Eukaryotic Initiation Factor-4E
"Eukaryotic Initiation Factor-4E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.
| Descriptor ID |
D039561
|
| MeSH Number(s) |
D12.776.157.725.750.374 D12.776.835.725.868.500.750
|
| Concept/Terms |
Eukaryotic Initiation Factor-4E- Eukaryotic Initiation Factor-4E
- Eukaryotic Initiation Factor 4E
- Factor-4E, Eukaryotic Initiation
- Initiation Factor-4E, Eukaryotic
- Peptide Initiation Factor EIF-4E
- Peptide Initiation Factor EIF 4E
- EIF4E
- Eukaryotic Peptide Initiation Factor-4E
- Eukaryotic Peptide Initiation Factor 4E
- CDC33 Gene Product
- EIF-4E
- EIF 4E
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4E".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4E".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4E" by people in this website by year, and whether "Eukaryotic Initiation Factor-4E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Eukaryotic Initiation Factor-4E" by people in Profiles.
-
Saha B, Bhardwaj U, Goss DJ. Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs. Biochemistry. 2023 06 06; 62(11):1767-1775.
-
Khan MA, Goss DJ. Kinetic analyses of phosphorylated and non-phosphorylated eIFiso4E binding to mRNA cap analogues. Int J Biol Macromol. 2018 Jan; 106:387-395.
-
Zhao P, Liu Q, Miller WA, Goss DJ. Eukaryotic translation initiation factor 4G (eIF4G) coordinates interactions with eIF4A, eIF4B, and eIF4E in binding and translation of the barley yellow dwarf virus 3' cap-independent translation element (BTE). J Biol Chem. 2017 04 07; 292(14):5921-5931.
-
Le Gendre O, Sookdeo A, Duliepre SA, Utter M, Frias M, Foster DA. Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells. Mol Cancer Res. 2013 May; 11(5):474-81.
-
Yellen P, Chatterjee A, Preda A, Foster DA. Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-?-dependent G1 cell cycle arrest. Cancer Lett. 2013 Jun 10; 333(2):239-43.
-
de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. J Biol Chem. 2012 Dec 07; 287(50):41640-50.
-
Ziaei S, Shimada N, Kucharavy H, Hubbard K. MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1. Exp Cell Res. 2012 Mar 10; 318(5):500-8.
-
Janzen C, Sen S, Cuevas J, Reddy ST, Chaudhuri G. Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-a. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2586-94.
-
Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007 Jan 01; 67(1):289-99.
-
Khan MA, Miyoshi H, Ray S, Natsuaki T, Suehiro N, Goss DJ. Interaction of genome-linked protein (VPg) of turnip mosaic virus with wheat germ translation initiation factors eIFiso4E and eIFiso4F. J Biol Chem. 2006 Sep 22; 281(38):28002-10.