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Angela M. Thornton

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionFlorida A&M University
DepartmentCoPPS, IPH Pharmacy Practice Center
Address1415 S Martin Luther King Jr Blvd
306 West Wing
Tallahassee FL 32307
Phone8505993771
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. J Exp Med. 2021 10 04; 218(10). PMID: 34459852.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM. Corrigendum to "Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity" [J. Autoimmun. 105C (2019) 102300]. J Autoimmun. 2020 Nov; 114:102544. PMID: 32981806.
      Citations:    Fields:    
    3. Yang YH, Istomine R, Alvarez F, Al-Aubodah TA, Shi XQ, Takano T, Thornton AM, Shevach EM, Zhang J, Piccirillo CA. Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. Cell Rep. 2020 02 04; 30(5):1515-1529.e4. PMID: 32023466.
      Citations: 24     Fields:    Translation:AnimalsCells
    4. Thornton AM, Shevach EM. Helios: still behind the clouds. Immunology. 2019 11; 158(3):161-170. PMID: 31517385.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    5. Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM. Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. J Autoimmun. 2019 12; 105:102300. PMID: 31296356.
      Citations: 20     Fields:    Translation:AnimalsCells
    6. Skadow M, Penna VR, Galant-Swafford J, Shevach EM, Thornton AM. Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells. J Immunol. 2019 07 15; 203(2):370-378. PMID: 31167776.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Blackmer AB, Siu A, Thornton A, Johnson PN, Nichols KR, Hagemann TM. Academic Careers in Pediatric Pharmacy: Part 2-Academic Advancement. J Pediatr Pharmacol Ther. 2019 May-Jun; 24(3):183-193. PMID: 31093017.
      Citations:    
    8. Siu A, Blackmer AB, Thornton AM, Johnson PN, Nichols KR, Hagemann TM. Overview and Preparation Guide for Academic Careers in Pediatric Pharmacy, Part 1: Career as a Pediatric Pharmacy Practice Faculty Member. J Pediatr Pharmacol Ther. 2019 Mar-Apr; 24(2):79-89. PMID: 31019400.
      Citations:    
    9. Thornton AM, Lu J, Korty PE, Kim YC, Martens C, Sun PD, Shevach EM. Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires. Eur J Immunol. 2019 03; 49(3):398-412. PMID: 30620397.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    10. Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG. IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Cell Stem Cell. 2019 01 03; 24(1):153-165.e7. PMID: 30472158.
      Citations: 40     Fields:    Translation:AnimalsCells
    11. Thornton AM, Shevach EM. Tregs, Helios and tumor immunity: the sun has not yet risen. Transl Cancer Res. 2016 Oct; 5(Suppl 4):S672-S674. PMID: 30637198.
      Citations:    
    12. Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature. 2016 Mar 10; 531(7593):253-7. PMID: 26934227.
      Citations: 344     Fields:    Translation:HumansAnimalsCells
    13. Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM. Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol. 2016 Jan 01; 196(1):144-55. PMID: 26582951.
      Citations: 88     Fields:    Translation:AnimalsCells
    14. Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM. Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. J Immunol. 2015 Jul 15; 195(2):553-63. PMID: 26062998.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    15. Edwards JP, Thornton AM, Shevach EM. Release of active TGF-?1 from the latent TGF-?1/GARP complex on T regulatory cells is mediated by integrin ?8. J Immunol. 2014 Sep 15; 193(6):2843-9. PMID: 25127859.
      Citations: 52     Fields:    Translation:AnimalsCells
    16. Shevach EM, Thornton AM. tTregs, pTregs, and iTregs: similarities and differences. Immunol Rev. 2014 May; 259(1):88-102. PMID: 24712461.
      Citations: 270     Fields:    Translation:HumansAnimalsCells
    17. Ephrem A, Epstein AL, Stephens GL, Thornton AM, Glass D, Shevach EM. Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol. 2013 Sep; 43(9):2421-9. PMID: 23722868.
      Citations: 53     Fields:    Translation:AnimalsCells
    18. Kim YC, Bhairavabhotla R, Yoon J, Golding A, Thornton AM, Tran DQ, Shevach EM. Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion. Blood. 2012 Mar 22; 119(12):2810-8. PMID: 22294730.
      Citations: 64     Fields:    Translation:HumansCells
    19. Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A. The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor ? (TGF-?) signaling and the development of regulatory T cells. J Biol Chem. 2011 Nov 25; 286(47):40520-30. PMID: 21931165.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    20. Killebrew JR, Perdue N, Kwan A, Thornton AM, Shevach EM, Campbell DJ. A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. J Immunol. 2011 Jul 15; 187(2):861-9. PMID: 21690323.
      Citations: 23     Fields:    Translation:AnimalsCells
    21. Thornton AM, Zhao X, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M. Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle. Aging (Albany NY). 2011 Jun; 3(6):621-34. PMID: 21666285.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    22. Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010 Apr 01; 184(7):3433-41. PMID: 20181882.
      Citations: 676     Fields:    Translation:HumansAnimalsCells
    23. Pasquali P, Thornton AM, Vendetti S, Pistoia C, Petrucci P, Tarantino M, Pesciaroli M, Ruggeri F, Battistoni A, Shevach EM. CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice. Microbes Infect. 2010 Jan; 12(1):3-10. PMID: 19772948.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, Bast RC. Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2. Cell Cycle. 2008 Dec; 7(23):3747-58. PMID: 19029832.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko JK, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, Takeshima H, Ma J. MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol. 2009 Jan; 11(1):56-64. PMID: 19043407.
