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Sabzali Javadov

TitlePhD
Faculty RankProfessor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus
San Juan PR 936
Phone7877582525 ext.2909
Fax7877530120
ORCID ORCID Icon0000-0002-7024-5383 Additional info
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    Collapse Biography 
    Collapse education and training
    Medical University, Moscow, RussiaM.D.1983Medical Biochemistry
    Cardiology Research Center, Moscow, RussiaPh.D.1986Biochemistry & Cardiology
    Cardiology Research Center, Moscow, RussiaD.Sc.1992Biochemistry & Cardiology
    Medical Academy, Magdeburg, GermanyPostdoc1987Biochemistry
    Institute of Cardiology , Budapest, HungaryPostdoc1990Biochemistry & Cardiology
    University of Bristol, Bristol, EnglandVisiting Professor2001Biochemistry & Cardiology

    Collapse Overview 
    Collapse overview
    I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.
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    Collapse Research 
    Collapse research activities and funding
    2006477     (Sabzali Javadov)
    NSF
    Biophysical multiscale modeling of mitochondrial swelling
    SC1GM128210     (Sabzali Javadov)
    NIH
    Crosstalk between mitochondrial permeability transition and ETC supercomplexes.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kozlov AV, Javadov S, Sommer N. Cellular ROS and Antioxidants: Physiological and Pathological Role. Antioxidants (Basel). 2024 May 14; 13(5). PMID: 38790707.
      Citations:    
    2. Zivari-Ghader T, Valioglu F, Eftekhari A, Aliyeva I, Beylerli O, Davran S, Cho WC, Beilerli A, Khalilov R, Javadov S. Recent progresses in natural based therapeutic materials for Alzheimer's disease. Heliyon. 2024 Feb 29; 10(4):e26351. PMID: 38434059.
      Citations:    
    3. Chapa-Dubocq XR, Rodr?guez-Graciani KM, Garc?a-B?ez J, Vadovsky A, Bazil JN, Javadov S. The Role of Swelling in the Regulation of OPA1-Mediated Mitochondrial Function in the Heart In Vitro. Cells. 2023 08 08; 12(16). PMID: 37626827.
      Citations:    Fields:    Translation:HumansCells
    4. Chapa-Dubocq XR, Rodr?guez-Graciani KM, Escobales N, Javadov S. Mitochondrial Volume Regulation and Swelling Mechanisms in Cardiomyocytes. Antioxidants (Basel). 2023 Jul 28; 12(8). PMID: 37627512.
      Citations:    
    5. Elia A, Parodi-Rullan R, Vazquez-Torres R, Carey A, Javadov S, Fossati S. Amyloid ? induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer's disease model. bioRxiv. 2023 Jul 11. PMID: 37502936.
      Citations:    
    6. Jang S, Javadov S. Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains. Redox Biol. 2023 08; 64:102774. PMID: 37300954.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Jang S, Chorna N, Rodr?guez-Graciani KM, Inyushin M, Fossati S, Javadov S. The Effects of Amyloid-? on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells. J Alzheimers Dis. 2023; 93(1):307-319. PMID: 36970904.
      Citations: 2     Fields:    Translation:HumansCells
    8. Chapa-Dubocq XR, Garcia-Baez JF, Bazil JN, Javadov S. Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches. Cell Biol Toxicol. 2023 04; 39(2):435-450. PMID: 35606662.
      Citations: 3     Fields:    Translation:Cells
    9. Kuznetsov AV, Javadov S, Margreiter R, Hagenbuchner J, Ausserlechner MJ. Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles. Int J Mol Sci. 2022 Feb 18; 23(4). PMID: 35216368.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Rodr?guez-Graciani KM, Chapa-Dubocq XR, Ayala-Arroyo EJ, Chaves-Negr?n I, Jang S, Chorna N, S Maskrey T, Wipf P, Javadov S. Effects of Ferroptosis on the Metabolome in Cardiac Cells: The Role of Glutaminolysis. Antioxidants (Basel). 2022 Jan 29; 11(2). PMID: 35204160.
