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Xiaohe Yang

TitleProfessor
Faculty RankProfessor
InstitutionNorth Carolina Central University
DepartmentBiological and Biomedical Sciences
Address700 George Street
Durham NC 27707
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    R21ES025337     (YANG, XIAOHE)Sep 30, 2015 - Aug 31, 2018
    NIH
    Mechanisms of in utero exposure to bisphenol A induced mammary tumor risk
    Role: Principal Investigator
    R16GM145545     (YANG, XIAOHE)May 10, 2022 - Apr 30, 2026
    NIH
    In utero exposure to alcohol-induced mammary stem cell deregulation and tumor risk later in life.
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gant DMA, Parris AB, Yang X. Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells. Biochem Biophys Res Commun. 2022 07 12; 613:100-106. PMID: 35550195.
      Citations: 2     Fields:    Translation:HumansCells
    2. Shi Y, Ma Z, Cheng Q, Wu Y, Parris AB, Kong L, Yang X. FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. Biochim Biophys Acta Mol Cell Res. 2021 01; 1868(1):118877. PMID: 33007330.
      Citations: 13     Fields:    Translation:HumansCells
    3. Ma Z, Parris AB, Howard EW, Davis M, Cao X, Woods C, Yang X. In Utero Exposure to Bisphenol a Promotes Mammary Tumor Risk in MMTV-Erbb2 Transgenic Mice Through the Induction of ER-erbB2 Crosstalk. Int J Mol Sci. 2020 Apr 28; 21(9). PMID: 32353937.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    4. Yang X, Hei C, Liu P, Li PA. Prevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats. Biochem Biophys Res Commun. 2019 11 26; 520(1):47-53. PMID: 31564412.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Zhao Q, Howard EW, Parris AB, Ma Z, Xing Y, Yang X. Bisphenol AF promotes estrogen receptor-positive breast cancer cell proliferation through amphiregulin-mediated crosstalk with receptor tyrosine kinase signaling. PLoS One. 2019; 14(5):e0216469. PMID: 31059536.
      Citations: 4     Fields:    Translation:HumansCells
    6. Ma Z, Parris AB, Howard EW, Shi Y, Yang S, Jiang Y, Kong L, Yang X. Caloric restriction inhibits mammary tumorigenesis in MMTV-ErbB2 transgenic mice through the suppression of ER and ErbB2 pathways and inhibition of epithelial cell stemness in premalignant mammary tissues. Carcinogenesis. 2018 10 08; 39(10):1264-1273. PMID: 30107476.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Howard EW, Yang X. microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy. Biol Proced Online. 2018; 20:17. PMID: 30214383.
      Citations:    
    8. Ma Z, Kim YM, Howard EW, Feng X, Kosanke SD, Yang S, Jiang Y, Parris AB, Cao X, Li S, Yang X. DMBA promotes ErbB2-mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability. Oncol Rep. 2018 Sep; 40(3):1632-1640. PMID: 30015966.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Lee H, Saini N, Howard EW, Parris AB, Ma Z, Zhao Q, Zhao M, Liu B, Edgerton SM, Thor AD, Yang X. Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells. Sci Rep. 2018 05 01; 8(1):6829. PMID: 29717218.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    10. Saini N, Yang X. Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochim Biophys Sin (Shanghai). 2018 Feb 01; 50(2):133-143. PMID: 29342230.
      Citations: 71     Fields:    Translation:HumansCells
    11. Zhao Q, Parris AB, Howard EW, Zhao M, Ma Z, Guo Z, Xing Y, Yang X. FGFR inhibitor, AZD4547, impedes the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice. Sci Rep. 2017 09 12; 7(1):11306. PMID: 28900173.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. Guo Z, Zhao M, Howard EW, Zhao Q, Parris AB, Ma Z, Yang X. Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. Oncotarget. 2017 Sep 01; 8(36):60342-60357. PMID: 28947975.
      Citations: 17     Fields:    
    13. Zhao M, Howard EW, Parris AB, Guo Z, Zhao Q, Ma Z, Xing Y, Liu B, Edgerton SM, Thor AD, Yang X. Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells. Oncotarget. 2017 Aug 29; 8(35):58847-58864. PMID: 28938602.
      Citations: 6     Fields:    
    14. Lee H, Saini N, Parris AB, Zhao M, Yang X. Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. Int J Oncol. 2017 Sep; 51(3):967-974. PMID: 28713919.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Zhao M, Howard EW, Guo Z, Parris AB, Yang X. p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells. PLoS One. 2017; 12(4):e0175121. PMID: 28369097.
