Inhibitor of Differentiation Proteins

"Inhibitor of Differentiation Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.

Descriptor ID	D051796
MeSH Number(s)	D12.776.930.329
Concept/Terms	Inhibitor of Differentiation Proteins Inhibitor of Differentiation Proteins Differentiation Proteins Inhibitor ID DNA Binding Protein Inhibitor

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Differentiation Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Inhibitor of Differentiation Proteins [D12.776.930.329]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Differentiation Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Differentiation Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Differentiation Proteins" by people in this website by year, and whether "Inhibitor of Differentiation Proteins" was a major or minor topic of these publications.

Bar chart showing 20 publications over 12 distinct years, with a maximum of 3 publications in 2012 and 2013 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2005	0	1	1
2006	1	0	1
2007	1	0	1
2009	1	0	1
2011	1	0	1
2012	3	0	3
2013	3	0	3
2014	3	0	3
2015	1	0	1
2016	2	0	2
2017	2	0	2

Below are the most recent publications written about "Inhibitor of Differentiation Proteins" by people in Profiles.

Joshi JB, Patel D, Morton DJ, Sharma P, Zou J, Hewa Bostanthirige D, Gorantla Y, Nagappan P, Komaragiri SK, Sivils JC, Xie H, Palaniappan R, Wang G, Cox MB, Chaudhary J. Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol. 2017 04; 11(4):337-357.

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Morton DJ, Patel D, Joshi J, Hunt A, Knowell AE, Chaudhary J. ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget. 2017 Jan 10; 8(2):2536-2549.

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Korang-Yeboah M, Patel D, Morton D, Sharma P, Gorantla Y, Joshi J, Nagappan P, Pallaniappan R, Chaudhary J. Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth. Oncotarget. 2016 Oct 18; 7(42):68072-68085.

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Komaragiri SK, Bostanthirige DH, Morton DJ, Patel D, Joshi J, Upadhyay S, Chaudhary J. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun. 2016 09 09; 478(1):60-66.

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Sharma P, Chinaranagari S, Chaudhary J. Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity. Biochimie. 2015 May; 112:139-50.

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Patel D, Morton DJ, Carey J, Havrda MC, Chaudhary J. Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta. 2015 Jan; 1855(1):92-103.

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Chinaranagari S, Sharma P, Chaudhary J. EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer. Oncotarget. 2014 Aug 30; 5(16):7172-82.

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Patel D, Knowell AE, Korang-Yeboah M, Sharma P, Joshi J, Glymph S, Chinaranagari S, Nagappan P, Palaniappan R, Bowen NJ, Chaudhary J. Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. Mol Endocrinol. 2014 Aug; 28(8):1239-53.

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Knowell AE, Patel D, Morton DJ, Sharma P, Glymph S, Chaudhary J. Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer. 2013 Dec 13; 12:161.

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Carey JP, Knowell AE, Chinaranagari S, Chaudhary J. Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells. Anticancer Res. 2013 Oct; 33(10):4271-8.

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