T-Lymphocytes, Cytotoxic

"T-Lymphocytes, Cytotoxic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

Descriptor ID	D013602
MeSH Number(s)	A11.118.637.555.283.875 A11.118.637.555.567.550.500.200 A11.118.637.555.567.569.220.200 A11.118.637.555.567.569.500.200 A15.145.229.637.555.283.875 A15.145.229.637.555.567.550.500.200 A15.145.229.637.555.567.569.220.200 A15.145.229.637.555.567.569.500.200 A15.382.490.555.283.875 A15.382.490.555.567.550.500.200 A15.382.490.555.567.569.220.200 A15.382.490.555.567.569.500.200
Concept/Terms	T-Lymphocytes, Cytotoxic T-Lymphocytes, Cytotoxic Cytotoxic T-Lymphocyte T Lymphocytes, Cytotoxic T-Lymphocyte, Cytotoxic Cell-Mediated Lympholytic Cells Cell Mediated Lympholytic Cells Cell, Cell-Mediated Lympholytic Cell-Mediated Lympholytic Cell Cells, Cell-Mediated Lympholytic Lympholytic Cell, Cell-Mediated Lympholytic Cells, Cell-Mediated Cytotoxic T-Lymphocytes Cytotoxic T Lymphocytes TC2 Cells TC2 Cells Cell, TC2 Cells, TC2 TC2 Cell TC1 Cells TC1 Cells Cell, TC1 Cells, TC1 TC1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Cytotoxic".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Cytokine-Induced Killer Cells [A11.118.637.555.283]
T-Lymphocytes, Cytotoxic [A11.118.637.555.283.875]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.550.500.200]
T-Lymphocytes [A11.118.637.555.567.569]
CD8-Positive T-Lymphocytes [A11.118.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.220.200]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.500.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Cytokine-Induced Killer Cells [A15.145.229.637.555.283]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.283.875]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.550.500.200]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD8-Positive T-Lymphocytes [A15.145.229.637.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.220.200]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.500.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Cytokine-Induced Killer Cells [A15.382.490.555.283]
T-Lymphocytes, Cytotoxic [A15.382.490.555.283.875]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.550.500.200]
T-Lymphocytes [A15.382.490.555.567.569]
CD8-Positive T-Lymphocytes [A15.382.490.555.567.569.220]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.220.200]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.500.200]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Cytotoxic".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Cytotoxic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Cytotoxic" by people in this website by year, and whether "T-Lymphocytes, Cytotoxic" was a major or minor topic of these publications.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 3 publications in 2000 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	3	3
2001	0	1	1
2003	1	0	1
2006	1	0	1
2008	0	1	1
2012	1	0	1
2015	0	1	1
2017	0	1	1
2019	3	0	3
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "T-Lymphocytes, Cytotoxic" by people in Profiles.

Del Vecchio F, Martinez-Rodriguez V, Schukking M, Cocks A, Broseghini E, Fabbri M. Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T-cells and tumour cells. J Extracell Vesicles. 2021 04; 10(6):e12075.

View in: PubMed
Principe N, Kidman J, Goh S, Tilsed CM, Fisher SA, Fear VS, Forbes CA, Zemek RM, Chopra A, Watson M, Dick IM, Boon L, Holt RA, Lake RA, Nowak AK, Lesterhuis WJ, McDonnell AM, Chee J. Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy. Front Immunol. 2020; 11:584423.

View in: PubMed
Sharma G, Rive CM, Holt RA. Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries. Nat Commun. 2019 10 07; 10(1):4553.

View in: PubMed
Uzhachenko RV, Shanker A. CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity. Front Immunol. 2019; 10:1906.

View in: PubMed
Tchekneva EE, Goruganthu MUL, Uzhachenko RV, Thomas PL, Antonucci A, Chekneva I, Koenig M, Piao L, Akhter A, de Aquino MTP, Ranganathan P, Long N, Magliery T, Valujskikh A, Evans JV, Arasada RR, Massion PP, Carbone DP, Shanker A, Dikov MM. Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T?cell immunity. J Immunother Cancer. 2019 04 02; 7(1):95.

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Mimura K, Teh JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, Fazreen Z, Asuncion BR, Shabbir A, Yong WP, So J, Soong R, Kono K. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 2018 Jan; 109(1):43-53.

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Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95.

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Ndhlovu LC, Lopez-Verg?s S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43.

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Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, Bansal A, Goepfert PA, Wynn KK, Ladell K, Price DA, N M, Kan-Mitchell J, Shankar P. Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA. Mol Ther. 2010 Nov; 18(11):2028-37.

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Weise JB, Csiszar K, Gottschlich S, Hoffmann M, Schmidt A, Weingartz U, Adamzik I, Heiser A, Kabelitz D, Ambrosch P, G?r?gh T. Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer. Int J Oncol. 2008 Feb; 32(2):317-22.

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