Origin Recognition Complex
"Origin Recognition Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The origin recognition complex is a multi-subunit DNA-binding protein that initiates DNA REPLICATION in eukaryotes.
| Descriptor ID |
D051738
|
| MeSH Number(s) |
D12.776.260.640
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Origin Recognition Complex".
Below are MeSH descriptors whose meaning is more specific than "Origin Recognition Complex".
This graph shows the total number of publications written about "Origin Recognition Complex" by people in this website by year, and whether "Origin Recognition Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Origin Recognition Complex" by people in Profiles.
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Nguyen H, Wu H, Ung A, Yamazaki Y, Fogelgren B, Ward WS. Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication?. Biol Reprod. 2022 04 26; 106(4):730-740.
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Nguyen H, Ung A, Ward WS. The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion. Syst Biol Reprod Med. 2020 Dec; 66(6):378-386.
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Nguyen H, Ward WS, James NG. Spatial and temporal resolution of mORC4 fluorescent variants reveals structural requirements for achieving higher order self-association and pronuclei entry. Methods Appl Fluoresc. 2019 May 16; 7(3):035002.
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Nguyen H, James NG, Nguyen L, Nguyen TP, Vuong C, Ortega MA, Jameson DM, Ward WS. Higher Order Oligomerization of the Licensing ORC4 Protein Is Required for Polar Body Extrusion in Murine Meiosis. J Cell Biochem. 2017 09; 118(9):2941-2949.
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Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016 Apr 05; 15(1):147-157.
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Ortega MA, Nguyen H, Ward WS. ORC proteins in the mammalian zygote. Cell Tissue Res. 2016 Jan; 363(1):195-200.
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Nguyen H, Ortega MA, Ko M, Marh J, Ward WS. ORC4 surrounds extruded chromatin in female meiosis. J Cell Biochem. 2015 May; 116(5):778-86.
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Ortega MA, Marh J, Alarcon VB, Ward WS. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep; 87(3):62.
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Valenzuela MS, Hu L, Lueders J, Walker R, Meltzer PS. Broader utilization of origins of DNA replication in cancer cell lines along a 78?kb region of human chromosome 2q34. J Cell Biochem. 2012 Jan; 113(1):132-40.
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Davey MJ, Jeruzalmi D, Kuriyan J, O'Donnell M. Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol. 2002 Nov; 3(11):826-35.