      Citations: 14     Fields:    Translation:HumansCells
    16. Parris AB, Zhao Q, Howard EW, Zhao M, Ma Z, Yang X. Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice. J Exp Clin Cancer Res. 2017 02 13; 36(1):28. PMID: 28193239.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Ma Z, Parris AB, Xiao Z, Howard EW, Kosanke SD, Feng X, Yang X. Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice. J Exp Clin Cancer Res. 2017 01 06; 36(1):6. PMID: 28061785.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Zhao M, Howard EW, Parris AB, Guo Z, Zhao Q, Yang X. Alcohol promotes migration and invasion of triple-negative breast cancer cells through activation of p38 MAPK and JNK. Mol Carcinog. 2017 03; 56(3):849-862. PMID: 27533114.
      Citations: 27     Fields:    Translation:HumansCells
    19. Liu P, Yang X, Hei C, Meli Y, Niu J, Sun T, Li PA. Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling. Int J Biol Sci. 2016; 12(8):1032-40. PMID: 27489506.
      Citations: 25     Fields:    Translation:AnimalsCells
    20. Zhao Q, Zhao M, Parris AB, Xing Y, Yang X. Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells. Int J Oncol. 2016 Sep; 49(3):1203-10. PMID: 27574003.
      Citations: 22     Fields:    Translation:HumansCells
    21. Yang X, Hei C, Liu P, Song Y, Thomas T, Tshimanga S, Wang F, Niu J, Sun T, Li PA. Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia. Int J Biol Sci. 2015; 11(12):1424-35. PMID: 26681922.
      Citations: 30     Fields:    Translation:Animals
    22. Li P, Zhao M, Parris AB, Feng X, Yang X. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1267-1274. PMID: 26225749.
      Citations: 32     Fields:    Translation:HumansCells
    23. Fu Y, Kadioglu O, Wiench B, Wei Z, Wang W, Luo M, Yang X, Gu C, Zu Y, Efferth T. Activity of the antiestrogenic cajanin stilbene acid towards breast cancer. J Nutr Biochem. 2015 Nov; 26(11):1273-82. PMID: 26365581.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Ma Z, Blackwelder AJ, Lee H, Zhao M, Yang X. In Utero exposure to low-dose alcohol induces reprogramming of mammary development and tumor risk in MMTV-erbB-2 transgenic mice. Int J Mol Sci. 2015 Apr 07; 16(4):7655-71. PMID: 25853264.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Zhu P, Davis M, Blackwelder AJ, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models. Cancer Prev Res (Phila). 2014 Feb; 7(2):199-210. PMID: 24322659.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    26. Huang J, Wang S, Lyu H, Cai B, Yang X, Wang J, Liu B. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells. Mol Cancer. 2013 Nov 11; 12(1):134. PMID: 24215614.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    27. Tophkhane C, Yang SH, Jiang Y, Ma Z, Subramaniam D, Anant S, Yogosawa S, Sakai T, Liu WG, Edgerton S, Thor A, Yang X. p53 inactivation upregulates p73 expression through E2F-1 mediated transcription. PLoS One. 2012; 7(8):e43564. PMID: 22952705.
      Citations: 20     Fields:    Translation:HumansCells
    28. Zhang R, Kim YM, Yang X, Li Y, Li S, Lee JY. A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient. Cancer Genet. 2011 Dec; 204(12):687-91. PMID: 22285022.
      Citations: 6     Fields:    Translation:HumansCells
    29. Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD. Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle. 2011 Sep 01; 10(17):2959-66. PMID: 21862872.
      Citations: 75     Fields:    Translation:HumansCells
    30. Kim YM, Ma Z, Lee S, Lee J, Li S, Yang X. Trisomy chromosome 5 is a recurrent cytogenetic lesion in mammary tumors from parous MMTV-erbB-2 transgenic mice. Oncol Lett. 2011 Nov; 2(6):1077-1081. PMID: 22848270.
      Citations:    
    31. Huang X, Wang S, Lee CK, Yang X, Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Lett. 2011 Aug 01; 307(1):72-79. PMID: 21497990.
      Citations: 27     Fields:    Translation:HumansCells
    32. Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y, Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep. 2011 Jun; 25(6):1713-9. PMID: 21479363.
      Citations: 18     Fields:    Translation:HumansCells
    33. Xu L, Gao J, Wang Y, Yu W, Zhao X, Yang X, Zhong Z, Qian ZM. Myrica rubra Extracts Protect the Liver from CCl(4)-Induced Damage. Evid Based Complement Alternat Med. 2011; 2011:518302. PMID: 20019074.
      Citations:    
    34. Jiang Y, Chen H, Jia H, Xu Y, Liu G, Wang Y, Yang X, Lu Y. Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions. Exp Ther Med. 2010 Mar; 1(2):363-368. PMID: 22993550.
      Citations:    
    35. Huang X, Gao L, Wang S, McManaman JL, Thor AD, Yang X, Esteva FJ, Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. Cancer Res. 2010 Feb 01; 70(3):1204-14. PMID: 20103628.
