Metformin

"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

Descriptor ID	D008687
MeSH Number(s)	D02.078.370.141.450
Concept/Terms	Metformin Metformin Dimethylbiguanidine Dimethylguanylguanidine Glucophage Glucophage Metformin Hydrochloride Metformin Hydrochloride Hydrochloride, Metformin Metformin HCl HCl, Metformin

Below are MeSH descriptors whose meaning is more general than "Metformin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amidines [D02.078]
Guanidines [D02.078.370]
Biguanides [D02.078.370.141]
Metformin [D02.078.370.141.450]

Below are MeSH descriptors whose meaning is related to "Metformin".

Below are MeSH descriptors whose meaning is more specific than "Metformin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Metformin" by people in this website by year, and whether "Metformin" was a major or minor topic of these publications.

Bar chart showing 46 publications over 18 distinct years, with a maximum of 5 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	2	1	3
2006	1	0	1
2008	1	1	2
2010	1	0	1
2011	2	1	3
2012	1	1	2
2013	2	1	3
2014	1	1	2
2015	3	0	3
2016	2	2	4
2017	1	0	1
2018	3	0	3
2019	1	0	1
2020	3	1	4
2021	2	1	3
2022	5	0	5
2023	4	0	4
2024	0	1	1

Below are the most recent publications written about "Metformin" by people in Profiles.

Vaishnav MS, Kumari N, Srikanta S, Simha V, Krishnaswamy PR, Balaram P, Bhat N. Albumin Oxidation and Albumin Glycation Discordance During Type 2 Diabetes Therapy: Biological and Clinical Implications. Metab Syndr Relat Disord. 2024 Jun; 22(5):372-384.

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Duru OK, Mangione CM, Turk N, Chon J, Fu J, Cheng G, Cheng F, Moss A, Frosch D, Jeffers KS, Castellon-Lopez Y, Tseng CH, Maranon R, Norris KC, Moin T. The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial. Diabetes Care. 2023 Dec 01; 46(12):2218-2222.

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Corley MJ, Pang APS, Shikuma CM, Ndhlovu LC. Cell-type specific impact of metformin on monocyte epigenetic age reversal in virally suppressed older people living with HIV. Aging Cell. 2024 01; 23(1):e13926.

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Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.

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Rashid R, Tripathi R, Singh A, Sarkar S, Kawale A, Bader GN, Gupta S, Gupta RK, Jha RK. Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats. Phytother Res. 2023 Sep; 37(9):4018-4041.

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Madievsky R, Vu A, Cheng F, Chon J, Turk N, Krueger A, Krong J, Maranon R, Liu S, Han CS, Norris KC, Mangione C, Page J, Thomas S, Duru OK, Moin T. A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study). Contemp Clin Trials. 2023 01; 124:107007.

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Deng Y, Polley EC, Wallach JD, Dhruva SS, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Lyon TD, Shah ND, Ross JS, McCoy RG. Emulating the GRADE trial using real world data: retrospective comparative effectiveness study. BMJ. 2022 10 03; 379:e070717.

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Olokpa E, Mandape SN, Pratap S, Stewart MV. Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells. BMC Cancer. 2022 Sep 29; 22(1):1025.

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Gant DMA, Parris AB, Yang X. Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells. Biochem Biophys Res Commun. 2022 07 12; 613:100-106.

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Hao Q, Huang Z, Li Q, Liu D, Wang P, Wang K, Li J, Cao W, Deng W, Wu K, Su R, Liu Z, Vadgama J, Wu Y. A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer. Adv Sci (Weinh). 2022 02; 9(6):e2102303.

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