E2F Transcription Factors

"E2F Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.

Descriptor ID	D050684
MeSH Number(s)	D12.776.930.211
Concept/Terms	E2F Transcription Factors E2F Transcription Factors Transcription Factors, E2F E2F Proteins Transcription Factor E2F E2F, Transcription Factor

Below are MeSH descriptors whose meaning is more general than "E2F Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.211]

Below are MeSH descriptors whose meaning is related to "E2F Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "E2F Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F Transcription Factors" by people in this website by year, and whether "E2F Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1997 and 1998 and 2001 and 2002 and 2004 and 2014 and 2018 and 2019 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
2001	0	1	1
2002	0	1	1
2004	0	1	1
2014	1	0	1
2018	1	0	1
2019	1	0	1
2021	0	1	1

Below are the most recent publications written about "E2F Transcription Factors" by people in Profiles.

Chakraborty S, Utter MB, Frias MA, Foster DA. Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin. Cancer Lett. 2021 12 01; 522:164-170.

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Jusino S, Saavedra HI. Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition. Exp Biol Med (Maywood). 2019 11; 244(16):1419-1429.

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Lee M, Gudas LJ, Saavedra HI. Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays. Methods Mol Biol. 2018; 1726:143-151.

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Lee MY, Moreno CS, Saavedra HI. E2F activators signal and maintain centrosome amplification in breast cancer cells. Mol Cell Biol. 2014 Jul; 34(14):2581-99.

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Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004 Sep 24; 279(39):40511-20.

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Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ. 2002 May; 13(5):215-25.

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Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22; 414(6862):457-62.

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Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8.

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Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene. 1997 Jul 10; 15(2):143-57.

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