      Citations:    
    11. Jang S, Chapa-Dubocq XR, Parodi-Rull?n RM, Fossati S, Javadov S. Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells. Cells. 2022 01 22; 11(3). PMID: 35159183.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Javadov S. Mitochondria and ferroptosis. Curr Opin Physiol. 2022 Feb; 25. PMID: 35342847.
      Citations:    
    13. Jang S, Chapa-Dubocq XR, Fossati S, Javadov S. Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria. Front Physiol. 2021; 12:773839. PMID: 34950052.
      Citations:    
    14. Parodi-Rull?n RM, Javadov S, Fossati S. Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Cells. 2021 10 27; 10(11). PMID: 34831125.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    15. Jang S, Chapa-Dubocq XR, Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA, Bayir H, Kagan VE, Javadov S. Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes. Redox Biol. 2021 09; 45:102021. PMID: 34102574.
      Citations: 58     Fields:    Translation:Cells
    16. Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS, Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayir H. Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS). Angew Chem Int Ed Engl. 2021 05 17; 60(21):11784-11788. PMID: 33684237.
      Citations: 19     Fields:    Translation:AnimalsCells
    17. Kuznetsov AV, Javadov S, Margreiter R, Grimm M, Hagenbuchner J, Ausserlechner MJ. Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation. Biochim Biophys Acta Bioenerg. 2021 06 01; 1862(6):148393. PMID: 33549532.
      Citations: 5     Fields:    Translation:HumansCells
    18. Javadov S, Jang S, Chapa-Dubocq XR, Khuchua Z, Camara AK. Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role. J Mol Med (Berl). 2021 01; 99(1):57-73. PMID: 33201259.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    19. Rodr?guez-Graciani KM, Chapa-Dubocq XR, MacMillan-Crow LA, Javadov S. Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats. Cell Physiol Biochem. 2020 Oct 30; 54(6):1101-1114. PMID: 33119220.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Javadov S, Kozlov AV, Camara AKS. Mitochondria in Health and Diseases. Cells. 2020 05 09; 9(5). PMID: 32397376.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    21. Chapa-Dubocq XR, Rodr?guez-Graciani KM, Guzm?n-Hern?ndez RA, Jang S, Brookes PS, Javadov S. Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes. Int J Mol Sci. 2020 Feb 25; 21(5). PMID: 32106430.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Kuznetsov AV, Javadov S, Grimm M, Margreiter R, Ausserlechner MJ, Hagenbuchner J. Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells. Cells. 2020 01 16; 9(1). PMID: 31963121.
      Citations: 29     Fields:    Translation:HumansCells
    23. Sabzali Javadov, Andrey V. Kozlov & Amadou K.S. Camara (Eds.). Mitochondria in Health and Diseases. 2020; 434p. View Publication.
    24. Jang S, Javadov S. OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling. Mitochondrion. 2020 03; 51:30-39. PMID: 31870826.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    25. Makarov VI, Khmelinskii I, Khuchua Z, Javadov S. In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity. Mitochondrion. 2020 01; 50:71-81. PMID: 31669621.
      Citations: 5     Fields:    Translation:AnimalsCells
    26. M Parodi-Rull?n R, Chapa-Dubocq X, Guzm?n-Hern?ndez R, Jang S, A Torres-Ramos C, Ayala-Pe?a S, Javadov S. The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells. Cells. 2019 10 13; 8(10). PMID: 31614941.
      Citations: 7     Fields:    Translation:AnimalsCells
    27. Kuznetsov AV, Javadov S, Margreiter R, Grimm M, Hagenbuchner J, Ausserlechner MJ. The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury. Antioxidants (Basel). 2019 Oct 06; 8(10). PMID: 31590423.
