Electron Transport Complex I

"Electron Transport Complex I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

Descriptor ID	D042967
MeSH Number(s)	D05.500.562.249 D08.811.600.250.500.500 D08.811.682.608.504 D12.776.157.427.374.375.863 D12.776.157.530.450.250.875.300 D12.776.331.199.500 D12.776.543.277.500.500 D12.776.543.585.450.250.875.437 D12.776.556.579.374.375.140
Concept/Terms	Electron Transport Complex I Electron Transport Complex I Respiratory Complex I NADH Dehydrogenase (Ubiquinone) NADH Dehydrogenase (Ubiquinone) NADH Dehydrogenase Complex 1 NADH Dehydrogenase I NADH DH I Ubiquinone Reductase NADH-Coenzyme Q Reductase NADH Coenzyme Q Reductase NADH-CoQ Reductase NADH CoQ Reductase NADH-Ubiquinone Oxidoreductase NADH Ubiquinone Oxidoreductase Oxidoreductase, NADH-Ubiquinone NADH-Ubiquinone Reductase NADH Ubiquinone Reductase Reductase, NADH-Ubiquinone Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase Complex I Dehydrogenase Dehydrogenase, Complex I NADH Q1 Oxidoreductase Oxidoreductase, NADH Q1

Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex I".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Electron Transport Complex I [D05.500.562.249]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Electron Transport Chain Complex Proteins [D08.811.600.250]
Electron-Transferring Flavoproteins [D08.811.600.250.500]
Electron Transport Complex I [D08.811.600.250.500.500]
Oxidoreductases [D08.811.682]
NADH, NADPH Oxidoreductases [D08.811.682.608]
Electron Transport Complex I [D08.811.682.608.504]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Iron-Binding Proteins [D12.776.157.427]
Nonheme Iron Proteins [D12.776.157.427.374]
Iron-Sulfur Proteins [D12.776.157.427.374.375]
Electron Transport Complex I [D12.776.157.427.374.375.863]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Cation Transport Proteins [D12.776.157.530.450.250]
Proton Pumps [D12.776.157.530.450.250.875]
Electron Transport Complex I [D12.776.157.530.450.250.875.300]
Flavoproteins [D12.776.331]
Electron-Transferring Flavoproteins [D12.776.331.199]
Electron Transport Complex I [D12.776.331.199.500]
Membrane Proteins [D12.776.543]
Electron Transport Chain Complex Proteins [D12.776.543.277]
Electron-Transferring Flavoproteins [D12.776.543.277.500]
Electron Transport Complex I [D12.776.543.277.500.500]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Cation Transport Proteins [D12.776.543.585.450.250]
Proton Pumps [D12.776.543.585.450.250.875]
Electron Transport Complex I [D12.776.543.585.450.250.875.437]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Iron-Sulfur Proteins [D12.776.556.579.374.375]
Electron Transport Complex I [D12.776.556.579.374.375.140]

Below are MeSH descriptors whose meaning is related to "Electron Transport Complex I".

Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex I".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Electron Transport Complex I" by people in this website by year, and whether "Electron Transport Complex I" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 4 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2009	0	1	1
2012	0	1	1
2013	0	2	2
2015	0	2	2
2016	0	1	1
2017	1	1	2
2018	1	0	1
2019	0	1	1
2020	1	0	1
2021	1	1	2
2023	1	0	1
2024	0	4	4

Below are the most recent publications written about "Electron Transport Complex I" by people in Profiles.

Uddin MR, Khaniya U, Gupta C, Mao J, Ranepura GA, Wei RJ, Ortiz-Soto J, Singharoy A, Gunner MR. Finding the E-channel proton loading sites by calculating the ensemble of protonation microstates. Biochim Biophys Acta Bioenerg. 2025 01 01; 1866(1):149518.

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Kami Reddy KR, Piyarathna DWB, Park JH, Putluri V, Amara CS, Kamal AHM, Xu J, Kraushaar D, Huang S, Jung SY, Eberlin LS, Johnson JR, Kittles RA, Ballester LY, Parsawar K, Siddiqui MM, Gao J, Langer Gramer A, Bollag RJ, Terris MK, Lotan Y, Creighton CJ, Lerner SP, Sreekumar A, Kaipparettu BA, Putluri N. Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer. JCI Insight. 2024 Sep 10; 9(17).

View in: PubMed
Gojanovich GS, Yu W, Zhang ZJ, Jacobson DL, Yao TJ, Jao J, Libutti DE, Geffner ME, Gerschenson M. Longitudinal changes in mitochondrial-associated measures and insulin resistance in youth with perinatally-acquired HIV in the U.S. Mitochondrion. 2024 Sep; 78:101936.

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Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun. 2024 Mar 04; 15(1):1965.

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Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ. NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer Biol Ther. 2023 12 31; 24(1):2170669.

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Kim HJ, Kato N, Ndathe R, Thyssen GN, Jones DC, Ratnayaka HH. Evidence for thermosensitivity of the cotton (Gossypium hirsutum L.) immature fiber (im) mutant via hypersensitive stomatal activity. PLoS One. 2021; 16(12):e0259562.

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Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O'Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E. Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol. 2021 01 08; 4(1):61.

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Khaniya U, Gupta C, Cai X, Mao J, Kaur D, Zhang Y, Singharoy A, Gunner MR. Hydrogen bond network analysis reveals the pathway for the proton transfer in the E-channel of T. thermophilus Complex I. Biochim Biophys Acta Bioenerg. 2020 10 01; 1861(10):148240.

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M Parodi-Rull?n R, Chapa-Dubocq X, Guzm?n-Hern?ndez R, Jang S, A Torres-Ramos C, Ayala-Pe?a S, Javadov S. The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells. Cells. 2019 10 13; 8(10).

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Jang S, Javadov S. Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria. Sci Rep. 2018 12 07; 8(1):17732.

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