E2F1 Transcription Factor

"E2F1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.

Descriptor ID	D050687
MeSH Number(s)	D12.644.360.024.328.049 D12.776.157.057.158.049 D12.776.476.024.420.049 D12.776.660.769.049 D12.776.930.211.500
Concept/Terms	E2F1 Transcription Factor E2F1 Transcription Factor Transcription Factor, E2F1 Transcription Factor E2F-1 Transcription Factor E2F 1 E2F Transcription Factor 1 Protein Retinoblastoma-Associated Protein 1 Retinoblastoma Associated Protein 1 Retinoblastoma Binding Protein 3 E2F-1 Transcription Factor Transcription Factor, E2F-1 Transcription Factor E2F1

Below are MeSH descriptors whose meaning is more general than "E2F1 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Retinoblastoma Binding Proteins [D12.644.360.024.328]
E2F1 Transcription Factor [D12.644.360.024.328.049]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Retinoblastoma Binding Proteins [D12.776.157.057.158]
E2F1 Transcription Factor [D12.776.157.057.158.049]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Retinoblastoma Binding Proteins [D12.776.476.024.420]
E2F1 Transcription Factor [D12.776.476.024.420.049]
Nuclear Proteins [D12.776.660]
Retinoblastoma Binding Proteins [D12.776.660.769]
E2F1 Transcription Factor [D12.776.660.769.049]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.211]
E2F1 Transcription Factor [D12.776.930.211.500]

Below are MeSH descriptors whose meaning is related to "E2F1 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "E2F1 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F1 Transcription Factor" by people in this website by year, and whether "E2F1 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 21 publications over 18 distinct years, with a maximum of 2 publications in 2013 and 2016 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2001	0	1	1
2002	0	1	1
2004	0	1	1
2006	1	0	1
2007	1	0	1
2009	1	0	1
2011	1	0	1
2012	1	0	1
2013	0	2	2
2014	1	0	1
2015	0	1	1
2016	0	2	2
2017	0	1	1
2019	1	1	2
2020	1	0	1
2021	0	1	1
2025	0	1	1

Below are the most recent publications written about "E2F1 Transcription Factor" by people in Profiles.

Umemura K, Akiyama Y, Shimada S, Hatano M, Kono A, Yasukawa K, Kamachi A, Igarashi Y, Tsukihara S, Tanji Y, Morimoto K, Nara A, Yamane M, Akahoshi K, Ono H, Shimizu A, Soejima Y, Tanabe M, Ban D, Tanaka S. PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer. Mol Cancer Res. 2025 Oct 02; 23(10):844-858.

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Kumar S, Tchounwou PB. Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep; 36(9):1785-1792.

View in: PubMed
Altayyar MA, Sheng X, Wang Z. WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA. Mol Cell Biol. 2020 11 20; 40(24).

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Zhao Y, Kang X, Gao F, Guzman A, Lau RP, Biniwale R, Wadehra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Van Arsdell G, Coppola G, Nelson SF, Touma M. Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot. J Mol Med (Berl). 2019 12; 97(12):1711-1722.

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Folk WP, Kumari A, Iwasaki T, Pyndiah S, Johnson JC, Cassimere EK, Abdulovic-Cui AL, Sakamuro D. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin. J Biol Chem. 2019 04 05; 294(14):5700-5719.

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Kundu N, Brekman A, Kim JY, Xiao G, Gao C, Bargonetti J. Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway. Oncotarget. 2017 Jul 18; 8(29):47916-47930.

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Zhao Q, Zhao M, Parris AB, Xing Y, Yang X. Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells. Int J Oncol. 2016 Sep; 49(3):1203-10.

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Liu D, Pattabiraman V, Bacanamwo M, Anderson LM. Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase transition in vascular smooth muscle cells by CDK2-dependent activation. Am J Physiol Cell Physiol. 2016 08 01; 311(2):C179-89.

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Sosa-Garc?a B, V?zquez-Rivera V, Gonz?lez-Flores JN, Engel BE, Cress WD, Santiago-Cardona PG. The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts. PLoS One. 2015; 10(11):e0142406.

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Kumari A, Iwasaki T, Pyndiah S, Cassimere EK, Palani CD, Sakamuro D. Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. Cell Death Differ. 2015 Feb; 22(2):311-22.

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