      Citations:    
    28. Escobales N, Nu?ez RE, Javadov S. Mitochondrial angiotensin receptors and cardioprotective pathways. Am J Physiol Heart Circ Physiol. 2019 06 01; 316(6):H1426-H1438. PMID: 30978131.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    29. Jang S, Javadov S. Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria. Sci Rep. 2018 12 07; 8(1):17732. PMID: 30531981.
      Citations: 29     Fields:    Translation:AnimalsCells
    30. Khuchua Z, Glukhov AI, Strauss AW, Javadov S. Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases. Int J Mol Sci. 2018 Nov 04; 19(11). PMID: 30400386.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    31. Parodi-Rull?n RM, Soto-Prado J, Vega-Lugo J, Chapa-Dubocq X, D?az-Cordero SI, Javadov S. Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction. Cell Physiol Biochem. 2018; 50(1):288-303. PMID: 30282073.
      Citations: 12     Fields:    Translation:AnimalsCells
    32. Parodi-Rull?n RM, Chapa-Dubocq XR, Javadov S. Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3. Front Physiol. 2018; 9:1094. PMID: 30131726.
      Citations:    
    33. Nu?ez RE, Javadov S, Escobales N. Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts. Pflugers Arch. 2018 09; 470(9):1391-1403. PMID: 29748710.
      Citations: 5     Fields:    Translation:AnimalsCells
    34. Schafer C, Moore V, Dasgupta N, Javadov S, James JF, Glukhov AI, Strauss AW, Khuchua Z. The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice. Front Pharmacol. 2018; 9:318. PMID: 29695963.
      Citations:    
    35. Makarov VI, Khmelinskii I, Javadov S. Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach. Molecules. 2018 Mar 28; 23(4). PMID: 29597314.
      Citations: 6     Fields:    Translation:HumansCells
    36. Jang S, Javadov S. Current Challenges in Elucidating Respiratory Supercomplexes in Mitochondria: Methodological Obstacles. Front Physiol. 2018; 9:238. PMID: 29615931.
      Citations:    
    37. Chapa-Dubocq X, Makarov V, Javadov S. Simple kinetic model of mitochondrial swelling in cardiac cells. J Cell Physiol. 2018 07; 233(7):5310-5321. PMID: 29215716.
      Citations: 20     Fields:    Translation:AnimalsCells
    38. Nu?ez RE, Javadov S, Escobales N. Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria. Clin Exp Pharmacol Physiol. 2017 Dec; 44(12):1201-1212. PMID: 28707739.
      Citations: 7     Fields:    Translation:AnimalsCells
    39. Javadov S, Chapa-Dubocq X, Makarov V. Different approaches to modeling analysis of mitochondrial swelling. Mitochondrion. 2018 01; 38:58-70. PMID: 28802667.
      Citations: 54     Fields:    Translation:HumansCells
    40. Jang S, Javadov S. Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria. Arch Biochem Biophys. 2017 09 15; 630:1-8. PMID: 28736227.
      Citations: 24     Fields:    Translation:AnimalsCells
    41. Parodi-Rull?n RM, Chapa-Dubocq X, Rull?n PJ, Jang S, Javadov S. High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities. Front Pharmacol. 2017; 8:275. PMID: 28559847.
      Citations:    
    42. Javadov S, Jang S, Parodi-Rull?n R, Khuchua Z, Kuznetsov AV. Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection? Cell Mol Life Sci. 2017 08; 74(15):2795-2813. PMID: 28378042.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    43. Huang Y, Powers C, Moore V, Schafer C, Ren M, Phoon CK, James JF, Glukhov AV, Javadov S, Vaz FM, Jefferies JL, Strauss AW, Khuchua Z. The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome. Orphanet J Rare Dis. 2017 03 09; 12(1):49. PMID: 28279226.
