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Lishomwa Ndhlovu, MD PhD

Title
Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Other Positions
    TitleSenior Investigator
    InstitutionUniversity of Hawaii
    DepartmentDepartment of Medicine


    Collapse Overview 
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    Our research is dedicated to understanding how HIV affects the immune system and how this will inform on strategies to prevent, slow or eliminate HIV infection and optimize quality of life outcomes.

    Collapse Research 
    Collapse research activities and funding
    R56AI083112     (NDHLOVU, LISHOMWA C.)Sep 17, 2010 - Aug 31, 2012
    NIH
    Modulating Tim-3 to control HIV infection
    Role: Principal Investigator
    R01MH104141     (NDHLOVU, LISHOMWA C)Jun 1, 2014 - Mar 31, 2020
    NIH
    Monocytes and HIV CNS Reservoirs in Super Acute HIV Infection
    Role: Principal Investigator
    R21AI122393     (NDHLOVU, LISHOMWA C)Aug 16, 2016 - Jul 31, 2018
    NIH
    Reversal of Adaptive Immune Dysfunction in Shock and Kill HIV Cure Strategies
    Role: Principal Investigator
    R01MH112457     (PILLAI, SATISH KUMAR)Sep 22, 2016 - Jun 30, 2021
    NIH
    Effects of Human Galectin-9 on the CNS HIV Reservoir
    Role: Co-Principal Investigator
    R21NS106970     (ABDEL MOHSEN, MOHAMED)Sep 20, 2017 - Aug 31, 2020
    NIH
    Exploring Cell-free Glycomic Interactions in HIV-associated Neurological Disorders
    Role: Co-Principal Investigator
    K12HL143960     (SHIKUMA, CECILIA M.)Aug 1, 2018 - Jun 30, 2023
    NIH
    Hawaii Interdisciplinary Mentored Career Development in HIV Co-Morbidities
    Role: Co-Principal Investigator
    R01AI142662     (SCANGA, CHARLES A.)Mar 4, 2019 - Feb 29, 2024
    NIH
    Effects of HIV SIV on unconventional T cells in immunity to M. tuberculosis in pre adolescents
    Role: Co-Principal Investigator
    R01AG063846     (NDHLOVU, LISHOMWA C)Mar 15, 2020 - Feb 28, 2025
    NIH
    Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction
    Role: Principal Investigator
    R01NS117458     (ABDEL MOHSEN, MOHAMED)May 1, 2020 - Mar 31, 2024
    NIH
    Host Glycomic Modulation of HIV-associated Neuro-inflammation During Viral Suppression
    Role: Co-Principal Investigator
    R01DA052027     (NIXON, DOUGLAS F)Jul 15, 2020 - Apr 30, 2025
    NIH
    Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuse and Aging on Cognitive Impairment
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ndhlovu LC, Bendall ML, Dwaraka V, Pang APS, Dopkins N, Carreras N, Smith R, Nixon DF, Corley MJ. Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements. Aging Cell. 2024 Aug 02; e14288. PMID: 39092674.
      Citations:    Fields:    
    2. Mori LP, Corley MJ, McAuley AT, Pang A, Venables T, Ndhlovu LC, Pipkin ME, Valente ST. Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1-infected CD4+ T cells. Life Sci Alliance. 2024 Oct; 7(10). PMID: 39089880.
      Citations:    Fields:    Translation:HumansCells
    3. Larson EC, Ellis AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, de Menezes YT, Ameel CL, Fillmore DJ, Pergalske SM, Juno JA, Maiello P, Chishti HB, Lin PL, Godfrey DI, Kent SJ, Pellicci DG, Ndhlovu LC, O'Connor SL, Scanga CA. Transiently boosting V?9+Vd2+ ?d T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance. bioRxiv. 2024 Jul 23. PMID: 39091843.
      Citations:    
    4. Mitchell BI, Yazel Eiser IE, Kallianpur KJ, Gangcuangco LM, Chow DC, Ndhlovu LC, Paul R, Shikuma CM. Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection. J Neurovirol. 2024 Jun 29. PMID: 38949728.
      Citations:    Fields:    
    5. Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. The single-cell opioid responses in the context of HIV (SCORCH) consortium. Mol Psychiatry. 2024 Jun 15. PMID: 38879719.
      Citations: 1     Fields:    
    6. Webb GM, Pessoa CT, McCullen AJ, Hwang JM, Humkey MC, Thormin-Odum R, Kukula KA, Smedley J, Fischer M, Sciurba J, Bochart RM, Shriver-Munsch C, Ndhlovu LC, Sacha JB. Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection. J Virol. 2024 Jun 13; 98(6):e0027324. PMID: 38775481.
      Citations:    Fields:    Translation:AnimalsCells
    7. Premeaux TA, Bowler S, Friday CM, Moser CB, Hoenigl M, Lederman MM, Landay AL, Gianella S, Ndhlovu LC. Machine learning models based on fluid immunoproteins that predict non-AIDS adverse events in people with HIV. iScience. 2024 Jun 21; 27(6):109945. PMID: 38812553.
      Citations:    
    8. Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR, Ndhlovu LC, Gan L, Greene WC. Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids. PNAS Nexus. 2024 May; 3(5):pgae179. PMID: 38737767.
      Citations:    
    9. Moar P, Linn K, Premeaux TA, Bowler S, Sardarni UK, Gopalan BP, Shwe EE, San T, Han H, Clements D, Hlaing CS, Kyu EH, Thair C, Mar YY, Nway N, Mannarino J, Bolzenius J, Mar S, Aye AMM, Tandon R, Paul R, Ndhlovu LC. Plasma galectin-9 relates to cognitive performance and inflammation among adolescents with vertically acquired HIV. AIDS. 2024 Aug 01; 38(10):1460-1467. PMID: 38608008.
      Citations:    Fields:    Translation:HumansPHPublic Health
    10. Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcaRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Apr 25. PMID: 38677592.
      Citations:    Fields:    
    11. Marques de Menezes EG, Bowler SA, Shikuma CM, Ndhlovu LC, Norris PJ. Circulating plasma-derived extracellular vesicles expressing bone and kidney markers are associated with neurocognitive impairment in people living with HIV. Front Neurol. 2024; 15:1383227. PMID: 38725641.
      Citations:    
    12. Joglekar A, Hu W, Zhang B, Narykov O, Diekhans M, Marrocco J, Balacco J, Ndhlovu LC, Milner TA, Fedrigo O, Jarvis ED, Sheynkman G, Korkin D, Ross ME, Tilgner HU. Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain. Nat Neurosci. 2024 Jun; 27(6):1051-1063. PMID: 38594596.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Hu W, Foord C, Hsu J, Fan L, Corley MJ, Bhatia TN, Xu S, Belchikov N, He Y, Pang AP, Lanjewar SN, Jarroux J, Joglekar A, Milner TA, Ndhlovu LC, Zhang J, Butelman E, Sloan SA, Lee VM, Gan L, Tilgner HU. ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease. bioRxiv. 2024 Feb 28. PMID: 38464236.
      Citations:    
    14. Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024 02 22; 16(4):3088-3106. PMID: 38393697.
      Citations: 2     Fields:    Translation:HumansCells
    15. Ndhlovu LC, Bendall ML, Dwaraka V, Pang AP, Dopkins N, Carreras N, Smith R, Nixon DF, Corley MJ. Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states. bioRxiv. 2023 Dec 07. PMID: 38106164.
      Citations:    
    16. Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M. HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 2023 10 28; 15(11). PMID: 38005849.
      Citations: 1     Fields:    Translation:HumansCells
    17. Moar P, Premeaux TA, Atkins A, Ndhlovu LC. The latent HIV reservoir: current advances in genetic sequencing approaches. mBio. 2023 Oct 31; 14(5):e0134423. PMID: 37811964.
