Eukaryotic Initiation Factor-4G
"Eukaryotic Initiation Factor-4G" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of eukaryotic initiation factor-4F that is involved in multiple protein interactions at the site of translation initiation. Thus it may serve a role in bringing together various initiation factors at the site of translation initiation.
| Descriptor ID |
D039603
|
| MeSH Number(s) |
D12.776.835.725.868.500.875
|
| Concept/Terms |
Eukaryotic Initiation Factor-4G- Eukaryotic Initiation Factor-4G
- Eukaryotic Initiation Factor 4G
- EIF4G
- Peptide Initiation Factor EIF-4G
- Peptide Initiation Factor EIF 4G
- Eukaryotic Translation Initiation Factor 4 gamma
- Eukaryotic-Translation Initiation Factor 4G
- Eukaryotic Translation Initiation Factor 4G
- EIF-4G
- EIF 4G
- Eukaryotic Peptide Initiation Factor-4G
- Eukaryotic Peptide Initiation Factor 4G
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4G".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4G".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4G" by people in this website by year, and whether "Eukaryotic Initiation Factor-4G" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4G" by people in Profiles.
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Saha B, Bhardwaj U, Goss DJ. Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs. Biochemistry. 2023 06 06; 62(11):1767-1775.
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Haizel SA, Bhardwaj U, Gonzalez RL, Mitra S, Goss DJ. 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs. J Biol Chem. 2020 08 14; 295(33):11693-11706.
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Zhao P, Liu Q, Miller WA, Goss DJ. Eukaryotic translation initiation factor 4G (eIF4G) coordinates interactions with eIF4A, eIF4B, and eIF4E in binding and translation of the barley yellow dwarf virus 3' cap-independent translation element (BTE). J Biol Chem. 2017 04 07; 292(14):5921-5931.
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de la Parra C, Borrero-Garcia LD, Cruz-Collazo A, Schneider RJ, Dharmawardhane S. Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G. J Biol Chem. 2015 Mar 06; 290(10):6047-57.
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de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. J Biol Chem. 2012 Dec 07; 287(50):41640-50.
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Mart?nez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF. Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutr Cancer. 2011; 63(7):1085-94.
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Ozpolat B, Akar U, Zorrilla-Calancha I, Vivas-Mejia P, Acevedo-Alvarez M, Lopez-Berestein G. Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Apoptosis. 2008 Jul; 13(7):915-28.
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Ray S, Yumak H, Domashevskiy A, Khan MA, Gallie DR, Goss DJ. Tobacco etch virus mRNA preferentially binds wheat germ eukaryotic initiation factor (eIF) 4G rather than eIFiso4G. J Biol Chem. 2006 Nov 24; 281(47):35826-34.
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Khan MA, Goss DJ. Phosphorylation states of translational initiation factors affect mRNA cap binding in wheat. Biochemistry. 2004 Jul 20; 43(28):9092-7.