian R, Li J, Frost A, Song Z, Green HN, Henry C, Liu X, Ding X, Wang D, Yao X. Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion. J Mol Cell Biol. 2018 12 01; 10(6):559-572.

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Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T. Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. J Biol Chem. 2018 05 11; 293(19):7126-7138.

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Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M. Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1914-21.

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Hoffmann C, Zimmermann A, Hinney A, Volckmar AL, Jarrett HW, Fromme T, Klingenspor M. A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes. PLoS One. 2013; 8(12):e83426.

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Knowell AE, Patel D, Morton DJ, Sharma P, Glymph S, Chaudhary J. Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer. 2013 Dec 13; 12:161.

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Xu J, Kawai Y, Arinze IJ. Dual role of C/EBPa as an activator and repressor of Gai2 gene transcription. Genes Cells. 2013 Dec; 18(12):1082-94.

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Ward T, Wang M, Liu X, Wang Z, Xia P, Chu Y, Wang X, Liu L, Jiang K, Yu H, Yan M, Wang J, Hill DL, Huang Y, Zhu T, Yao X. Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis. J Biol Chem. 2013 May 31; 288(22):15771-85.

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Xia P, Wang Z, Liu X, Wu B, Wang J, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X. EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16564-9.

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Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93.

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