Complementarity Determining Regions

"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).

Descriptor ID	D022801
MeSH Number(s)	D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
Concept/Terms	Complementarity Determining Regions Complementarity Determining Regions Region, Complementarity Determining Regions, Complementarity Determining Hypervariable Regions, Immunoglobulin Hypervariable Region, Immunoglobulin Immunoglobulin Hypervariable Region Immunoglobulin Hypervariable Regions Region, Immunoglobulin Hypervariable Regions, Immunoglobulin Hypervariable Complementarity Determining Region Complementarity-Determining Region Complementarity-Determining Regions Regions, Complementarity-Determining Complementarity Determining Region 3 Complementarity Determining Region 3 Complementarity-Determining Region 3 Complementarity-Determining Region 3s Third Complementarity-Determining Region Complementarity-Determining Region, Third Complementarity-Determining Regions, Third Third Complementarity Determining Region Third Complementarity-Determining Regions Complementarity Determining Region III Complementarity Determining Region 1 Complementarity Determining Region 1 Complementarity Determining Region I Complementarity Determining Region 2 Complementarity Determining Region 2 Complementarity Determining Region II

Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Complementarity Determining Regions [D12.644.541.500.650.500.180]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.486.485.797]
Complementarity Determining Regions [D12.776.124.486.485.797.180]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.790.651.797]
Complementarity Determining Regions [D12.776.124.790.651.797.180]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
Immunoglobulin Variable Region [D12.776.377.715.548.797]
Complementarity Determining Regions [D12.776.377.715.548.797.180]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Antigen [D12.776.543.750.705.816]
Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
Complementarity Determining Regions [D12.776.543.750.705.816.824.300]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Immunoglobulin Variable Region [G02.111.570.060.425]
Complementarity Determining Regions [G02.111.570.060.425.160]

Below are MeSH descriptors whose meaning is related to "Complementarity Determining Regions".

Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 1998 and 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	0	2
2001	1	1	2
2002	0	1	1
2012	0	1	1
2016	0	1	1
2022	0	1	1

Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.

Jaffe DB, Shahi P, Adams BA, Chrisman AM, Finnegan PM, Raman N, Royall AE, Tsai F, Vollbrecht T, Reyes DS, Hepler NL, McDonnell WJ. Functional antibodies exhibit light chain coherence. Nature. 2022 Nov; 611(7935):352-357.

View in: PubMed
IJspeert H, Rozmus J, Schwarz K, Warren RL, van Zessen D, Holt RA, Pico-Knijnenburg I, Simons E, Jerchel I, Wawer A, Lorenz M, Patiroglu T, Akar HH, Leite R, Verkaik NS, Stubbs AP, van Gent DC, van Dongen JJ, van der Burg M. XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination. Blood. 2016 08 04; 128(5):650-9.

View in: PubMed
Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 2012 Sep 27; 489(7417):526-32.

View in: PubMed
Ebhardt MB, Shive CL, Guardia R, Gapin L, Boehm BO, Forsthuber TG. Immunological adjuvants efficiently induce antigen-specific T cell responses in old mice: implications for vaccine adjuvant development in aged individuals. Cell Immunol. 2002 Jan; 215(1):87-97.

View in: PubMed
Kostense S, Raaphorst FM, Joling J, Notermans DW, Prins JM, Danner SA, Reiss P, Lange JM, Teale JM, Miedema F. T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: effect of antiretroviral therapy. AIDS. 2001 Jun 15; 15(9):1097-107.

View in: PubMed
Gokmen E, Bachier C, Raaphorst FM, Muller T, Armstrong D, LeMaistre CF, Teale JM. Ig heavy chain CDR3 size diversities are similar after conventional peripheral blood and ex vivo expanded hematopoietic cell transplants. Bone Marrow Transplant. 2001 Feb; 27(4):413-24.

View in: PubMed
Kostense S, Raaphorst FM, Notermans DW, Joling J, Hooibrink B, Pakker NG, Danner SA, Teale JM, Miedema F. Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during highly active antiretroviral therapy. AIDS. 1998 Dec 24; 12(18):F235-40.

View in: PubMed
Raaphorst FM, Gokmen E, Teale JM. Analysis of clonal diversity in mouse immunoglobulin heavy chain genes selected for size of the antigen combining site. Immunol Invest. 1998 Dec; 27(6):355-65.

View in: PubMed

People

Explore

Similar Concepts

Top Journals