Immunoglobulin Variable Region

"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Descriptor ID	D007135
MeSH Number(s)	D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
Concept/Terms	Immunoglobulin Variable Region Immunoglobulin Variable Region Immunoglobulin Variable Regions Regions, Immunoglobulin Variable Variable Regions, Immunoglobulin Ig Variable Region Variable Region, Ig Ig Variable Regions Variable Regions, Ig Variable Region, Immunoglobulin Immunoglobulin V Immunoglobulin Fv Fragments Immunoglobulin Fv Fragments Fragment, Immunoglobulin Fv Fragments, Immunoglobulin Fv Fv Fragment, Immunoglobulin Fv Fragments, Immunoglobulin Immunoglobulin Fv Fragment Fv Antibody Fragments Antibody Fragment, Fv Antibody Fragments, Fv Fragment, Fv Antibody Fragments, Fv Antibody Fv Antibody Fragment Fv Fragments Fragment, Fv Fragments, Fv Fv Fragment Framework Region, Immunoglobulin Framework Region, Immunoglobulin Framework Regions, Immunoglobulin Immunoglobulin Framework Regions Ig Framework Region Framework Region, Ig Framework Regions, Ig Ig Framework Regions Immunoglobulin Framework Region

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Immunoglobulin Variable Region [D12.776.124.486.485.797]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Immunoglobulin Variable Region [D12.776.124.790.651.797]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Immunoglobulin Variable Region [D12.776.377.715.548.797]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Immunoglobulin Variable Region [G02.111.570.060.425]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Variable Region".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	2	2
1999	0	1	1
2002	0	1	1
2005	0	3	3
2009	0	1	1
2013	2	0	2

Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.

Watson CT, Steinberg KM, Huddleston J, Warren RL, Malig M, Schein J, Willsey AJ, Joy JB, Scott JK, Graves TA, Wilson RK, Holt RA, Eichler EE, Breden F. Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. Am J Hum Genet. 2013 Apr 04; 92(4):530-46.

View in: PubMed
Fu M, Brewer S, Olafsen T, Wu AM, Gordon LK, Said J, Braun J, Wadehra M. Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol. 2013 Feb; 15(1):68-78.

View in: PubMed
Freeman JD, Warren RL, Webb JR, Nelson BH, Holt RA. Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res. 2009 Oct; 19(10):1817-24.

View in: PubMed
Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005 Oct 27; 353(17):1793-801.

View in: PubMed
Zhou J, Saleque S, Ermakova O, Sepulveda MA, Yang Q, Eckhardt LA, Schildkraut CL, Birshtein BK. Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line. J Immunol. 2005 Aug 15; 175(4):2317-20.

View in: PubMed
Klimstra WB, Williams JC, Ryman KD, Heidner HW. Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. Virology. 2005 Jul 20; 338(1):9-21.

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Yoshida S, Kobayashi T, Matsuoka H, Seki C, Gosnell WL, Chang SP, Ishii A. T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood. 2003 Mar 15; 101(6):2300-6.

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Bynoe MS, Spatz L, Diamond B. Characterization of anti-DNA B cells that escape negative selection. Eur J Immunol. 1999 04; 29(4):1304-13.

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Kostense S, Raaphorst FM, Notermans DW, Joling J, Hooibrink B, Pakker NG, Danner SA, Teale JM, Miedema F. Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during highly active antiretroviral therapy. AIDS. 1998 Dec 24; 12(18):F235-40.

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Gokmen E, Raaphorst FM, Boldt DH, Teale JM. Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization. Blood. 1998 Oct 15; 92(8):2802-14.

View in: PubMed

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