Apoptosis Inducing Factor
"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
| Descriptor ID |
D051033
|
| MeSH Number(s) |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
|
| Concept/Terms |
Apoptosis Inducing Factor- Apoptosis Inducing Factor
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor
- AIF Apoptosis Regulatory Protein
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis Inducing Factor".
This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in this website by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Apoptosis Inducing Factor" by people in Profiles.
-
Kadam AA, Jubin T, Mir HA, Begum R. Potential role of Apoptosis Inducing Factor in evolutionarily significant eukaryote, Dictyostelium discoideum survival. Biochim Biophys Acta Gen Subj. 2017 Jan; 1861(1 Pt A):2942-2955.
-
Ashktorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, Lee EL, Daremipouran M, Nouraie M, Malekzadeh R, Smoot DT. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter. 2008 Dec; 13(6):506-17.
-
Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M. NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovasc Res. 2008 Jan 15; 77(2):416-24.
-
Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC. Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. J Cereb Blood Flow Metab. 2006 Apr; 26(4):583-9.
-
Shanker A, Singh SM, Sodhi A. Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution. 2. Induction of apoptosis in thymocytes. Tumour Biol. 2000 Nov-Dec; 21(6):315-27.
-
Shanker A, Singh SM. Characterization of factors inducing apoptosis in thymocytes of mice bearing a transplantable T-cell lymphoma of spontaneous origin. Neoplasma. 2000; 47(2):90-5.