"Poly(A)-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.
| Descriptor ID |
D039102
|
| MeSH Number(s) |
D12.776.157.725.452 D12.776.664.962.452
|
| Concept/Terms |
Poly(A)-Binding Proteins- Poly(A)-Binding Proteins
- Poly(A)-Binding Protein
- Poly A-Binding Proteins
- Poly A Binding Proteins
- Poly(A)+ mRNA Binding Protein
- Poly A-Binding Protein
- Poly A Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Poly(A)-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Poly(A)-Binding Proteins".
This graph shows the total number of publications written about "Poly(A)-Binding Proteins" by people in this website by year, and whether "Poly(A)-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Poly(A)-Binding Proteins" by people in Profiles.
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Gu Y, Wei X, Sun Y, Gao H, Zheng X, Wong LL, Jin L, Liu N, Hernandez B, Peplowska K, Zhao X, Zhan QM, Feng XH, Tang ZY, Ji J. miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. Cancer Res. 2019 03 01; 79(5):941-953.
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Khan MA, Goss DJ. Poly (A) binding protein enhances the binding affinity of potyvirus VPg to eukaryotic initiation factor eIF4F and activates in vitro translation. Int J Biol Macromol. 2019 Jan; 121:947-955.
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Gonz?lez-Feliciano JA, Hern?ndez-P?rez M, Estrella LA, Col?n-L?pez DD, L?pez A, Mart?nez M, Maur?s-Rivera KR, Lasalde C, Mart?nez D, Araujo-P?rez F, Gonz?lez CI. The role of HuR in the post-transcriptional regulation of interleukin-3 in T cells. PLoS One. 2014; 9(3):e92457.
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Goss DJ, Kleiman FE. Poly(A) binding proteins: are they all created equal? Wiley Interdiscip Rev RNA. 2013 Mar-Apr; 4(2):167-79.
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Khan MA, Goss DJ. Poly(A)-binding protein increases the binding affinity and kinetic rates of interaction of viral protein linked to genome with translation initiation factors eIFiso4F and eIFiso4F?4B complex. Biochemistry. 2012 Feb 21; 51(7):1388-95.
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Yumak H, Khan MA, Goss DJ. Poly(A) tail affects equilibrium and thermodynamic behavior of tobacco etch virus mRNA with translation initiation factors eIF4F, eIF4B and PABP. Biochim Biophys Acta. 2010 Sep; 1799(9):653-8.
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Estrella LA, Wilkinson MF, Gonz?lez CI. The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae. J Mol Biol. 2009 Dec 04; 394(3):410-22.
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Cheng S, Sultana S, Goss DJ, Gallie DR. Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc. J Biol Chem. 2008 Dec 26; 283(52):36140-53.
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Khan MA, Yumak H, Gallie DR, Goss DJ. Effects of poly(A)-binding protein on the interactions of translation initiation factor eIF4F and eIF4F.4B with internal ribosome entry site (IRES) of tobacco etch virus RNA. Biochim Biophys Acta. 2008 Oct; 1779(10):622-7.
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Khan MA, Goss DJ. Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP. Biochemistry. 2005 Mar 22; 44(11):4510-6.