E2F3 Transcription Factor

"E2F3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A. E2F3 regulates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis.

Descriptor ID	D050699
MeSH Number(s)	D12.776.930.211.750
Concept/Terms	E2F3 Transcription Factor E2F3 Transcription Factor Transcription Factor, E2F3 Transcription Factor E2F-3 E2F-3, Transcription Factor Transcription Factor E2F 3 E2F Transcription Factor 3 Protein E2F3b Transcription Factor E2F3b Transcription Factor Transcription Factor, E2F3b E2F3a Transcription Factor E2F3a Transcription Factor Transcription Factor, E2F3a

Below are MeSH descriptors whose meaning is more general than "E2F3 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.211]
E2F3 Transcription Factor [D12.776.930.211.750]

Below are MeSH descriptors whose meaning is related to "E2F3 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "E2F3 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F3 Transcription Factor" by people in this website by year, and whether "E2F3 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 1997 and 2001 and 2002 and 2003 and 2004 and 2006 and 2007 and 2013 and 2015 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	1	1
2006	1	0	1
2007	1	0	1
2013	0	1	1
2015	1	0	1
2021	1	0	1

Below are the most recent publications written about "E2F3 Transcription Factor" by people in Profiles.

Jusino S, Rivera-Rivera Y, Chard?n-Col?n C, Ruiz-Justiz AJ, V?lez-Vel?zquez J, Isidro A, Cruz-Robles ME, Bonilla-Claudio M, Armaiz-Pena GN, Saavedra HI. E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer. Exp Biol Med (Maywood). 2021 10; 246(19):2057-2071.

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Lee M, Oprea-Ilies G, Saavedra HI. Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis. Oncotarget. 2015 Nov 10; 6(35):37316-34.

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Engel BE, Welsh E, Emmons MF, Santiago-Cardona PG, Cress WD. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Cell Death Dis. 2013 Nov 28; 4:e938.

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Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, Orringer D, Trikha P, Saavedra HI, Leone G. E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol. 2007 Jan; 27(1):65-78.

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Sharma N, Timmers C, Trikha P, Saavedra HI, Obery A, Leone G. Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. J Biol Chem. 2006 Nov 24; 281(47):36124-31.

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Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004 Sep 24; 279(39):40511-20.

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Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G. Inactivation of E2F3 results in centrosome amplification. Cancer Cell. 2003 Apr; 3(4):333-46.

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Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ. 2002 May; 13(5):215-25.

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Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22; 414(6862):457-62.

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Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene. 1997 Jul 10; 15(2):143-57.

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