      Citations: 1     Fields:    Translation:HumansCells
    18. Nana BC, Esemu LF, Besong ME, Atchombat DHN, Ogai K, Sobgui TMP, Nana CMM, Seumko'o RMN, Awanakan H, Ekali GL, Leke RGF, Okamoto S, Ndhlovu LC, Megnekou R. Soluble biomarkers of HIV-1-related systemic immune activation are associated with high plasma levels of growth factors implicated in the pathogenesis of Kaposi sarcoma in adults. Front Immunol. 2023; 14:1216480. PMID: 37809059.
      Citations:    Fields:    Translation:HumansCells
    19. Corley MJ, Pang APS, Shikuma CM, Ndhlovu LC. Cell-type specific impact of metformin on monocyte epigenetic age reversal in virally suppressed older people living with HIV. Aging Cell. 2024 01; 23(1):e13926. PMID: 37675817.
      Citations: 3     Fields:    Translation:HumansCells
    20. Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629. PMID: 37669308.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Promsote W, Chumpolkulwong K, Musich T, Corley MJ, Ndhlovu LC, Sopanaporn J, Inthawong D, Nadee P, Silsorn D, Sirisrisopa S, Wongsawanonkul S, Parsons MS, Cowden J, Imerbsin R, Lugo-Roman L, Vasan S, Hsu DC. Impact of sleep deprivation on neurocognition and inflammation in rhesus macaques. Brain Behav Immun Health. 2023 Nov; 33:100683. PMID: 37701789.
      Citations:    
    22. Chen X, Wang Y, Cappuccio A, Cheng WS, Zamojski FR, Nair VD, Miller CM, Rubenstein AB, Nudelman G, Tadych A, Theesfeld CL, Vornholt A, George MC, Ruffin F, Dagher M, Chawla DG, Soares-Schanoski A, Spurbeck RR, Ndhlovu LC, Sebra R, Kleinstein SH, Letizia AG, Ramos I, Fowler VG, Woods CW, Zaslavsky E, Troyanskaya OG, Sealfon SC. Author Correction: Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data. Nat Comput Sci. 2023 Sep; 3(9):805. PMID: 38177788.
      Citations:    Fields:    
    23. Schuetz A, Corley MJ, Sacdalan C, Phuang-Ngern Y, Nakpor T, Wansom T, Ehrenberg PK, Sriplienchan S, Thomas R, Ratnaratorn N, Sukhumvittaya S, Tragonlugsana N, Slike BM, Akapirat S, Pinyakorn S, Rerknimitr R, Pang AP, Kroon E, Teeratakulpisan N, Krebs SJ, Phanuphak N, Ndhlovu LC, Vasan S. Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition. JCI Insight. 2023 08 22; 8(16). PMID: 37432754.
      Citations:    Fields:    Translation:Humans
    24. Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani ZY, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells. J Mol Cell Biol. 2023 08 03; 15(4). PMID: 37127426.
      Citations: 4     Fields:    Translation:HumansCells
    25. Chen X, Wang Y, Cappuccio A, Cheng WS, Zamojski FR, Nair VD, Miller CM, Rubenstein AB, Nudelman G, Tadych A, Theesfeld CL, Vornholt A, George MC, Ruffin F, Dagher M, Chawla DG, Soares-Schanoski A, Spurbeck RR, Ndhlovu LC, Sebra R, Kleinstein SH, Letizia AG, Ramos I, Fowler VG, Woods CW, Zaslavsky E, Troyanskaya OG, Sealfon SC. Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data. Nat Comput Sci. 2023 Jul; 3(7):644-657. PMID: 37974651.
      Citations:    Fields:    
    26. Joseph J, Premeaux TA, Pinto DO, Rao A, Guha S, Panfil AR, Carey AJ, Ndhlovu LC, Bergmann-Leitner ES, Jain P. Retroviral b-Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation. J Extracell Biol. 2023 Jul; 2(7). PMID: 37547182.
      Citations:    
    27. Shikuma CM, Wojna V, De Gruttola V, Siriwardhana C, Souza SA, Rodriguez-Benitez RJ, Turner EH, Kallianpur K, Bolzenius J, Chow D, Matos M, Shiramizu B, Clements DM, Premeaux TA, Ndhlovu LC, Paul R. Impact of antiretroviral therapy intensification with C-C motif chemokine receptor 5 antagonist maraviroc on HIV-associated neurocognitive impairment. AIDS. 2023 11 01; 37(13):1987-1995. PMID: 37418541.
      Citations: 1     Fields:    Translation:Humans
    28. Premeaux TA, Ndhlovu LC. Decrypting biological hallmarks of aging in people with HIV. Curr Opin HIV AIDS. 2023 09 01; 18(5):237-245. PMID: 37421383.
      Citations:    Fields:    Translation:Humans
    29. Kroll KW, Woolley G, Terry K, Premeaux TA, Shikuma CM, Corley MJ, Bowler S, Ndhlovu LC, Reeves RK. Multiplex Analysis of Cytokines and Chemokines in Persons Aging With or Without HIV. AIDS Res Hum Retroviruses. 2023 07; 39(7):367-380. PMID: 37097212.
      Citations:    Fields:    Translation:Humans
    30. Premeaux TA, Yeung ST, Pillai SK, Ndhlovu LC. Elevated Galectin-9 across the human brain correlates with HIV neuropathology and detrimental cognitive states. J Neurovirol. 2023 06; 29(3):337-345. PMID: 37233903.
      Citations: 1     Fields:    Translation:Humans
    31. Larson EC, Ellis AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Menezes YK, Ameel CL, Fillmore DJ, Pergalske SM, Juno JA, Maiello P, White AG, Borish HJ, Godfrey DI, Kent SJ, Ndhlovu LC, O'Connor SL, Scanga CA. Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Na?ve Juvenile Macaques. Infect Immun. 2023 05 16; 91(5):e0055822. PMID: 37039653.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    32. Joglekar A, Hu W, Zhang B, Narykov O, Diekhans M, Balacco J, Ndhlovu LC, Milner TA, Fedrigo O, Jarvis ED, Sheynkman G, Korkin D, Ross ME, Tilgner HU. Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development. bioRxiv. 2023 Apr 04. PMID: 37066387.
      Citations:    
    33. Johnston CD, de Menezes EGM, Bowler S, Siegler EL, Friday C, Norris PJ, Rice MC, Choi ME, Glesby MJ, Ndhlovu LC. Correction to: Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV. J Neurovirol. 2023 Apr; 29(2):225. PMID: 37005979.
      Citations:    Fields:    
    34. Homan EA, Devereux RB, Tak KA, Mitlak HW, Volodarskiy A, Ramasubbu K, Zhang DT, Kushman A, Pollie MP, Agoglia HK, Tafreshi R, Goyal P, Shaw L, Ndhlovu L, RoyChoudhury A, Horn E, Narula N, Safford MM, Weinsaft JW, Kim J. Impact of acute TTE-evidenced cardiac dysfunction on in-hospital and outpatient mortality: A multicenter NYC COVID-19 registry study. PLoS One. 2023; 18(3):e0283708. PMID: 36972280.
      Citations: 1     Fields:    Translation:Humans
    35. Cheng D, Luo Z, Fitting S, Stoops W, Heath SL, Ndhlovu LC, Jiang W. The link between chronic cocaine use, B cell perturbations, and blunted immune recovery in HIV-infected individuals on suppressive ART. NeuroImmune Pharm Ther. 2023 03 25; 2(1):71-79. PMID: 37027536.
      Citations:    
    36. Johnston CD, de Menezes EGM, Bowler S, Siegler EL, Friday C, Norris PJ, Rice MC, Choi ME, Glesby MJ, Ndhlovu LC. Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV. J Neurovirol. 2023 04; 29(2):218-224. PMID: 36934200.
      Citations: 1     Fields:    Translation:HumansCells
    37. Joseph SB, Gianella S, Burdo TH, Cinque P, Gisslen M, Letendre S, Nath A, Morgello S, Ndhlovu LC, Spudich S. Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology. J Infect Dis. 2023 03 17; 227(Suppl 1):S3-S15. PMID: 36930640.
