Tumor Suppressor Protein p53

"Tumor Suppressor Protein p53" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Descriptor ID	D016159
MeSH Number(s)	D12.776.157.687.650 D12.776.260.820 D12.776.624.776.775 D12.776.660.720.650 D12.776.744.845
Concept/Terms	Tumor Suppressor Protein p53 Tumor Suppressor Protein p53 p53 Antigen TP53 Protein TRP53 Protein p53 Tumor Suppressor Protein pp53 Phosphoprotein Phosphoprotein, pp53 Cellular Tumor Antigen p53 Oncoprotein p53

Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p53".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Tumor Suppressor Protein p53 [D12.776.157.687.650]
DNA-Binding Proteins [D12.776.260]
Tumor Suppressor Protein p53 [D12.776.260.820]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Tumor Suppressor Protein p53 [D12.776.624.776.775]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Tumor Suppressor Protein p53 [D12.776.660.720.650]
Phosphoproteins [D12.776.744]
Tumor Suppressor Protein p53 [D12.776.744.845]

Below are MeSH descriptors whose meaning is related to "Tumor Suppressor Protein p53".

Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p53".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Suppressor Protein p53" by people in this website by year, and whether "Tumor Suppressor Protein p53" was a major or minor topic of these publications.

Bar chart showing 194 publications over 30 distinct years, with a maximum of 13 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	1	0	1
1998	1	1	2
1999	1	0	1
2000	3	2	5
2001	2	0	2
2002	4	1	5
2003	5	3	8
2004	3	1	4
2005	4	3	7
2006	8	3	11
2007	3	7	10
2008	3	3	6
2009	5	3	8
2010	2	3	5
2011	7	3	10
2012	8	5	13
2013	7	3	10
2014	3	3	6
2015	7	4	11
2016	2	1	3
2017	7	1	8
2018	2	4	6
2019	6	3	9
2020	5	1	6
2021	2	3	5
2022	2	6	8
2023	1	7	8
2024	3	4	7
2025	4	4	8

Below are the most recent publications written about "Tumor Suppressor Protein p53" by people in Profiles.

Montes-Rodr?guez IM, Centeno-Girona H, P?rez-M?rtir SV, Rivera N, Cruz-Correa M. Actionable Genes and Carcinogenic Pathways for Gastric Cancer in Latinos. Cancer Med. 2025 Sep; 14(17):e71216.

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Yao S, Wei L, Hu Q, Liu S, Manojlovic Z, Fiorica PN, Long M, Zirpoli GR, Cai Q, Long J, Ping J, Barnard ME, Jin Y, Murakami M, Wang J, Zhu Q, Davis W, Chen J, Ondracek RP, Khoury T, Gandhi S, Takabe K, Ko N, Sanderson M, Hong CC, Bandera EV, Craig DW, Ambrosone CB, Palmer JR, Zheng W, Carpten JD. Mutational landscape of triple-negative breast cancer in African American women. Nat Genet. 2025 Sep; 57(9):2166-2176.

View in: PubMed
Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J. A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin. Nucleic Acids Res. 2025 Jul 08; 53(13).

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Grigoruta M, Li L, Chen L, Meng F, Rosenblatt KP, Li Y, Grimm EA, Qin Y. S-Nitrosylation of p53 in Melanoma Cells Under Nitrosative Stress. Int J Mol Sci. 2025 Jul 06; 26(13).

View in: PubMed
Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology. 2026 Feb 01; 83(2):231-248.

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Yang L, Posner RG, Salanga MC, Traustad?ttir T, Guthrie OW. Long-term effects of acute hazardous noise on auditory and non-auditory organs. J Toxicol Environ Health A. 2025; 88(13):519-535.

View in: PubMed
Liu J, Shen Y, Liu J, Xu D, Chang CY, Wang J, Zhou J, Haffty BG, Zhang L, Bargonetti J, De S, Hu W, Feng Z. Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation. Nat Commun. 2025 Feb 19; 16(1):1762.

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Clements A, Enserro D, Strickland KC, Previs R, Matei D, Mutch D, Powell M, Klopp A, Miller DS, Small W, DiSilvestro P, Spirtos N, Cosgrove C, Sfakianos G, Liu JR, Vargas R, Shahin M, Corr B, Dessources K, Ueland F, Warshal D, Gillen J, Secord AA. Molecular classification of endometrial cancers (EC) and association with relapse-free survival (RFS) and overall survival (OS) outcomes: Ancillary analysis of GOG-0258. Gynecol Oncol. 2025 Feb; 193:119-129.

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Varriano S, Yu A, Xu YQ, Natelson DM, Ramadei A, Kleiman FE. Estrogen receptor alpha (ERa) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells. RNA Biol. 2024 01; 21(1):14-23.

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Islam SM, Hasan MM, Alam J, Dey A, Molineaux D. In Silico Screening, Molecular Dynamics Simulation and Binding Free Energy Identify Single-Point Mutations That Destabilize p53 and Reduce Binding to DNA. Proteins. 2025 Feb; 93(2):498-514.

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