"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
| Descriptor ID |
D007328
|
| MeSH Number(s) |
D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
|
| Concept/Terms |
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
|
Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 3 | 4 | 7 |
| 2003 | 2 | 1 | 3 |
| 2004 | 5 | 1 | 6 |
| 2005 | 4 | 5 | 9 |
| 2006 | 2 | 9 | 11 |
| 2007 | 3 | 5 | 8 |
| 2008 | 2 | 2 | 4 |
| 2009 | 6 | 2 | 8 |
| 2010 | 3 | 6 | 9 |
| 2011 | 6 | 9 | 15 |
| 2012 | 6 | 1 | 7 |
| 2013 | 6 | 5 | 11 |
| 2014 | 5 | 14 | 19 |
| 2015 | 7 | 4 | 11 |
| 2016 | 4 | 6 | 10 |
| 2017 | 2 | 4 | 6 |
| 2018 | 0 | 3 | 3 |
| 2019 | 6 | 3 | 9 |
| 2020 | 2 | 5 | 7 |
| 2021 | 2 | 5 | 7 |
| 2022 | 3 | 5 | 8 |
| 2023 | 0 | 4 | 4 |
| 2024 | 3 | 0 | 3 |
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Below are the most recent publications written about "Insulin" by people in Profiles.
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Haemmerle MW, Scota AV, Khosravifar M, Varney MJ, Sen S, Good AL, Yang X, Wells KL, Sussel L, Rozo AV, Doliba NM, Ghanem LR, Stoffers DA. RNA-binding protein PCBP2 regulates pancreatic ? cell function and adaptation to glucose. J Clin Invest. 2024 Jun 17; 134(12).
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Davidson MB, Davidson SJ. Real-world evidence for computerized insulin dose-adjustment algorithms in the effective use of continuous glucose monitoring by primary care clinicians. Diabetes Obes Metab. 2024 Aug; 26(8):3475-3477.
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Zhou AL, Swaminathan SK, Salian VS, Wang L, Curran GL, Min HK, Lowe VJ, Kandimalla KK. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Mol Pharm. 2024 May 06; 21(5):2176-2186.
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Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25; 14(1):7732.
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Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.
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Stensland ZC, Magera CA, Broncucia H, Gomez BD, Rios-Guzman NM, Wells KL, Nicholas CA, Rihanek M, Hunter MJ, Toole KP, Gottlieb PA, Smith MJ. Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients. J Exp Med. 2023 08 07; 220(8).
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Vass RA, Bell EF, Roghair RD, Kiss G, Funke S, Bokor S, Moln?r D, Miseta A, B?dis J, Kov?cs K, Ertl T. Insulin, Testosterone, and Albumin in Term and Preterm Breast Milk, Donor Milk, and Infant Formula. Nutrients. 2023 Mar 19; 15(6).
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Davidson MB. A simplified straightforward protocol for the use of U-500 regular insulin. Diabetes Obes Metab. 2023 02; 25(2):634-636.
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Wang Z, Tang X, Swaminathan SK, Kandimalla KK, Kalari KR. Mapping the dynamics of insulin-responsive pathways in the blood-brain barrier endothelium using time-series transcriptomics data. NPJ Syst Biol Appl. 2022 08 16; 8(1):29.
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Nakamura NK, Tokunaga DS, Ha HY, Polgar N. The Exocyst Is Required for CD36 Fatty Acid Translocase Trafficking and Free Fatty Acid Uptake in Skeletal Muscle Cells. Cells. 2022 08 06; 11(15).