      Citations: 5     Fields:    Translation:HumansCells
    38. Chow DC, Saiki KMW, Siriwardhana C, Lozano-Gerona J, Vanapruks S, Ogle J, Premeaux TA, Ndhlovu LC, Boisvert WA. Increased transmigration of intermediate monocytes associated with atherosclerotic burden in people with HIV on antiretroviral therapy. AIDS. 2023 06 01; 37(7):1177-1179. PMID: 36927653.
      Citations: 1     Fields:    Translation:HumansCells
    39. Santamaria-Garcia H, Moguilner S, Rodriguez-Villagra OA, Botero-Rodriguez F, Pina-Escudero SD, O'Donovan G, Albala C, Matallana D, Schulte M, Slachevsky A, Yokoyama JS, Possin K, Ndhlovu LC, Al-Rousan T, Corley MJ, Kosik KS, Muniz-Terrera G, Miranda JJ, Ibanez A. The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations. Geroscience. 2023 08; 45(4):2405-2423. PMID: 36849677.
      Citations: 4     Fields:    Translation:Humans
    40. Kroll KW, Woolley G, Terry K, Premeaux TA, Shikuma CM, Corley MJ, Bowler S, Ndhlovu LC, Reeves RK. Multiplex analysis of cytokines and chemokines in persons aging with or without HIV. bioRxiv. 2023 Feb 02. PMID: 36778301.
      Citations:    
    41. Bolzenius J, Sacdalan C, Ndhlovu LC, Sailasuta N, Trautmann L, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Phanuphak N, Chan P, Premeaux T, Kroon E, Vasan S, Hsu DC, Valcour V, Ananworanich J, Robb ML, Ake JA, Pohl KM, Sriplienchan S, Spudich S, Paul R. Brain volumetrics differ by Fiebig stage in acute HIV infection. AIDS. 2023 05 01; 37(6):861-869. PMID: 36723491.
      Citations: 2     Fields:    Translation:HumansCells
    42. de Menezes EGM, Liu JS, Bowler SA, Giron LB, D'Antoni ML, Shikuma CM, Abdel-Mohsen M, Ndhlovu LC, Norris PJ. Circulating brain-derived extracellular vesicles expressing neuroinflammatory markers are associated with HIV-related neurocognitive impairment. Front Immunol. 2022; 13:1033712. PMID: 36601110.
      Citations: 3     Fields:    Translation:HumansCells
    43. Yuan Z, Giron LB, Hart C, Gyampoh A, Koshy J, Hong KY, Niki T, Premeaux TA, Ndhlovu LC, Deleage C, Montaner LJ, Abdel-Mohsen M. Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice. AIDS. 2023 03 15; 37(4):571-577. PMID: 36460646.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    44. Dean LS, Chow DC, Ndhlovu LC, Boisvert WA, Chang SP, Shikuma CM, Park J. Characterization of Circulating Fibrocytes in People Living with HIV on Stable Antiretroviral Therapy. Immunohorizons. 2022 11 01; 6(11):760-767. PMID: 36445359.
      Citations: 1     Fields:    Translation:Humans
    45. Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC. Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons. mBio. 2022 12 20; 13(6):e0230822. PMID: 36314791.
      Citations: 30     Fields:    Translation:HumansCells
    46. Bowler S, Papoutsoglou G, Karanikas A, Tsamardinos I, Corley MJ, Ndhlovu LC. A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severity. Sci Rep. 2022 10 19; 12(1):17480. PMID: 36261477.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    47. Yeung ST, Premeaux TA, Du L, Niki T, Pillai SK, Khanna KM, Ndhlovu LC. Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection. Front Immunol. 2022; 13:1011185. PMID: 36325323.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Kroll KW, Shah SV, Lucar OA, Premeaux TA, Shikuma CM, Corley MJ, Mosher M, Woolley G, Bowler S, Ndhlovu LC, Reeves RK. Mucosal-homing natural killer cells are associated with aging in persons living with HIV. Cell Rep Med. 2022 10 18; 3(10):100773. PMID: 36208628.
      Citations: 4     Fields:    Translation:HumansCells
    49. Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. JCI Insight. 2022 07 08; 7(13). PMID: 35801589.
      Citations: 9     Fields:    Translation:HumansCells
    50. Paul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S. Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection. Psychosom Med. 2022 10 01; 84(8):976-983. PMID: 36162059.
      Citations: 5     Fields:    Translation:HumansCells
    51. Pang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC, Corley MJ. Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Front Genet. 2022; 13:819749. PMID: 35719387.
      Citations:    
    52. Esemu LF, Awanakam H, Nanfa D, Besong M, Tsayem I, Nkenfou CN, Bigoga J, Leke R, Eugene S, Ndhlovu LC, Loni GE. Expression profiles of miR3181 and miR199a in plasma and placenta of virally suppressed HIV-1 infected Cameroonian pregnant women at delivery. PLoS One. 2022; 17(5):e0268820. PMID: 35594307.
      Citations: 1     Fields:    Translation:HumansCells
    53. Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani Z, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells. bioRxiv. 2022 May 16. PMID: 35378763.
      Citations:    
    54. Marques de Menezes EG, Deng X, Liu J, Bowler SA, Shikuma CM, Stone M, Hunt PW, Ndhlovu LC, Norris PJ. Plasma CD16+ Extracellular Vesicles Associate with Carotid Artery Intima-Media Thickness in HIV+ Adults on Combination Antiretroviral Therapy. mBio. 2022 06 28; 13(3):e0300521. PMID: 35435733.
      Citations: 5     Fields:    Translation:HumansCells
    55. Chang XL, Reed JS, Webb GM, Wu HL, Le J, Bateman KB, Greene JM, Pessoa C, Waytashek C, Weber WC, Hwang J, Fischer M, Moats C, Shiel O, Bochart RM, Crank H, Siess D, Giobbi T, Torgerson J, Agnor R, Gao L, Dhody K, Lalezari JP, Bandar IS, Carnate AM, Pang AS, Corley MJ, Kelly S, Pourhassan N, Smedley J, Bimber BN, Hansen SG, Ndhlovu LC, Sacha JB. Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species. PLoS Pathog. 2022 03; 18(3):e1010396. PMID: 35358290.
      Citations: 6     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    56. Nixon DF, Schwartz RE, Ndhlovu LC. Booster vaccines for COVID-19 vaccine breakthrough cases? Lancet. 2022 03 26; 399(10331):1224. PMID: 35339219.
      Citations:    Fields:    Translation:Humans
    57. Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MM, Koopmans F, Prjibelski AD, Mikheenko A, Belchikov N, Jarroux J, Lucas AB, Palkovits M, Luo W, Milner TA, Ndhlovu LC, Smit AB, Trojanowski JQ, Lee VMY, Fedrigo O, Sloan SA, Tomb?cz D, Ross ME, Jarvis E, Boldogkoi Z, Gan L, Tilgner HU. Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nat Biotechnol. 2022 07; 40(7):1082-1092. PMID: 35256815.
      Citations: 32     Fields:    Translation:HumansCells
    58. Premeaux TA, Yeung ST, Bukhari Z, Bowler S, Alpan O, Gupta R, Ndhlovu LC. Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies. Front Immunol. 2022; 13:842740. PMID: 35265086.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    59. Hsu DC, Chumpolkulwong K, Corley MJ, Hunsawong T, Inthawong D, Schuetz A, Imerbsin R, Silsorn D, Nadee P, Sopanaporn J, Phuang-Ngern Y, Klungthong C, Reed M, Fernandez S, Ndhlovu LC, Paul R, Lugo-Roman L, Michael NL, Modjarrad K, Vasan S. Neurocognitive impact of Zika virus infection in adult rhesus macaques. J Neuroinflammation. 2022 Feb 07; 19(1):40. PMID: 35130924.
      Citations: 6     Fields:    Translation:AnimalsCells
    60. Reeves RK, Ndhlovu L. Call for Papers: AIDS Research and Human Retroviruses. AIDS Res Hum Retroviruses. 2022 02; 38(2):75. PMID: 35076291.