      Citations: 262     Fields:    Translation:AnimalsCells
    26. Eraikhuemen N, Thornton AM, Branch E, Huynh ST, Farley C. Combating Non-nucleoside Reverse Transcriptase Inhibitor Resistance with a Focus On Etravirine (Intelence) for HIV-1 Infection. P T. 2008 Aug; 33(8):445-91. PMID: 19750175.
      Citations:    
    27. Zhao X, Weisleder N, Thornton A, Oppong Y, Campbell R, Ma J, Brotto M. Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging Cell. 2008 Aug; 7(4):561-8. PMID: 18505477.
      Citations: 57     Fields:    Translation:AnimalsCells
    28. Kashyap M, Thornton AM, Norton SK, Barnstein B, Macey M, Brenzovich J, Shevach E, Leonard WJ, Ryan JJ. Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol. 2008 Feb 15; 180(4):2039-43. PMID: 18250408.
      Citations: 31     Fields:    Translation:AnimalsCells
    29. Brown CP, Ross L, Lopez I, Thornton A, Kiros GE. Disparities in the receipt of cardiac revascularization procedures between blacks and whites: an analysis of secular trends. Ethn Dis. 2008; 18(2 Suppl 2):S2-112-7. PMID: 18646331.
      Citations: 14     Fields:    Translation:Humans
    30. Min B, Thornton A, Caucheteux SM, Younes SA, Oh K, Hu-Li J, Paul WE. Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol. 2007 Jul; 37(7):1916-23. PMID: 17549737.
      Citations: 39     Fields:    Translation:AnimalsCells
    31. Adriani M, Aoki J, Horai R, Thornton AM, Konno A, Kirby M, Anderson SM, Siegel RM, Candotti F, Schwartzberg PL. Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol. 2007 Jul; 124(1):41-8. PMID: 17512803.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    32. Qiao M, Thornton AM, Shevach EM. CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive. Immunology. 2007 Apr; 120(4):447-55. PMID: 17244157.
      Citations: 15     Fields:    Translation:AnimalsCells
    33. Schmandt RE, Bennett M, Clifford S, Thornton A, Jiang F, Broaddus RR, Sun CC, Lu KH, Sood AK, Gershenson DM. The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary. Cancer Biol Ther. 2006 Sep; 5(9):1136-41. PMID: 16855388.
      Citations: 43     Fields:    Translation:HumansCells
    34. Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM. The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev. 2006 Aug; 212:60-73. PMID: 16903906.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    35. Hirata Y, Brotto M, Weisleder N, Chu Y, Lin P, Zhao X, Thornton A, Komazaki S, Takeshima H, Ma J, Pan Z. Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophys J. 2006 Jun 15; 90(12):4418-27. PMID: 16565048.
      Citations: 60     Fields:    Translation:AnimalsCells
    36. Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood. 2006 May 15; 107(10):3925-32. PMID: 16418326.
      Citations: 174     Fields:    Translation:AnimalsCells
    37. Thornton AM. Signal transduction in CD4+CD25+ regulatory T cells: CD25 and IL-2. Front Biosci. 2006 Jan 01; 11:921-7. PMID: 16146782.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    38. Thornton AM. T regulatory cells. Curr Biol. 2005 Aug 09; 15(15):R582. PMID: 16085474.
      Citations: 3     Fields:    Translation:HumansCells
    39. Piccirillo CA, Thornton AM. Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells. Trends Immunol. 2004 Jul; 25(7):374-80. PMID: 15207505.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    40. Thornton AM, Donovan EE, Piccirillo CA, Shevach EM. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol. 2004 Jun 01; 172(11):6519-23. PMID: 15153463.
      Citations: 185     Fields:    Translation:AnimalsCells
    41. Kruisbeek AM, Shevach E, Thornton AM. Proliferative assays for T cell function. Curr Protoc Immunol. 2004 May; Chapter 3:Unit 3.12. PMID: 18432927.
      Citations: 51     Fields:    Translation:AnimalsCells
    42. Thornton AM, Piccirillo CA, Shevach EM. Activation requirements for the induction of CD4+CD25+ T cell suppressor function. Eur J Immunol. 2004 Feb; 34(2):366-76. PMID: 14768041.
      Citations: 92     Fields:    Translation:AnimalsCells
    43. Thornton AM. Fractionation of T and B cells using magnetic beads. Curr Protoc Immunol. 2003 Nov; Chapter 3:Unit 3.5A. PMID: 18432907.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    44. Schmandt RE, Broaddus R, Lu KH, Shvartsman H, Thornton A, Malpica A, Sun C, Bodurka DC, Gershenson DM. Expression of c-ABL, c-KIT, and platelet-derived growth factor receptor-beta in ovarian serous carcinoma and normal ovarian surface epithelium. Cancer. 2003 Aug 15; 98(4):758-64. PMID: 12910520.
      Citations: 22     Fields:    Translation:Humans
    45. Shevach EM, Piccirillo CA, Thornton AM, McHugh RS. Control of T cell activation by CD4+CD25+ suppressor T cells. Novartis Found Symp. 2003; 252:24-36; discussion 36-44, 106-14. PMID: 14609210.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    46. Rebrikov D, Desai S, Kogan YN, Thornton AM, Diatchenko L. Subtractive cloning: new genes for studying inflammatory disorders. Ann Periodontol. 2002 Dec; 7(1):17-28. PMID: 16013213.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, Shevach EM. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med. 2002 Jul 15; 196(2):237-46. PMID: 12119348.
      Citations: 129     Fields:    Translation:AnimalsCells
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