T-Lymphocytes, Regulatory

"T-Lymphocytes, Regulatory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Descriptor ID	D050378
MeSH Number(s)	A11.118.637.555.567.550.500.700 A11.118.637.555.567.569.200.700 A11.118.637.555.567.569.500.700 A15.145.229.637.555.567.550.500.700 A15.145.229.637.555.567.569.200.700 A15.145.229.637.555.567.569.500.700 A15.382.490.555.567.550.500.700 A15.382.490.555.567.569.200.700 A15.382.490.555.567.569.500.700
Concept/Terms	T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory T Lymphocytes, Regulatory Regulatory T-Lymphocytes Regulatory T Lymphocytes Regulatory T-Lymphocyte T-Lymphocyte, Regulatory Regulatory T-Cells Regulatory T Cells T-Cells, Regulatory T Cells, Regulatory Treg Cells Cell, Treg Cells, Treg Treg Cell Th3 Cells Th3 Cells Cell, Th3 Cells, Th3 Th3 Cell Suppressor T-Lymphocytes, Naturally-Occurring Suppressor T-Lymphocytes, Naturally-Occurring Naturally-Occurring Suppressor T-Lymphocyte Naturally-Occurring Suppressor T-Lymphocytes Suppressor T Lymphocytes, Naturally Occurring Suppressor T-Lymphocyte, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Naturally-Occurring Suppressor T-Cell Naturally-Occurring Suppressor T-Cells Suppressor T Cells, Naturally Occurring Suppressor T-Cell, Naturally-Occurring T-Cell, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Suppressor Tr1 Cells Tr1 Cells Cell, Tr1 Cells, Tr1 Tr1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Regulatory".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.550.500.700]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.200.700]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.500.700]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.550.500.700]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.200.700]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.500.700]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.550.500.700]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.200.700]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.500.700]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Regulatory".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Regulatory".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Regulatory" by people in this website by year, and whether "T-Lymphocytes, Regulatory" was a major or minor topic of these publications.

Bar chart showing 62 publications over 21 distinct years, with a maximum of 7 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	1	0	1
2004	2	1	3
2005	2	0	2
2006	2	0	2
2007	4	1	5
2008	1	2	3
2009	4	0	4
2010	1	0	1
2011	2	2	4
2012	1	0	1
2013	4	1	5
2014	2	1	3
2015	2	2	4
2016	1	1	2
2019	7	0	7
2020	1	2	3
2022	1	0	1
2023	1	3	4
2024	2	1	3
2025	3	0	3

Below are the most recent publications written about "T-Lymphocytes, Regulatory" by people in Profiles.

Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T?cells in hepatocellular carcinoma. Cell Rep Med. 2025 Apr 15; 6(4):102038.

View in: PubMed
Fox MM, Hassan A, Wiley KS, Kwon D, Knorr DA. Regulatory T-Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure. Am J Hum Biol. 2025 Mar; 37(3):e70013.

View in: PubMed
Wiley KS, Mart?nez LE, Kwon D, Knorr DA, Epeldegui M, Fox MM. Regulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women. Am J Reprod Immunol. 2025 Feb; 93(2):e70027.

View in: PubMed
Plascencia-Villa G, Castellani RJ, Perry G. Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2412255121.

View in: PubMed
Wiley KS, Kwon D, Knorr DA, Fox MM. Author Reply - Letter to the Editor "Regulatory T-cell phenotypes in prenatal psychological distress". Brain Behav Immun. 2024 05; 118:273-274.

View in: PubMed
Wood S, Branch J, Vasquez P, DeGuzman MM, Brown A, Sagcal-Gironella AC, Singla S, Ramirez A, Vogel TP. Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment. Pediatr Rheumatol Online J. 2024 Mar 02; 22(1):32.

View in: PubMed
Wiley KS, Kwon D, Knorr DA, Fox MM. Regulatory T-cell phenotypes in prenatal psychological distress. Brain Behav Immun. 2024 02; 116:62-69.

View in: PubMed
Shao TY, Jiang TT, Stevens J, Russi AE, Troutman TD, Bernieh A, Pham G, Erickson JJ, Eshleman EM, Alenghat T, Jameson SC, Hogquist KA, Weaver CT, Haslam DB, Deshmukh H, Way SS. Kruppel-like factor 2+ CD4 T?cells avert microbiota-induced intestinal inflammation. Cell Rep. 2023 11 28; 42(11):113323.

View in: PubMed
Steenbruggen TG, Wolf DM, Campbell MJ, Sanders J, Cornelissen S, Thijssen B, Salgado RA, Yau C, O-Grady N, Basu A, Bhaskaran R, Mittempergher L, Hirst GL, Coppe JP, Kok M, Sonke GS, van 't Veer LJ, Horlings HM. B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer. Breast Cancer Res. 2023 10 04; 25(1):117.

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Deng S, Jin P, Liu S, He Y, Sherchan P, Zhang JH, Gong Y, Tang J. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGF?/TGF?R/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol. 2023 09; 367:114451.

View in: PubMed

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