      Citations: 117     Fields:    Translation:HumansCells
    36. Yang X, Yang S, McKimmey C, Liu B, Edgerton SM, Bales W, Archer LT, Thor AD. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation. Carcinogenesis. 2010 Apr; 31(4):695-702. PMID: 20067990.
      Citations: 14     Fields:    Translation:HumansCells
    37. Tophkhane C, Yang S, Zhao ZJ, Yang X. Cell density-dependent regulation of p73 in breast cancer cells. Int J Oncol. 2009 Dec; 35(6):1429-34. PMID: 19885566.
      Citations: 2     Fields:    Translation:HumansCells
    38. Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X, Thor AD. Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res. 2009 Nov; 7(11):1882-92. PMID: 19861407.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    39. Jin W, Wang H, Yan W, Xu L, Wang X, Zhao X, Yang X, Chen G, Ji Y. Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm. 2008; 2008:725174. PMID: 19190763.
      Citations: 72     Fields:    Translation:Animals
    40. Yang H, Yang X, Pan M, Chen Y, Chen D. Functional contrast and kinetic analysis of water-dispersible carbon black nanoparticles and MWNTs in glucose biosensors. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:7204-7. PMID: 19965278.
      Citations:    Fields:    
    41. Yang H, Yang X, Chen Y, Pan M. [Microstrip antenna design and system research of radio frequency identification temperature sensor]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Dec; 25(6):1420-4. PMID: 19166222.
      Citations:    Fields:    Translation:Humans
    42. Kim YM, Yang S, Xu W, Li S, Yang X. Continuous in vitro exposure to low-dose genistein induces genomic instability in breast epithelial cells. Cancer Genet Cytogenet. 2008 Oct 15; 186(2):78-84. PMID: 18940470.
      Citations: 5     Fields:    Translation:HumansCells
    43. Tophkhane C, Yang S, Bales W, Archer L, Osunkoya A, Thor AD, Yang X. Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms. Int J Oncol. 2007 Oct; 31(4):867-74. PMID: 17786319.
      Citations: 16     Fields:    Translation:HumansCells
    44. Yang S, Liu J, Thor AD, Yang X. Caspase expression profile and functional activity in a panel of breast cancer cell lines. Oncol Rep. 2007 May; 17(5):1229-35. PMID: 17390070.
      Citations: 8     Fields:    Translation:HumansCells
    45. Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD. Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer. 2007 May 01; 120(9):1874-82. PMID: 17266042.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    46. Yang S, Zhou Q, Yang X. Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cells. Biochim Biophys Acta. 2007 Jun; 1773(6):903-11. PMID: 17490757.
      Citations: 33     Fields:    Translation:HumansCellsCTClinical Trials
    47. Yang S, Thor AD, Edgerton S, Yang X. Caspase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis. Apoptosis. 2006 Nov; 11(11):1987-97. PMID: 17013758.
      Citations: 21     Fields:    Translation:HumansCells
    48. Mungamuri SK, Yang X, Thor AD, Somasundaram K. Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res. 2006 May 01; 66(9):4715-24. PMID: 16651424.
      Citations: 97     Fields:    Translation:HumansCells
    49. Kim A, Liu B, Ordonez-Ercan D, Alvarez KM, Jones LD, McKimmey C, Edgerton SM, Yang X, Thor AD. Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells. Breast Cancer Res. 2005; 7(5):R708-18. PMID: 16168116.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    50. Liu B, Edgerton S, Yang X, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Liu N, Thor A. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res. 2005 Feb 01; 65(3):879-86. PMID: 15705886.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    51. Kosanke S, Edgerton SM, Moore D, Yang X, Mason T, Alvarez K, Jones L, Kim A, Thor AD. Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. Comp Med. 2004 Jun; 54(3):280-7. PMID: 15253274.
      Citations: 6     Fields:    Translation:AnimalsCells
    52. Yang X, Edgerton SM, Kosanke SD, Mason TL, Alvarez KM, Liu N, Chatterton RT, Liu B, Wang Q, Kim A, Murthy S, Thor AD. Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice. Cancer Res. 2003 May 15; 63(10):2425-33. PMID: 12750262.
      Citations: 24     Fields:    Translation:AnimalsCells
    53. Jeruss JS, Liu NX, Chung Y, Magrane G, Waldman F, Edgerton S, Yang X, Thor AD. Characterization and chromosomal instability of novel derived cell lines from a wt-erbB-2 transgenic mouse model. Carcinogenesis. 2003 Apr; 24(4):659-64. PMID: 12727793.
      Citations: 8     Fields:    Translation:AnimalsCells
    54. Turbov JM, Twaddle GM, Yang X, Liu NM, Murthy S. Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro. J Surg Oncol. 2002 Jan; 79(1):17-29. PMID: 11754373.
      Citations: 4     Fields:    Translation:HumansCells
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