      Citations:    Fields:    
    61. Premeaux TA, Moser CB, McKhann A, Hoenigl M, Yeung ST, Pang APS, Corley MJ, Lederman MM, Landay AL, Gianella S, Ndhlovu LC. Monitoring Circulating Immune Checkpoint Proteins as Predictors of Non-AIDS Morbid Events in People With HIV Initiating Antiretroviral Therapy. Open Forum Infect Dis. 2022 Mar; 9(3):ofab570. PMID: 35146038.
      Citations:    
    62. Apple AC, Oddi A, Peluso MJ, Asken BM, Henrich TJ, Kelly JD, Pleasure SJ, Deeks SG, Allen IE, Martin JN, Ndhlovu LC, Miller BL, Stephens ML, Hellmuth J. Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19. Ann Clin Transl Neurol. 2022 02; 9(2):221-226. PMID: 35043593.
      Citations: 29     Fields:    Translation:HumansCells
    63. Shikuma CM, Le T, Phuong TV, Chew GM, Nguyen VVC, Vo TL, Siriwardhana C, Chow D, Ghukasyan H, Limpruttidham N, Premeaux T, Gangcuangco LM, Paul R, Ndhlovu LC. Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam. AIDS Res Hum Retroviruses. 2022 06; 38(6):441-450. PMID: 34861767.
      Citations:    Fields:    Translation:HumansCells
    64. Cheng D, Luo Z, Fu X, Stephenson S, Di Germanio C, Norris PJ, Fuchs D, Ndhlovu LC, Li QZ, Zetterberg H, Gisslen M, Price RW, Peng S, Jiang W. Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation. Microbiol Spectr. 2022 02 23; 10(1):e0197521. PMID: 34985329.
      Citations: 2     Fields:    Translation:Humans
    65. Reeves RK, Ndhlovu L. Call for Papers: AIDS Research and Human Retroviruses. AIDS Res Hum Retroviruses. 2022 01; 38(1):1. PMID: 34936497.
      Citations:    Fields:    
    66. Premeaux TA, Moser CB, McKhann A, Hoenigl M, Laws EI, Aquino DL, Lederman MM, Landay AL, Gianella S, Ndhlovu LC. Plasma galectin-9 as a predictor of adverse non-AIDS events in persons with chronic HIV during suppressive antiretroviral therapy. AIDS. 2021 12 01; 35(15):2489-2495. PMID: 34366381.
      Citations: 4     Fields:    Translation:Humans
    67. Corley MJ, Pang APS, Rasmussen TA, Tolstrup M, S?gaard OS, Ndhlovu LC. Candidate host epigenetic marks predictive for HIV reservoir size, responsiveness to latency reversal, and viral rebound. AIDS. 2021 11 15; 35(14):2269-2279. PMID: 34482353.
      Citations: 1     Fields:    Translation:HumansCells
    68. Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. PLoS Pathog. 2021 11; 17(11):e1010034. PMID: 34762717.
      Citations: 8     Fields:    Translation:HumansCells
    69. Corley MJ, Sacdalan C, Pang APS, Chomchey N, Ratnaratorn N, Valcour V, Kroon E, Cho KS, Belden AC, Colby D, Robb M, Hsu D, Spudich S, Paul R, Vasan S, Ndhlovu LC. Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART. PLoS Pathog. 2021 08; 17(8):e1009785. PMID: 34388205.
      Citations: 5     Fields:    Translation:HumansCells
    70. Shytaj IL, Procopio FA, Tarek M, Carlon-Andres I, Tang HY, Goldman AR, Munshi M, Kumar Pal V, Forcato M, Sreeram S, Leskov K, Ye F, Lucic B, Cruz N, Ndhlovu LC, Bicciato S, Padilla-Parra S, Diaz RS, Singh A, Lusic M, Karn J, Alvarez-Carbonell D, Savarino A. Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress. EMBO Mol Med. 2021 08 09; 13(8):e13901. PMID: 34289240.
      Citations: 20     Fields:    Translation:HumansCells
    71. Premeaux TA, Mediouni S, Leda A, Furler RL, Valente ST, Fine HA, Nixon DF, Ndhlovu LC. Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research. mBio. 2021 08 31; 12(4):e0068021. PMID: 34253056.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    72. Chang XL, Webb GM, Wu HL, Greene JM, Abdulhaqq S, Bateman KB, Reed JS, Pessoa C, Weber WC, Maier N, Chew GM, Gilbride RM, Gao L, Agnor R, Giobbi T, Torgerson J, Siess D, Burnett N, Fischer M, Shiel O, Moats C, Patterson B, Dhody K, Kelly S, Pourhassan N, Magnani DM, Smedley J, Bimber BN, Haigwood NL, Hansen SG, Brown TR, Ndhlovu LC, Sacha JB. Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission. Nat Commun. 2021 06 07; 12(1):3343. PMID: 34099693.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    73. Nixon DF, Ndhlovu LC. Vaccine Breakthrough Infections with SARS-CoV-2 Variants. N Engl J Med. 2021 07 08; 385(2):e7. PMID: 34077640.
      Citations: 12     Fields:    Translation:HumansCells
    74. Plassmeyer M, Alpan O, Corley MJ, Premeaux TA, Lillard K, Coatney P, Vaziri T, Michalsky S, Pang APS, Bukhari Z, Yeung ST, Evering TH, Naughton G, Latterich M, Mudd P, Spada A, Rindone N, Loizou D, Ulrik S?nder S, Ndhlovu LC, Gupta R. Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS-CoV-2 infection and long COVID. Allergy. 2022 01; 77(1):118-129. PMID: 33993490.
      Citations: 35     Fields:    Translation:HumansCells
    75. Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM. Correction: Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation. PLoS One. 2021; 16(3):e0249428. PMID: 33765089.
      Citations: 1     Fields:    
    76. Paul RH, Shikuma CM, Chau NVV, Ndhlovu LC, Thanh NT, Belden AC, Chow DC, Chew GM, Premeaux TA, Ly VT, McBride JAD, Bolzenius JD, Le T. Neurocognitive Trajectories After 72 Weeks of First-Line Anti-retroviral Therapy in Vietnamese Adults With HIV-HCV Co-infection. Front Neurol. 2021; 12:602263. PMID: 33776879.
      Citations:    
    77. Bowler S, Mitchell BI, Kallianpur KJ, Chow D, Jiang W, Shikuma CM, Ndhlovu LC. Plasma anti-CD4 IgG is associated with brain abnormalities in people with HIV on antiretroviral therapy. J Neurovirol. 2021 04; 27(2):334-339. PMID: 33710596.
      Citations: 3     Fields:    Translation:HumansCells
    78. Clements DM, Crumley B, Chew GM, Davis E, Bruhn R, Murphy EL, Ndhlovu LC, Jain P. Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection. Front Immunol. 2021; 12:608890. PMID: 33767694.
      Citations: 5     Fields:    Translation:HumansCells
    79. Corley MJ, Pang APS, Dody K, Mudd PA, Patterson BK, Seethamraju H, Bram Y, Peluso MJ, Torres L, Iyer NS, Premeaux TA, Yeung ST, Chandar V, Borczuk A, Schwartz RE, Henrich TJ, Deeks SG, Sacha JB, Ndhlovu LC. Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19. J Leukoc Biol. 2021 07; 110(1):21-26. PMID: 33464637.
      Citations: 55     Fields:    Translation:HumansCells
    80. Baumer Y, Weatherby TM, Mitchell BI, SahBandar IN, Premeaux TA, Michelle L D, Gutierrez-Huerta CA, Powell-Wiley TM, Brown TR, Boisvert WA, Shikuma CM, Ndhlovu LC. Hiding in plain sight - platelets, the silent carriers of HIV-1. Platelets. 2021 Nov 17; 32(8):1038-1042. PMID: 33222575.
      Citations: 2     Fields:    Translation:HumansCells
    81. Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB. CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14. Int J Infect Dis. 2021 Feb; 103:25-32. PMID: 33186704.
