CD4-Positive T-Lymphocytes

"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Descriptor ID	D015496
MeSH Number(s)	A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
Concept/Terms	CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4 Positive T Lymphocytes CD4-Positive T-Lymphocyte T-Lymphocyte, CD4-Positive T-Lymphocytes, CD4-Positive CD4-Positive Lymphocytes CD4-Positive Lymphocyte Lymphocyte, CD4-Positive Lymphocytes, CD4-Positive T4 Cells T4 Cell T4 Lymphocytes T4 Lymphocyte

Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]

Below are MeSH descriptors whose meaning is related to "CD4-Positive T-Lymphocytes".

Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.

Bar chart showing 184 publications over 29 distinct years, with a maximum of 12 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	3	2	5
1999	0	4	4
2000	3	0	3
2001	2	5	7
2002	3	3	6
2003	2	3	5
2004	5	5	10
2005	1	3	4
2006	5	4	9
2007	1	5	6
2008	6	2	8
2009	3	5	8
2010	5	6	11
2011	6	2	8
2012	6	5	11
2013	3	4	7
2014	6	2	8
2015	8	3	11
2016	7	5	12
2017	4	3	7
2018	3	1	4
2019	6	4	10
2020	1	0	1
2021	5	5	10
2022	0	2	2
2023	0	2	2
2024	1	1	2

Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.

Mori LP, Corley MJ, McAuley AT, Pang A, Venables T, Ndhlovu LC, Pipkin ME, Valente ST. Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1-infected CD4+ T cells. Life Sci Alliance. 2024 Oct; 7(10).

View in: PubMed
Obregon-Perko V, Mannino A, Ladner JT, Hodara V, Ebrahimi D, Parodi L, Callery J, Palacios G, Giavedoni LD. Adaptation of SIVmac to baboon primary cells results in complete absence of in vivo baboon infectivity. Front Cell Infect Microbiol. 2024; 14:1408245.

View in: PubMed
Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M. HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 2023 10 28; 15(11).

View in: PubMed
Moar P, Premeaux TA, Atkins A, Ndhlovu LC. The latent HIV reservoir: current advances in genetic sequencing approaches. mBio. 2023 Oct 31; 14(5):e0134423.

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Yuan Z, Giron LB, Hart C, Gyampoh A, Koshy J, Hong KY, Niki T, Premeaux TA, Ndhlovu LC, Deleage C, Montaner LJ, Abdel-Mohsen M. Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice. AIDS. 2023 03 15; 37(4):571-577.

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Usai C, Gibbons JM, Pade C, Li W, Jacobs SRM, McKnight ?, Kennedy PTF, Gill US. The ?-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19. Front Immunol. 2021; 12:813300.

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Corley MJ, Pang APS, Rasmussen TA, Tolstrup M, S?gaard OS, Ndhlovu LC. Candidate host epigenetic marks predictive for HIV reservoir size, responsiveness to latency reversal, and viral rebound. AIDS. 2021 11 15; 35(14):2269-2279.

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Zhang Z, Shi L, Song L, Maurer K, Zhao X, Zackai EH, McGinn DE, Crowley TB, McGinn DMM, Sullivan KE. Chromatin Modifications in 22q11.2 Deletion Syndrome. J Clin Immunol. 2021 11; 41(8):1853-1864.

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Corley MJ, Sacdalan C, Pang APS, Chomchey N, Ratnaratorn N, Valcour V, Kroon E, Cho KS, Belden AC, Colby D, Robb M, Hsu D, Spudich S, Paul R, Vasan S, Ndhlovu LC. Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART. PLoS Pathog. 2021 08; 17(8):e1009785.

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Shytaj IL, Procopio FA, Tarek M, Carlon-Andres I, Tang HY, Goldman AR, Munshi M, Kumar Pal V, Forcato M, Sreeram S, Leskov K, Ye F, Lucic B, Cruz N, Ndhlovu LC, Bicciato S, Padilla-Parra S, Diaz RS, Singh A, Lusic M, Karn J, Alvarez-Carbonell D, Savarino A. Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress. EMBO Mol Med. 2021 08 09; 13(8):e13901.

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