Tumor Suppressor Protein p14ARF

"Tumor Suppressor Protein p14ARF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.

Descriptor ID	D025803
MeSH Number(s)	D12.776.167.600 D12.776.624.776.772
Concept/Terms	Tumor Suppressor Protein p14ARF Tumor Suppressor Protein p14ARF p14ARF Protein p14(ARF) p14ARF Cdkn2a(p14ARF) p(ARF) Protein

Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p14ARF".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Tumor Suppressor Protein p14ARF [D12.776.167.600]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Tumor Suppressor Protein p14ARF [D12.776.624.776.772]

Below are MeSH descriptors whose meaning is related to "Tumor Suppressor Protein p14ARF".

Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p14ARF".

publications

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This graph shows the total number of publications written about "Tumor Suppressor Protein p14ARF" by people in this website by year, and whether "Tumor Suppressor Protein p14ARF" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2002 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	0	2
2003	1	0	1
2006	1	1	2
2009	0	1	1
2011	1	0	1
2013	1	0	1
2016	1	0	1

Below are the most recent publications written about "Tumor Suppressor Protein p14ARF" by people in Profiles.

Xie Y, Lu W, Liu S, Yang Q, Goodwin JS, Sathyanarayana SA, Pratap S, Chen Z. MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo. Oncotarget. 2016 Jul 26; 7(30):47609-47619.

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Lu W, Xie Y, Ma Y, Matusik RJ, Chen Z. ARF represses androgen receptor transactivation in prostate cancer. Mol Endocrinol. 2013 Apr; 27(4):635-48.

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Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One. 2011 Apr 19; 6(4):e18828.

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Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009 Aug 18; 2(84):ra44.

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Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006 Nov 02; 444(7115):61-6.

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Kaul SC, Hasan K, Wadhwa R. CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints. Ann N Y Acad Sci. 2006 May; 1067:217-9.

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Ashktorab H, Ahmed A, Littleton G, Wang XW, Allen CR, Tackey R, Walters C, Smoot DT. p53 and p14 increase sensitivity of gastric cells to H. pylori-induced apoptosis. Dig Dis Sci. 2003 Jul; 48(7):1284-91.

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Zhu D, Xu G, Ghandhi S, Hubbard K. Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence. J Cell Physiol. 2002 Oct; 193(1):19-25.

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Weber HO, Samuel T, Rauch P, Funk JO. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene. 2002 May 09; 21(20):3207-12.

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