      Citations: 72     Fields:    Translation:HumansCells
    82. Chew GM, Padua AJP, Chow DC, Souza SA, Clements DM, Corley MJ, Pang APS, Alejandria MM, Gerschenson M, Shikuma CM, Ndhlovu LC. Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T Cell Responses to PD-L1 Blockade. AIDS Res Hum Retroviruses. 2021 01; 37(1):24-33. PMID: 33019813.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    83. Kim J, Volodarskiy A, Sultana R, Pollie MP, Yum B, Nambiar L, Tafreshi R, Mitlak HW, RoyChoudhury A, Horn EM, Hriljac I, Narula N, Kim S, Ndhlovu L, Goyal P, Safford MM, Shaw L, Devereux RB, Weinsaft JW. Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19. J Am Coll Cardiol. 2020 10 27; 76(17):1965-1977. PMID: 33092732.
      Citations: 66     Fields:    Translation:HumansCellsPHPublic Health
    84. Mitchell BI, Laws EI, Chow DC, SahBandar IN, Gangcuangco LMA, Shikuma CM, Ndhlovu LC. Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy. Viruses. 2020 10 05; 12(10). PMID: 33028018.
      Citations: 1     Fields:    Translation:HumansCells
    85. Chow DC, Mau M, Hodis HN, Kewcharoen J, Li Y, Siriwardhana C, Souza SA, Mitchell BI, Bowler S, SahBandar I, Gangcuangco LMA, MacPherson I, Ndhlovu LC, Shikuma CM. Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes. AIDS Res Hum Retroviruses. 2020 12; 36(12):1020-1023. PMID: 32862657.
      Citations: 1     Fields:    Translation:HumansCells
    86. Su?rez-Fari?as M, Tokuyama M, Wei G, Huang R, Livanos A, Jha D, Levescot A, Irizar H, Kosoy R, Cording S, Wang W, Losic B, Ungaro RC, Di'Narzo A, Martinez-Delgado G, Suprun M, Corley MJ, Stojmirovic A, Houten SM, Peters L, Curran M, Brodmerkel C, Perrigoue J, Friedman JR, Hao K, Schadt EE, Zhu J, Ko HM, Cho J, Dubinsky MC, Sands BE, Ndhlovu L, Cerf-Bensusan N, Kasarskis A, Colombel JF, Harpaz N, Argmann C, Mehandru S. Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease. Gastroenterology. 2021 01; 160(1):287-301.e20. PMID: 32980345.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    87. Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T, Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N. GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity. FASEB J. 2020 11; 34(11):14820-14831. PMID: 32910505.
      Citations: 6     Fields:    Translation:AnimalsCells
    88. Kallianpur KJ, Birn R, Ndhlovu LC, Souza SA, Mitchell B, Paul R, Chow DC, Kohorn L, Shikuma CM. Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection. J Behav Brain Sci. 2020 Aug; 10(8):344-370. PMID: 32968547.
      Citations:    
    89. Chow DC, Bernas MA, Gangcuangco LM, Huynh J, Kohorn LB, Kallianpur KJ, Souza SA, Shiramizu B, Ndhlovu LC, Shikuma CM. Frailty Is Associated With Insulin Resistance in Chronic Human Immunodeficiency Virus Infection. Clin Infect Dis. 2020 08 14; 71(4):1127-1128. PMID: 31612202.
      Citations: 1     Fields:    Translation:HumansCells
    90. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS. 2020 08 01; 34(10):1451-1460. PMID: 32675558.
      Citations: 1     Fields:    Translation:HumansCells
    91. Premeaux TA, Javandel S, Hosaka KRJ, Greene M, Therrien N, Allen IE, Corley MJ, Valcour VG, Ndhlovu LC. Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. Front Immunol. 2020; 11:1321. PMID: 32695109.
      Citations: 10     Fields:    Translation:HumansCells
    92. Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari JP, Pang AP, Sugai C, Francisco EB, Pise A, Rodrigues H, Ryou M, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Aklin E, Ndhlovu L, Sacha JB. Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19. medRxiv. 2020 May 05. PMID: 32511656.
      Citations:    
    93. Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM. Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation. PLoS One. 2020; 15(4):e0231761. PMID: 32353005.
      Citations: 11     Fields:    Translation:HumansCells
    94. Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V. Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection. AIDS. 2020 03 01; 34(3):415-426. PMID: 31725432.
      Citations: 8     Fields:    Translation:Humans
    95. Chang K, Premeaux TA, Cobigo Y, Milanini B, Hellmuth J, Rubin LH, Javandel S, Allen I, Ndhlovu LC, Paul R, Valcour V. Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals. AIDS. 2020 02 01; 34(2):203-213. PMID: 31634200.
      Citations: 16     Fields:    Translation:Humans
    96. Shikuma CM, Chew GM, Kohorn L, Souza SA, Chow D, SahBandar IN, Park EY, Hanks N, Gangcuangco LMA, Gerschenson M, Ndhlovu LC. Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy. AIDS Res Hum Retroviruses. 2020 04; 36(4):303-305. PMID: 31731885.
      Citations: 17     Fields:    Translation:HumansCells
    97. D'Antoni ML, Kallianpur KJ, Premeaux TA, Corley MJ, Fujita T, Laws EI, Ogata-Arakaki D, Chow DC, Khadka VS, Shikuma CM, Ndhlovu LC. Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection. Front Immunol. 2019; 10:2789. PMID: 31849969.
      Citations: 1     Fields:    Translation:HumansCells
    98. SahBandar IN, Ndhlovu LC, Saiki K, Kohorn LB, Peterson MM, D'Antoni ML, Shiramizu B, Shikuma CM, Chow DC. Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness. J Atheroscler Thromb. 2020 May 01; 27(5):441-448. PMID: 31588100.
      Citations: 18     Fields:    Translation:HumansCells
    99. Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK. Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research. AIDS Res Hum Retroviruses. 2019 Nov-Dec; 35(11-12):999-1012. PMID: 31456412.
      Citations: 5     Fields:    Translation:Humans
    100. Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P. Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models. Front Oncol. 2019; 9:720. PMID: 31428586.
      Citations:    
    101. Limpruttidham N, Mitchell BI, Kallianpur KJ, Nakamoto BK, Souza SA, Shiramizu B, Ndhlovu LC, Chow DC, Shikuma CM. S100B and its association with HIV-associated neurocognitive disorders. J Neurovirol. 2019 12; 25(6):899-900. PMID: 31278533.
      Citations: 2     Fields:    Translation:Humans
    102. Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults. Clin Epigenetics. 2019 06 28; 11(1):95. PMID: 31253200.
      Citations: 9     Fields:    Translation:HumansCells
    103. Hosaka KRJ, Greene M, Premeaux TA, Javandel S, Allen IE, Ndhlovu LC, Valcour V. Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment. J Am Geriatr Soc. 2019 09; 67(9):1913-1916. PMID: 31241764.
      Citations: 18     Fields:    Translation:Humans
    104. Bowler S, Chew GM, Budoff M, Chow D, Mitchell BI, D'Antoni ML, Siriwardhana C, Ndhlovu LC, Shikuma C. PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults. J Acquir Immune Defic Syndr. 2019 05 01; 81(1):e21-e23. PMID: 30865177.
      Citations: 3     Fields:    Translation:HumansCells
    105. Esemu LF, Yuosembom EK, Fang R, Rasay S, Fodjo BAY, Nguasong JT, Kidima W, Ekali GL, Chen JJ, Ndhlovu L, Bigoga JD, Taylor DW, Leke RGF, Babakhanyan A. Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy. PLoS One. 2019; 14(5):e0215825. PMID: 31042729.
      Citations: 6     Fields:    Translation:Humans
    106. Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC. Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion. Oncoimmunology. 2019; 8(8):1601482. PMID: 31413910.
      Citations: 14     Fields:    
    107. Mitchell BI, Laws EI, Ndhlovu LC. Impact of Myeloid Reservoirs in HIV Cure Trials. Curr HIV/AIDS Rep. 2019 04; 16(2):129-140. PMID: 30835045.
