Killer Cells, Natural

"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

Descriptor ID	D007694
MeSH Number(s)	A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
Concept/Terms	Killer Cells, Natural Killer Cells, Natural NK Cells Cell, NK Cells, NK NK Cell Natural Killer Cells Cell, Natural Killer Cells, Natural Killer Killer Cell, Natural Natural Killer Cell

Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Killer Cells, Natural [A11.118.637.555.567.537]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Killer Cells, Natural [A15.145.229.637.555.567.537]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Killer Cells, Natural [A15.382.490.555.567.537]

Below are MeSH descriptors whose meaning is related to "Killer Cells, Natural".

Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".

Killer Cells, Natural
Killer Cells, Lymphokine-Activated

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.

Bar chart showing 86 publications over 27 distinct years, with a maximum of 8 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	0	2
1999	0	1	1
2000	1	0	1
2002	4	4	8
2003	4	1	5
2004	2	0	2
2005	1	0	1
2006	2	1	3
2007	2	1	3
2008	5	2	7
2009	3	2	5
2010	1	1	2
2011	2	1	3
2012	4	1	5
2013	2	1	3
2014	1	1	2
2015	2	0	2
2016	1	0	1
2017	1	2	3
2018	1	1	2
2019	4	0	4
2020	1	0	1
2021	3	4	7
2022	1	1	2
2023	0	2	2
2024	3	1	4
2025	4	1	5

Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.

Beigel K, Alsaati N, Maurer K, McDonald-McGinn D, Crowley TB, Knight M, Henrickson SE, Bassett AS, Sullivan KE. Single cell RNA-seq analysis of hematopoietic cell types in 22q11.2 deletion syndrome reveals significant changes to non-T cells. Pediatr Allergy Immunol. 2025 11; 36(11):e70237.

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Toldo N, Wu Y, Fabbri M. Extracellular Vesicle microRNAs in the Crosstalk Between Cancer Cells and Natural Killer (NK) Cells. Cells. 2025 Oct 29; 14(21).

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Uzhachenko RV, Gonz?lez Ochoa S, Kanagasabai T, Rajakaruna H, Thounaojam MC, de Aquino MTP, Rana T, Costa L, Terekhov A, Hofmeister WH, Sayers TJ, Boyer C, Ivanova AV, Goodwin JS, Schmitt-Verhulst AM, Shanker A. CD8+ T-NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen-escape tumors. Front Immunol. 2025; 16:1593913.

View in: PubMed
Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD. Brain Behav Immun. 2025 Aug; 128:540-548.

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Nathani A, Sun L, Li Y, Lazarte J, Aare M, Singh M. Targeting EGFR-TKI resistance in lung cancer: Role of miR-5193/miR-149-5p loaded NK-EVs and Carboplatin combination. Int J Pharm. 2025 Apr 30; 675:125573.

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Dunbar ZT, Gonz?lez-Ochoa S, Kanagasabai T, Ivanova A, Shanker A. Differential Effector Function of Tissue-Specific Natural Killer Cells against Lung Tumors. J Innate Immun. 2024; 16(1):573-594.

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Boos D, Chuang TD, Abbasi A, Luzzi A, Khorram O. The immune landscape of uterine fibroids as determined by mass cytometry. F S Sci. 2024 08; 5(3):272-282.

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Webb GM, Pessoa CT, McCullen AJ, Hwang JM, Humkey MC, Thormin-Odum R, Kukula KA, Smedley J, Fischer M, Sciurba J, Bochart RM, Shriver-Munsch C, Ndhlovu LC, Sacha JB. Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection. J Virol. 2024 06 13; 98(6):e0027324.

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Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcaRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug; 17(4):692-699.

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Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK. Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism. PLoS Pathog. 2023 09; 19(9):e1011629.

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