Eukaryotic Initiation Factor-4F
"Eukaryotic Initiation Factor-4F" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A trimeric peptide initiation factor complex that associates with the 5' MRNA cap structure of RNA (RNA CAPS) and plays an essential role in MRNA TRANSLATION. It is composed of EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; and EUKARYOTIC INITIATION FACTOR-4G.
| Descriptor ID |
D039562
|
| MeSH Number(s) |
D12.776.664.962.750.374 D12.776.835.725.868.500
|
| Concept/Terms |
Eukaryotic Initiation Factor-4F- Eukaryotic Initiation Factor-4F
- Eukaryotic Initiation Factor 4F
- Initiation Factor-4F, Eukaryotic
- Protein Initiation Factor EIF-4F
- Protein Initiation Factor EIF 4F
- EIF4F Translation Initiation Complex
- Peptide Initiation Factor EIF-4F
- Peptide Initiation Factor EIF 4F
- EIF-4F
- EIF 4F
- EIF4F
EIF-(iso)4F- EIF-(iso)4F
- Eukaryotic Initiation Factor-(iso)4F
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4F".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4F".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4F" by people in this website by year, and whether "Eukaryotic Initiation Factor-4F" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4F" by people in Profiles.
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Powell P, Bhardwaj U, Goss D. Eukaryotic initiation factor 4F promotes a reorientation of eukaryotic initiation factor 3 binding on the 5' and the 3' UTRs of barley yellow dwarf virus mRNA. Nucleic Acids Res. 2022 05 20; 50(9):4988-4999.
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Khan MA, Goss DJ. Poly (A) binding protein enhances the binding affinity of potyvirus VPg to eukaryotic initiation factor eIF4F and activates in vitro translation. Int J Biol Macromol. 2019 Jan; 121:947-955.
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Liu Q, Goss DJ. The 3' mRNA I-shaped structure of maize necrotic streak virus binds to eukaryotic translation factors for eIF4F-mediated translation initiation. J Biol Chem. 2018 06 15; 293(24):9486-9495.
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Sharma SD, Kraft JJ, Miller WA, Goss DJ. Recruitment of the 40S ribosome subunit to the 3'-untranslated region (UTR) of a viral mRNA, via the eIF4 complex, facilitates cap-independent translation. J Biol Chem. 2015 May 01; 290(18):11268-81.
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Khan MA, Ma J, Walden WE, Merrick WC, Theil EC, Goss DJ. Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions. Nucleic Acids Res. 2014 Jun; 42(10):6567-77.
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Banerjee B, Goss DJ. Eukaryotic initiation factor (eIF) 4F binding to barley yellow dwarf virus (BYDV) 3'-untranslated region correlates with translation efficiency. J Biol Chem. 2014 Feb 14; 289(7):4286-94.
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Ma J, Haldar S, Khan MA, Sharma SD, Merrick WC, Theil EC, Goss DJ. Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8417-22.
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Khan MA, Goss DJ. Poly(A)-binding protein increases the binding affinity and kinetic rates of interaction of viral protein linked to genome with translation initiation factors eIFiso4F and eIFiso4F?4B complex. Biochemistry. 2012 Feb 21; 51(7):1388-95.
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Yumak H, Khan MA, Goss DJ. Poly(A) tail affects equilibrium and thermodynamic behavior of tobacco etch virus mRNA with translation initiation factors eIF4F, eIF4B and PABP. Biochim Biophys Acta. 2010 Sep; 1799(9):653-8.
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Khan MA, Yumak H, Goss DJ. Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein. J Biol Chem. 2009 Dec 18; 284(51):35461-70.