      Citations: 18     Fields:    Translation:HumansCells
    108. Colomb F, Giron LB, Premeaux TA, Mitchell BI, Niki T, Papasavvas E, Montaner LJ, Ndhlovu LC, Abdel-Mohsen M. Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling. Front Immunol. 2019; 10:267. PMID: 30842775.
      Citations: 15     Fields:    Translation:HumansCells
    109. Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gissl?n M, Price RW, Valcour V, Ndhlovu LC. Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. J Neurovirol. 2019 04; 25(2):150-161. PMID: 30478799.
      Citations: 16     Fields:    Translation:HumansCells
    110. Zhang Z, Chew GM, Shikuma CM, Gangcuangco LMA, Souza SA, Shiramizu B, Nakamoto BK, Gong T, Mannem SR, Mitchell BI, Kallianpur KJ, Ndhlovu LC, Chow DC. Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults. HIV Clin Trials. 2018 10; 19(5):172-176. PMID: 30422099.
      Citations: 7     Fields:    Translation:HumansCells
    111. Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Anti-a4?7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. 2018 10 03; 10(461). PMID: 30282696.
      Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
    112. D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC. Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018 09 22; 218(9):1453-1463. PMID: 29868826.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    113. D'Antoni ML, Paul RH, Mitchell BI, Kohorn L, Fischer L, Lefebvre E, Seyedkazemi S, Nakamoto BK, Walker M, Kallianpur KJ, Ogata-Arakaki D, Ndhlovu LC, Shikuma C. Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism. J Acquir Immune Defic Syndr. 2018 09 01; 79(1):108-116. PMID: 29781885.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    114. D'Antoni ML, Mitchell BI, McCurdy S, Byron MM, Ogata-Arakaki D, Chow D, Mehta NN, Boisvert WA, Lefebvre E, Shikuma CM, Ndhlovu LC, Baumer Y. Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression. J Leukoc Biol. 2018 12; 104(6):1241-1252. PMID: 30088682.
      Citations: 9     Fields:    Translation:HumansCells
    115. McIntosh RC, Paul R, Ndhlovu LC, Hidalgo M, Lobo JD, Walker M, Shikuma CM, Kallianpur KJ. Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV. J Neurovirol. 2018 10; 24(5):616-628. PMID: 30022427.
      Citations: 11     Fields:    Translation:Humans
    116. Mulherkar R, Karabudak A, Ginwala R, Huang X, Rowan A, Philip R, Murphy EL, Clements D, Ndhlovu LC, Khan ZK, Jain P. In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection. Vaccine. 2018 08 09; 36(33):5046-5057. PMID: 30005946.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    117. Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S. Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques. J Virol. 2018 06 01; 92(11). PMID: 29563297.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    118. Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N. GITR cosignal in ILC2s controls allergic lung inflammation. J Allergy Clin Immunol. 2018 05; 141(5):1939-1943.e8. PMID: 29427641.
      Citations: 29     Fields:    Translation:AnimalsCells
    119. Hsu DC, Wegner MD, Sunyakumthorn P, Silsorn D, Tayamun S, Inthawong D, Kuncharin Y, Im-Erbsin R, Ege C, O'Connell RJ, Michael NL, Ndhlovu LC, Vasan S. CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection. J Med Primatol. 2017 08; 46(4):154-157. PMID: 28748665.
      Citations: 7     Fields:    Translation:AnimalsCells
    120. SahBandar IN, Samonte G, Telan E, Siripong N, Belcaid M, Schanzenbach D, Leano S, Chagan-Yasutan H, Hattori T, Shikuma CM, Ndhlovu LC. Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines. AIDS Res Hum Retroviruses. 2017 Nov; 33(11):1099-1106. PMID: 28569550.
      Citations: 6     Fields:    Translation:HumansCells
    121. Wirunsawanya K, Belyea L, Shikuma C, Watanabe RM, Kohorn L, Shiramizu B, Mitchell BI, Souza SA, Keating SM, Norris PJ, Ndhlovu LC, Chow D. Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection. AIDS Res Hum Retroviruses. 2017 07; 33(7):723-727. PMID: 28322572.
      Citations: 6     Fields:    Translation:Humans
    122. Ginwala R, Caruso B, Khan ZK, Pattekar A, Chew GM, Corley MJ, Loonawat R, Jacobson S, Sreedhar S, Ndhlovu LC, Jain P. HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-?c-/- (RAG1-Hu) and BLT Mice. J Neuroimmune Pharmacol. 2017 09; 12(3):504-520. PMID: 28374110.
      Citations: 11     Fields:    Translation:HumansAnimals
    123. Leal FE, Premeaux TA, Abdel-Mohsen M, Ndhlovu LC. Role of Natural Killer Cells in HIV-Associated Malignancies. Front Immunol. 2017; 8:315. PMID: 28377768.
      Citations: 4     Fields:    
    124. Gangcuangco LMA, Kohorn LB, Chow DC, Keating SM, Norris PJ, Nagamine LS, Ndhlovu LC, Souza SA, Kallianpur KJ, Shikuma CM. High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy. Medicine (Baltimore). 2016 Oct; 95(43):e5270. PMID: 27787390.
      Citations: 2     Fields:    Translation:Humans
    125. Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment. Sci Rep. 2016 09 15; 6:33310. PMID: 27629381.
      Citations: 28     Fields:    Translation:HumansCells
    126. Kallianpur KJ, Sakoda M, Gangcuangco LM, Ndhlovu LC, Umaki T, Chow D, Wongjittraporn S, Shikuma CM. Frailty Characteristics in Chronic HIV Patients are Markers of White Matter Atrophy Independently of Age and Depressive Symptoms: A Pilot Study. Open Med J. 2016; 3:138-152. PMID: 27721908.
      Citations:    
    127. Sacha JB, Ndhlovu LC. Strategies to target non-T-cell HIV reservoirs. Curr Opin HIV AIDS. 2016 07; 11(4):376-82. PMID: 27023285.
      Citations: 13     Fields:    Translation:HumansCells
    128. Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK. Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. PLoS Pathog. 2016 06; 12(6):e1005677. PMID: 27253379.
      Citations: 44     Fields:    Translation:HumansCells
    129. Riangwiwat T, Kohorn LB, Chow DC, Souza SA, Ndhlovu LC, Wong JW, Gangcuangco LM, Shikuma CM. CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population. J Acquir Immune Defic Syndr. 2016 May 01; 72(1):e17-9. PMID: 26885805.
      Citations: 2     Fields:    Translation:HumansCells
    130. Mitchell BI, Byron MM, Ng RC, Chow DC, Ndhlovu LC, Shikuma CM. Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-?1 in HIV-Infected Individuals on Stable Antiretroviral Therapy. PLoS One. 2016; 11(4):e0153758. PMID: 27097224.
      Citations: 4     Fields:    Translation:HumansCells
    131. Chow DC, Kagihara JM, Zhang G, Souza SA, Hodis HN, Li Y, Mitchell BI, Nakamoto BK, Kallianpur KJ, Keating SM, Norris PJ, Kohorn LB, Ndhlovu LC, Shikuma CM. Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy. HIV Clin Trials. 2016 05; 17(3):114-22. PMID: 27125366.
      Citations: 17     Fields:    Translation:HumansCells
    132. Kallianpur KJ, Gerschenson M, Mitchell BI, LiButti DE, Umaki TM, Ndhlovu LC, Nakamoto BK, Chow DC, Shikuma CM. Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients. Mitochondrion. 2016 05; 28:8-15. PMID: 26923169.
      Citations: 23     Fields:    Translation:HumansCells
    133. Chow D, Kohorn L, Souza S, Ndhlovu L, Ando A, Kallianpur KJ, Byron MM, Baumer Y, Keating S, Shikuma C. Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin. AIDS. 2016 Feb 20; 30(4):672-4. PMID: 26825035.
