Iron Regulatory Protein 1
"Iron Regulatory Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
| Descriptor ID |
D035941
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| MeSH Number(s) |
D08.811.520.241.300.050.500 D12.776.157.427.374.375.960 D12.776.157.725.374 D12.776.494.500 D12.776.556.579.374.375.960 D12.776.664.962.374
|
| Concept/Terms |
Iron Regulatory Protein 1- Iron Regulatory Protein 1
- IRP-1 Protein
- IRP 1 Protein
- IRP1 Protein
- ACO1 Protein
- Aconitase 1, Soluble
- Soluble Aconitase 1
- IRE-BP1
- IRE BP1
- Ferritin Repressor Protein
- Repressor Protein, Ferritin
|
Below are MeSH descriptors whose meaning is more general than "Iron Regulatory Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Iron Regulatory Protein 1".
This graph shows the total number of publications written about "Iron Regulatory Protein 1" by people in this website by year, and whether "Iron Regulatory Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Iron Regulatory Protein 1" by people in Profiles.
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Khan MA, Walden WE, Theil EC, Goss DJ. Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1. Sci Rep. 2017 08 17; 7(1):8532.
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Khan MA, Ma J, Walden WE, Merrick WC, Theil EC, Goss DJ. Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions. Nucleic Acids Res. 2014 Jun; 42(10):6567-77.
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Goss DJ, Theil EC. Iron responsive mRNAs: a family of Fe2+ sensitive riboregulators. Acc Chem Res. 2011 Dec 20; 44(12):1320-8.
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Lee HP, Zhu X, Liu G, Chen SG, Perry G, Smith MA, Lee HG. Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship. Cell Res. 2010 Apr; 20(4):397-9.
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Smith MA, Wehr K, Harris PL, Siedlak SL, Connor JR, Perry G. Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res. 1998 Mar 30; 788(1-2):232-6.