"RNA Caps" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
| Descriptor ID |
D012315
|
| MeSH Number(s) |
D03.633.100.759.646.454.700 D13.444.735.544.500 D13.695.667.454.700 D13.695.827.426.700
|
| Concept/Terms |
RNA Caps- RNA Caps
- Caps, RNA
- 5' Capped RNA
- RNA, 5' Capped
- 5' mRNA Cap Structure
|
Below are MeSH descriptors whose meaning is more general than "RNA Caps".
Below are MeSH descriptors whose meaning is more specific than "RNA Caps".
This graph shows the total number of publications written about "RNA Caps" by people in this website by year, and whether "RNA Caps" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA Caps" by people in Profiles.
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Saha B, Bhardwaj U, Goss DJ. Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs. Biochemistry. 2023 06 06; 62(11):1767-1775.
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Haizel SA, Bhardwaj U, Gonzalez RL, Mitra S, Goss DJ. 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs. J Biol Chem. 2020 08 14; 295(33):11693-11706.
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Bhardwaj U, Powell P, Goss DJ. Eukaryotic initiation factor (eIF) 3 mediates Barley Yellow Dwarf Viral mRNA 3'-5' UTR interactions and 40S ribosomal subunit binding to facilitate cap-independent translation. Nucleic Acids Res. 2019 07 09; 47(12):6225-6235.
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Khan MA, Goss DJ. Kinetic analyses of phosphorylated and non-phosphorylated eIFiso4E binding to mRNA cap analogues. Int J Biol Macromol. 2018 Jan; 106:387-395.
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Sharma SD, Kraft JJ, Miller WA, Goss DJ. Recruitment of the 40S ribosome subunit to the 3'-untranslated region (UTR) of a viral mRNA, via the eIF4 complex, facilitates cap-independent translation. J Biol Chem. 2015 May 01; 290(18):11268-81.
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Domashevskiy AV, Goss DJ. Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects. Toxins (Basel). 2015 Jan 28; 7(2):274-98.
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Khan MA, Yumak H, Goss DJ. Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein. J Biol Chem. 2009 Dec 18; 284(51):35461-70.
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Khan MA, Miyoshi H, Gallie DR, Goss DJ. Potyvirus genome-linked protein, VPg, directly affects wheat germ in vitro translation: interactions with translation initiation factors eIF4F and eIFiso4F. J Biol Chem. 2008 Jan 18; 283(3):1340-1349.
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Khan MA, Goss DJ. Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP. Biochemistry. 2005 Mar 22; 44(11):4510-6.
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Khan MA, Goss DJ. Phosphorylation states of translational initiation factors affect mRNA cap binding in wheat. Biochemistry. 2004 Jul 20; 43(28):9092-7.