      Citations: 6     Fields:    Translation:Humans
    134. Zungsontiporn N, Tello RR, Zhang G, Mitchell BI, Budoff M, Kallianpur KJ, Nakamoto BK, Keating SM, Norris PJ, Ndhlovu LC, Souza SA, Shikuma CM, Chow DC. Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy. PLoS One. 2016; 11(2):e0149143. PMID: 26867220.
      Citations: 24     Fields:    Translation:HumansCells
    135. Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016 Jan; 12(1):e1005349. PMID: 26741490.
      Citations: 173     Fields:    Translation:HumansAnimalsCells
    136. Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS. The meningeal lymphatic system: a route for HIV brain migration? J Neurovirol. 2016 06; 22(3):275-81. PMID: 26572785.
      Citations: 24     Fields:    Translation:HumansCells
    137. Zungsontiporn N, Ndhlovu LC, Mitchell BI, Stein JH, Kallianpur KJ, Nakamoto B, Keating SM, Norris PJ, Souza SA, Shikuma CM, Chow DC. Serum amyloid P (SAP) is associated with impaired brachial artery flow-mediated dilation in chronically HIV-1 infected adults on stable antiretroviral therapy. HIV Clin Trials. 2015 11; 16(6):228-35. PMID: 26777795.
      Citations: 4     Fields:    Translation:HumansCells
    138. Ndhlovu LC, D'Antoni ML, Ananworanich J, Byron MM, Chalermchai T, Sithinamsuwan P, Tipsuk S, Ho E, Slike BM, Schuetz A, Zhang G, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Valcour V. Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-na?ve HIV-infected Thais. J Neuroimmunol. 2015 Nov 15; 288:25-33. PMID: 26531691.
      Citations: 16     Fields:    Translation:HumansCells
    139. Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J Virol. 2015 Apr; 89(7):3723-36. PMID: 25609823.
      Citations: 40     Fields:    Translation:HumansCells
    140. Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95. PMID: 26042612.
      Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
    141. Munger AM, Chow DC, Playford MP, Parikh NI, Gangcuangco LM, Nakamoto BK, Kallianpur KJ, Ndhlovu LC, Shikuma CM, Mehta NN. Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens. AIDS Res Hum Retroviruses. 2015 Feb; 31(2):221-8. PMID: 25416403.
      Citations: 10     Fields:    Translation:Humans
    142. O-charoen P, Ndhlovu LC, Gangcuangco LM, Keating SM, Norris PJ, Ng RC, Mitchell BI, Shikuma CM, Chow DC. Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy. AIDS Res Hum Retroviruses. 2014 Dec; 30(12):1185-91. PMID: 25205472.
      Citations: 3     Fields:    Translation:Humans
    143. Fujita T, Burwitz BJ, Chew GM, Reed JS, Pathak R, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, Ndhlovu LC. Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J Immunol. 2014 Dec 01; 193(11):5576-83. PMID: 25348621.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    144. Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM. Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND). J Neurovirol. 2014 Dec; 20(6):571-82. PMID: 25227930.
      Citations: 55     Fields:    Translation:HumansCells
    145. Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC. Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers. AIDS Res Hum Retroviruses. 2014 Jul; 30(7):654-64. PMID: 24786365.
      Citations: 45     Fields:    Translation:HumansCells
    146. Chagan-Yasutan H, Lacuesta TL, Ndhlovu LC, Oguma S, Leano PS, Telan EF, Kubo T, Morita K, Uede T, Dimaano EM, Hattori T. Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities. Thromb Res. 2014 Aug; 134(2):449-54. PMID: 24861695.
      Citations: 19     Fields:    Translation:HumansCells
    147. Lanteri MC, Diamond MS, Law JP, Chew GM, Wu S, Inglis HC, Wong D, Busch MP, Norris PJ, Ndhlovu LC. Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infection. PLoS One. 2014; 9(3):e92134. PMID: 24642562.
      Citations: 9     Fields:    Translation:HumansCells
    148. Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD. Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV. PLoS One. 2014; 9(2):e90330. PMID: 24587328.
      Citations: 26     Fields:    Translation:HumansCells
    149. Shikuma CM, Gangcuangco LM, Killebrew DA, Libutti DE, Chow DC, Nakamoto BK, Liang CY, Milne CI, Ndhlovu LC, Barbour JD, Shiramizu BT, Gerschenson M. The role of HIV and monocytes/macrophages in adipose tissue biology. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):151-9. PMID: 24091690.
      Citations: 27     Fields:    Translation:HumansCells
    150. Crawford TQ, Jalbert E, Ndhlovu LC, Barbour JD. Concomitant evaluation of PMA+ionomycin-induced kinase phosphorylation and cytokine production in T cell subsets by flow cytometry. Cytometry A. 2014 Mar; 85(3):268-76. PMID: 24464647.
      Citations: 12     Fields:    Translation:HumansCells
    151. Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91. PMID: 24337741.
      Citations: 60     Fields:    Translation:HumansCells
    152. Barbour JD, Jalbert EC, Chow DC, Gangcuangco LM, Norris PJ, Keating SM, Heitman J, Nagamine L, Seto T, Ndhlovu LC, Nakamoto BK, Hodis HN, Parikh NI, Shikuma CM. Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy. Atherosclerosis. 2014 Jan; 232(1):52-8. PMID: 24401216.
      Citations: 23     Fields:    Translation:HumansCells
    153. Chagan-Yasutan H, Ndhlovu LC, Lacuesta TL, Kubo T, Leano PS, Niki T, Oguma S, Morita K, Chew GM, Barbour JD, Telan EF, Hirashima M, Hattori T, Dimaano EM. Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection. J Clin Virol. 2013 Dec; 58(4):635-40. PMID: 24239423.
      Citations: 33     Fields:    Translation:HumansPHPublic Health
    154. Crawford TQ, Hecht FM, Pilcher CD, Ndhlovu LC, Barbour JD. Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection. PLoS One. 2013; 8(10):e77412. PMID: 24143233.
      Citations: 6     Fields:    Translation:HumansCells
    155. Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon DF, Ostrowski MA. LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells. J Virol. 2013 Dec; 87(24):13307-20. PMID: 24089548.
      Citations: 33     Fields:    Translation:HumansCells
    156. Jalbert E, Crawford TQ, D'Antoni ML, Keating SM, Norris PJ, Nakamoto BK, Seto T, Parikh NI, Shikuma CM, Ndhlovu LC, Barbour JD. IL-1? enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease. PLoS One. 2013; 8(9):e75500. PMID: 24086545.
      Citations: 28     Fields:    Translation:HumansCells
    157. Shikuma CM, Barbour JD, Ndhlovu LC, Keating SM, Norris PJ, Budoff M, Parikh N, Seto T, Gangcuangco LM, Ogata-Arakaki D, Chow D. Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-a levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors. AIDS Res Hum Retroviruses. 2014 Feb; 30(2):142-6. PMID: 23984974.
      Citations: 19     Fields:    Translation:Humans
    158. Tongma C, Shikuma CM, Nakamoto BK, Kallianpur KJ, Umaki TM, Barbour JD, Ndhlovu L, Parikh NI, Chow DC. Albuminuria as a marker of cardiovascular risk in HIV-infected individuals receiving stable antiretroviral therapy. Hawaii J Med Public Health. 2013 Sep; 72(9 Suppl 4):34-8. PMID: 24052917.
      Citations: 4     Fields:    Translation:Humans
    159. Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF. CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLoS One. 2013; 8(2):e52144. PMID: 23468834.
      Citations: 4     Fields:    Translation:HumansCells
    160. Leal FE, Ndhlovu LC, Hasenkrug AM, Bruno FR, Carvalho KI, Wynn-Williams H, Neto WK, Sanabani SS, Segurado AC, Nixon DF, Kallas EG. Expansion in CD39? CD4? immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. PLoS Negl Trop Dis. 2013; 7(2):e2028. PMID: 23409198.
      Citations: 17     Fields:    Translation:HumansCells
    161. Jalbert E, Shikuma CM, Ndhlovu LC, Barbour JD. Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry. Cytometry A. 2013 Mar; 83(3):280-6. PMID: 23426986.
