Cyclin-Dependent Kinase Inhibitor p21

"Cyclin-Dependent Kinase Inhibitor p21" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.

Descriptor ID	D050759
MeSH Number(s)	D12.644.360.225.500 D12.776.157.687.250 D12.776.167.187.500 D12.776.476.225.500 D12.776.624.776.355.500 D12.776.660.720.250
Concept/Terms	Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Cyclin Dependent Kinase Inhibitor p21 CDKN1 Protein Senescent Cell-Derived Inhibitor Protein 1 Senescent Cell Derived Inhibitor Protein 1 Cell Cycle Regulator p21 Cyclin-Dependent Kinase Inhibitor 1A Protein Cyclin Dependent Kinase Inhibitor 1A Protein Cyclin Kinase Inhibitor p21 p21 Cyclin Kinase Inhibitor CDKN1A Protein Cdk-Interacting Protein 1 Cdk Interacting Protein 1 Cdk2 Inhibitor Protein CDK2-Associated Protein 20 kDa CDK2 Associated Protein 20 kDa p21 Cell Cycle Regulator

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p21".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.644.360.225.500]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.157.687.250]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.167.187.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.476.225.500]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.624.776.355.500]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.660.720.250]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor p21".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p21".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p21" was a major or minor topic of these publications.

Bar chart showing 47 publications over 21 distinct years, with a maximum of 6 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	0	5	5
2003	0	1	1
2004	0	1	1
2005	0	2	2
2006	3	3	6
2007	1	3	4
2009	0	3	3
2010	1	3	4
2011	0	1	1
2012	0	5	5
2013	1	0	1
2014	0	2	2
2016	0	1	1
2017	1	1	2
2019	0	2	2
2023	0	2	2
2025	0	1	1
2026	1	0	1

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in Profiles.

Walker D, Hall A, Bonwell A, Gordon N, Robinson D, Hollomon MG. FOXO1 Inhibition and FADD Knockdown Have Opposing Effects on Anticancer Drug-Induced Cytotoxicity and p21 Expression in Osteosarcoma Cells. Int J Mol Sci. 2026 Jan 17; 27(2).

View in: PubMed
Chen Q, Dorji JP, Perera SG, Li P, Aijaz F, Ihuoma LC, Matsui H, Awah CU. In vivo inhibition of c-MYC in the metastatic drug-resistant ovarian cancer cells down regulates the c-MYC-PD-L1-PAX8-p21 to achieve therapeutic efficacy. BMC Cancer. 2025 Dec 10; 26(1):68.

View in: PubMed
Murphy MR, Ramadei A, Doymaz A, Varriano S, Natelson DM, Yu A, Aktas S, Mazzeo M, Mazzeo M, Zakusilo G, Kleiman FE. Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response. Nucleic Acids Res. 2023 11 27; 51(21):11911-11926.

View in: PubMed
Shimoyama Y, Yamada K, Yoshida S, Kawamura A, Hannya Y, Imaizumi Y, Kumamoto T, Takeda Y, Shimoda M, Eto K, Yoshida K. Inhibition of protein kinase C delta leads to cellular senescence to induce anti-tumor effects in colorectal cancer. Cancer Sci. 2023 Jun; 114(6):2471-2484.

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Kanagasabai T, Venkatesan T, Natarajan U, Alobid S, Alhazzani K, Algahtani M, Rathinavelu A. Regulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways. Cell Signal. 2020 02; 66:109435.

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Zhang Z, Garzotto M, Davis EW, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J. Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutr Cancer. 2020; 72(1):74-87.

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Zhao M, Howard EW, Guo Z, Parris AB, Yang X. p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells. PLoS One. 2017; 12(4):e0175121.

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Singh SK, Banerjee S, Acosta EP, Lillard JW, Singh R. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget. 2017 Mar 07; 8(10):17216-17228.

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Ramadoss S, Sen S, Ramachandran I, Roy S, Chaudhuri G, Farias-Eisner R. Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance. Oncogene. 2017 03; 36(11):1537-1545.

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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500.

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