CD4-Positive T-Lymphocytes

"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Descriptor ID	D015496
MeSH Number(s)	A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
Concept/Terms	CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4 Positive T Lymphocytes CD4-Positive T-Lymphocyte T-Lymphocyte, CD4-Positive T-Lymphocytes, CD4-Positive CD4-Positive Lymphocytes CD4-Positive Lymphocyte Lymphocyte, CD4-Positive Lymphocytes, CD4-Positive T4 Cells T4 Cell T4 Lymphocytes T4 Lymphocyte

Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]

Below are MeSH descriptors whose meaning is related to "CD4-Positive T-Lymphocytes".

Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.

Bar chart showing 194 publications over 30 distinct years, with a maximum of 12 publications in 2010 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	3	2	5
1999	0	4	4
2000	3	1	4
2001	2	5	7
2002	3	3	6
2003	2	3	5
2004	5	5	10
2005	1	3	4
2006	5	4	9
2007	1	5	6
2008	7	2	9
2009	3	5	8
2010	5	7	12
2011	6	2	8
2012	5	5	10
2013	3	4	7
2014	6	2	8
2015	7	3	10
2016	7	5	12
2017	4	3	7
2018	5	1	6
2019	6	4	10
2020	1	1	2
2021	4	5	9
2022	0	1	1
2023	1	2	3
2024	4	4	8
2025	0	1	1

Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.

Cheng D, Luo Z, Ning W, Heath SL, Gisslen M, Price RW, Adekunle R, Salman T, Johnson D, McKinnon JE, Ndhlovu LC, Hossain R, Hu W, Jiang W. Systemic translocation of Staphylococcus aureus promotes autoimmunity: implications in autoantibody-mediated poor immune reconstitution from antiretroviral therapy in HIV. J Virol. 2026 May 19; 100(5):e0196525.

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Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.

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Okaa UJ, Ledesma Taira C, Dos Santos Dias L, Dobson H, Kujoth GC, Campuzano A, Homan EJ, Thompson GR, Hung CY, Deepe GS, W?thrich M, Klein BS. Endoglucanase 2 (Eng2), a shared immunodominant antigen in dimorphic fungi that elicits immunity during infection. J Clin Invest. 2025 Nov 17; 135(22).

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Ehrenberg PK, Geretz A, Volcic M, Izumi T, Yum LK, Waickman A, Shangguan S, Paquin-Proulx D, Creegan M, Bose M, Machmach K, McGraw A, Narahari A, Currier JR, Sacdalan C, Phanuphak N, Apps R, Corley M, Ndhlovu LC, Slike B, Krebs SJ, Anonworanich J, Tovanabutra S, Robb ML, Eller MA, Laird GM, Cyktor J, Daar ES, Crowell TA, Mellors JW, Vasan S, Michael NL, Kirchhoff F, Thomas R. Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts. Nat Commun. 2025 May 29; 16(1):4975.

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Prigann J, Tavora R, Furler O'Brien RL, Schulze-Gahmen U, Boehm D, Roan NR, Nixon DF, Ndhlovu LC, Valente S, Ott M. Silencing the transcriptionally active HIV reservoir to improve treatment outcomes. Nat Microbiol. 2024 Oct; 9(10):2470-2472.

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Moar P, Bowler S, Landay AL, Gianella S, Ndhlovu LC, Premeaux TA. Alterations in circulating immunoregulatory proteins discriminate poor CD4 T lymphocyte trajectories in people with HIV on suppressive antiretroviral therapy. mBio. 2024 Oct 16; 15(10):e0226524.

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Joseph J, Premeaux TA, Tandon R, Murphy EL, Bruhn R, Nicot C, Herrera BB, Lemenze A, Alatrash R, Baffour Tonto P, Ndhlovu LC, Jain P. Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response. Viruses. 2024 09 10; 16(9).

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Zhou Z, Guo J, Hetrick B, Tiwari S, Haikerwal A, Han Y, Bond VC, Huang MB, Mankowski MK, Snyder BA, Hogan PA, Sharma SK, Liotta DC, Reid TE, Wilson LJ, Wu Y. Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties. PLoS Pathog. 2024 Aug; 20(8):e1012448.

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Mori LP, Corley MJ, McAuley AT, Pang A, Venables T, Ndhlovu LC, Pipkin ME, Valente ST. Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1-infected CD4+ T cells. Life Sci Alliance. 2024 10; 7(10).

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Mitchell BI, Yazel Eiser IE, Kallianpur KJ, Gangcuangco LM, Chow DC, Ndhlovu LC, Paul R, Shikuma CM. Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection. J Neurovirol. 2024 12; 30(5-6):489-499.

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