      Citations: 11     Fields:    Translation:HumansCells
    162. Tandon R, Giret MT, Sengupta D, York VA, Wiznia AA, Rosenberg MG, Kallas EG, Ndhlovu LC, Nixon DF. Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. PLoS One. 2012; 7(9):e45733. PMID: 23029209.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    163. Ndhlovu LC, Lopez-Verg?s S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43. PMID: 22383801.
      Citations: 248     Fields:    Translation:HumansCells
    164. Crawford TQ, Ndhlovu LC, Tan A, Carvidi A, Hecht FM, Sinclair E, Barbour JD. HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses. J Virol. 2011 Dec; 85(23):12343-50. PMID: 21937661.
      Citations: 10     Fields:    Translation:HumansCells
    165. Tandon R, SenGupta D, Ndhlovu LC, Vieira RG, Jones RB, York VA, Vieira VA, Sharp ER, Wiznia AA, Ostrowski MA, Rosenberg MG, Nixon DF. Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects. J Virol. 2011 Nov; 85(21):11526-31. PMID: 21880743.
      Citations: 25     Fields:    Translation:HumansCellsPHPublic Health
    166. SenGupta D, Tandon R, Vieira RG, Ndhlovu LC, Lown-Hecht R, Ormsby CE, Loh L, Jones RB, Garrison KE, Martin JN, York VA, Spotts G, Reyes-Ter?n G, Ostrowski MA, Hecht FM, Deeks SG, Nixon DF. Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection. J Virol. 2011 Jul; 85(14):6977-85. PMID: 21525339.
      Citations: 41     Fields:    Translation:HumansCells
    167. Ndhlovu LC, Leal FE, Hasenkrug AM, Jha AR, Carvalho KI, Eccles-James IG, Bruno FR, Vieira RG, York VA, Chew GM, Jones RB, Tanaka Y, Neto WK, Sanabani SS, Ostrowski MA, Segurado AC, Nixon DF, Kallas EG. HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications. PLoS Negl Trop Dis. 2011 Apr 26; 5(4):e1030. PMID: 21541358.
      Citations: 15     Fields:    Translation:HumansCells
    168. Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-a and MIP1-?, a lack of IL-17, and a Th1-bias in males. PLoS One. 2010 Nov 03; 5(11):e15412. PMID: 21082024.
      Citations: 25     Fields:    Translation:HumansCells
    169. Ndhlovu LC, Sinclair E, Epling L, Tan QX, Ho T, Jha AR, Eccles-James I, Tincati C, Levy JA, Nixon DF, Hecht FM, Barbour JD. IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery. J Clin Immunol. 2010 Sep; 30(5):681-92. PMID: 20571894.
      Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
    170. Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Task?n K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF. A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties. Eur J Immunol. 2010 Jan; 40(1):134-41. PMID: 19877008.
      Citations: 8     Fields:    Translation:HumansCells
    171. Lanteri MC, O'Brien KM, Purtha WE, Cameron MJ, Lund JM, Owen RE, Heitman JW, Custer B, Hirschkorn DF, Tobler LH, Kiely N, Prince HE, Ndhlovu LC, Nixon DF, Kamel HT, Kelvin DJ, Busch MP, Rudensky AY, Diamond MS, Norris PJ. Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest. 2009 Nov; 119(11):3266-77. PMID: 19855131.
      Citations: 145     Fields:    Translation:HumansAnimalsCells
    172. Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Micha?lsson J, Nixon DF. Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. Blood. 2009 Nov 26; 114(23):4823-31. PMID: 19805616.
      Citations: 56     Fields:    Translation:HumansCells
    173. Ndhlovu LC, Snyder-Cappione JE, Carvalho KI, Leal FE, Loo CP, Bruno FR, Jha AR, Devita D, Hasenkrug AM, Barbosa HM, Segurado AC, Nixon DF, Murphy EL, Kallas EG. Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease. Clin Exp Immunol. 2009 Dec; 158(3):294-9. PMID: 19778295.
      Citations: 12     Fields:    Translation:HumansCells
    174. Melo KM, Carvalho KI, Bruno FR, Ndhlovu LC, Ballan WM, Nixon DF, Kallas EG, Costa-Carvalho BT. A decreased frequency of regulatory T cells in patients with common variable immunodeficiency. PLoS One. 2009 Jul 29; 4(7):e6269. PMID: 19649263.
      Citations: 27     Fields:    Translation:HumansCells
    175. Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Task?n K, Aandahl EM. Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. Eur J Immunol. 2009 May; 39(5):1280-7. PMID: 19384871.
      Citations: 8     Fields:    Translation:HumansCells
    176. Barbour JD, Ndhlovu LC, Xuan Tan Q, Ho T, Epling L, Bredt BM, Levy JA, Hecht FM, Sinclair E. High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication. PLoS One. 2009; 4(2):e4408. PMID: 19198651.
      Citations: 15     Fields:    Translation:HumansCells
    177. Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med. 2008 Nov 24; 205(12):2763-79. PMID: 19001139.
      Citations: 418     Fields:    Translation:HumansAnimalsCells
    178. Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N. Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells. Eur J Immunol. 2008 Aug; 38(8):2229-40. PMID: 18624295.
      Citations: 11     Fields:    Translation:AnimalsCells
    179. Ndhlovu LC, Chapman JM, Jha AR, Snyder-Cappione JE, Pag?n M, Leal FE, Boland BS, Norris PJ, Rosenberg MG, Nixon DF. Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. AIDS. 2008 May 11; 22(8):990-2. PMID: 18453860.
      Citations: 37     Fields:    Translation:HumansCells
    180. Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD. Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol. 2008 May; 82(10):4785-92. PMID: 18305035.
      Citations: 62     Fields:    Translation:HumansCells
    181. Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM. FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol. 2008 Feb; 83(2):254-62. PMID: 17982112.
      Citations: 44     Fields:    Translation:HumansCells
    182. Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF. T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog. 2007 Nov; 3(11):e165. PMID: 17997601.
      Citations: 77     Fields:    Translation:HumansCells
    183. Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, Ndhlovu LC, Soroosh P, Tada K, Harigae H, Kameoka J, Kasai N, Sasaki T, Sugamura K. Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol. 2006 Feb; 18(2):269-77. PMID: 16361311.
      Citations: 47     Fields:    Translation:HumansCells
    184. Takeda I, Ine S, Killeen N, Ndhlovu LC, Murata K, Satomi S, Sugamura K, Ishii N. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol. 2004 Mar 15; 172(6):3580-9. PMID: 15004159.
      Citations: 127     Fields:    Translation:AnimalsCells
    185. Ndhlovu LC, Takeda I, Sugamura K, Ishii N. Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells. Crit Rev Immunol. 2004; 24(4):251-66. PMID: 15588225.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    186. Ishii N, Ndhlovu LC, Murata K, Sato T, Kamanaka M, Sugamura K. OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses. Eur J Immunol. 2003 Sep; 33(9):2372-81. PMID: 12938213.
      Citations: 17     Fields:    Translation:AnimalsCells
    187. Sato T, Ishii N, Murata K, Kikuchi K, Nakagawa S, Ndhlovu LC, Sugamura K. Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur J Immunol. 2002 Nov; 32(11):3326-35. PMID: 12555678.
      Citations: 17     Fields:    Translation:AnimalsCells
    188. Murata K, Nose M, Ndhlovu LC, Sato T, Sugamura K, Ishii N. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol. 2002 Oct 15; 169(8):4628-36. PMID: 12370402.
      Citations: 46     Fields:    Translation:AnimalsCells
    189. Ndhlovu LC, Ishii N, Murata K, Sato T, Sugamura K. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J Immunol. 2001 Sep 01; 167(5):2991-9. PMID: 11509650.
      Citations: 34     Fields:    Translation:AnimalsCells
    190. Murata K, Ishii N, Takano H, Miura S, Ndhlovu LC, Nose M, Noda T, Sugamura K. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000 Jan 17; 191(2):365-74. PMID: 10637280.
      Citations: 90     Fields:    Translation:AnimalsCells
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