Metformin

"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

Descriptor ID	D008687
MeSH Number(s)	D02.078.370.141.450
Concept/Terms	Metformin Metformin Dimethylbiguanidine Dimethylguanylguanidine Glucophage Glucophage Metformin Hydrochloride Metformin Hydrochloride Hydrochloride, Metformin Metformin HCl HCl, Metformin

Below are MeSH descriptors whose meaning is more general than "Metformin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amidines [D02.078]
Guanidines [D02.078.370]
Biguanides [D02.078.370.141]
Metformin [D02.078.370.141.450]

Below are MeSH descriptors whose meaning is related to "Metformin".

Below are MeSH descriptors whose meaning is more specific than "Metformin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Metformin" by people in this website by year, and whether "Metformin" was a major or minor topic of these publications.

Bar chart showing 52 publications over 19 distinct years, with a maximum of 5 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	2	1	3
2006	1	0	1
2008	1	1	2
2010	1	0	1
2011	2	1	3
2012	1	1	2
2013	2	1	3
2014	1	1	2
2015	3	0	3
2016	2	2	4
2017	2	0	2
2018	2	0	2
2019	3	0	3
2020	3	1	4
2021	2	1	3
2022	5	0	5
2023	4	0	4
2024	1	1	2
2025	2	1	3

Below are the most recent publications written about "Metformin" by people in Profiles.

Tjaden AH, Braffett BH, Butera NM, Araneta MR, Carmichael O, Groessl EJ, Hazuda HP, Hoskin MA, Ibebuogu U, Magee MF, Mau M, Stich T, Soliman D, Wallia A, Temprosa M, Golden SH. Sociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). Diabetes Care. 2025 Oct 01; 48(10):1685-1694.

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Reed S, Taka E, Darling-Reed S, Soliman KFA. Neuroprotective Effects of Metformin Through the Modulation of Neuroinflammation and Oxidative Stress. Cells. 2025 Jul 11; 14(14).

View in: PubMed
Farahani A, Farahani A, Kashfi K, Ghasemi A. Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide. Med Gas Res. 2025 Dec 01; 15(4):507-519.

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Vaishnav MS, Kumari N, Srikanta S, Simha V, Krishnaswamy PR, Balaram P, Bhat N. Albumin Oxidation and Albumin Glycation Discordance During Type 2 Diabetes Therapy: Biological and Clinical Implications. Metab Syndr Relat Disord. 2024 Jun; 22(5):372-384.

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Carrillo BJP, Cope E, Gurel S, Traslosheros A, Kenny A, Michot-Duval O, Mody N, Delibegovic M, Philip S, Thies F, Blana D, Gabriel BM. Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial. J Physiol. 2024 Dec; 602(23):6491-6506.

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Duru OK, Mangione CM, Turk N, Chon J, Fu J, Cheng G, Cheng F, Moss A, Frosch D, Jeffers KS, Castellon-Lopez Y, Tseng CH, Maranon R, Norris KC, Moin T. The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial. Diabetes Care. 2023 12 01; 46(12):2218-2222.

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Corley MJ, Pang APS, Shikuma CM, Ndhlovu LC. Cell-type specific impact of metformin on monocyte epigenetic age reversal in virally suppressed older people living with HIV. Aging Cell. 2024 01; 23(1):e13926.

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Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.

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Rashid R, Tripathi R, Singh A, Sarkar S, Kawale A, Bader GN, Gupta S, Gupta RK, Jha RK. Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats. Phytother Res. 2023 Sep; 37(9):4018-4041.

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Madievsky R, Vu A, Cheng F, Chon J, Turk N, Krueger A, Krong J, Maranon R, Liu S, Han CS, Norris KC, Mangione C, Page J, Thomas S, Duru OK, Moin T. A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study). Contemp Clin Trials. 2023 01; 124:107007.

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