      Citations: 28     Fields:    Translation:Animals
    44. Kuznetsov AV, Javadov S, Saks V, Margreiter R, Grimm M. Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells. Biochim Biophys Acta Bioenerg. 2017 Jun; 1858(6):418-431. PMID: 28279675.
      Citations: 19     Fields:    Translation:HumansCells
    45. Jang S, Lewis TS, Powers C, Khuchua Z, Baines CP, Wipf P, Javadov S. Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion. Antioxid Redox Signal. 2017 07 01; 27(1):57-69. PMID: 27604998.
      Citations: 53     Fields:    Translation:AnimalsCells
    46. Rodr?Guez-Reyes N, Rodr?Guez-Zayas AE, Javadov S, Frontera WR. Single muscle fiber contractile properties in diabetic RAT muscle. Muscle Nerve. 2016 06; 53(6):958-64. PMID: 26598963.
      Citations: 1     Fields:    Translation:AnimalsCells
    47. Javadov S, Jang S, Rodriguez-Reyes N, Rodriguez-Zayas AE, Soto Hernandez J, Krainz T, Wipf P, Frontera W. Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats. Oncotarget. 2015 Nov 24; 6(37):39469-81. PMID: 26415224.
      Citations: 37     Fields:    Translation:AnimalsCells
    48. Huang Y, Powers C, Madala SK, Greis KD, Haffey WD, Towbin JA, Purevjav E, Javadov S, Strauss AW, Khuchua Z. Cardiac metabolic pathways affected in the mouse model of barth syndrome. PLoS One. 2015; 10(6):e0128561. PMID: 26030409.
      Citations: 40     Fields:    Translation:AnimalsCells
    49. Santacana G, Javadov S. Fifth Annual Meeting of the Puerto Rico Physiological Society. Physiologist. 2015 May; 58(3):132-4. PMID: 26390715.
      Citations:    Fields:    Translation:Humans
    50. Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG. Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol. 2015 May; 34(5):316-26. PMID: 25849439.
      Citations: 19     Fields:    Translation:AnimalsCells
    51. Javadov S. The calcium-ROS-pH triangle and mitochondrial permeability transition: challenges to mimic cardiac ischemia-reperfusion. Front Physiol. 2015; 6:83. PMID: 25852570.
      Citations:    
    52. Barreto-Torres G, Hernandez JS, Jang S, Rodr?guez-Mu?oz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr 01; 308(7):H749-58. PMID: 25617357.
      Citations: 38     Fields:    Translation:AnimalsCells
    53. Javadov S, Escobales N. The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion. J Pharm Pharm Sci. 2015; 18(3):547-50. PMID: 26517140.
      Citations: 3     Fields:    Translation:HumansAnimals
    54. Jang S, Javadov S. Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. PLoS One. 2014; 9(11):e113526. PMID: 25423094.
      Citations: 18     Fields:    Translation:AnimalsCells
    55. Kuznetsov AV, Javadov S, Sickinger S, Frotschnig S, Grimm M. H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochim Biophys Acta. 2015 Feb; 1853(2):276-84. PMID: 25450968.
      Citations: 97     Fields:    Translation:AnimalsCells
    56. Escobales N, Nu?ez RE, Jang S, Parodi-Rullan R, Ayala-Pe?a S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. J Mol Cell Cardiol. 2014 Dec; 77:136-46. PMID: 25451170.
      Citations: 50     Fields:    Translation:AnimalsCells
    57. Nu?ez RE, Castro M, Javadov S, Escobales N. Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. J Cardiovasc Pharmacol. 2014 Aug; 64(2):172-9. PMID: 24705171.
      Citations: 8     Fields:    Translation:AnimalsCells
    58. Javadov S, Jang S, Agostini B. Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives. Pharmacol Ther. 2014 Nov; 144(2):202-25. PMID: 24924700.
      Citations: 73     Fields:    Translation:HumansCells
    59. Javadov S. Letter to the editor: "cyclosporin A in left ventricular remodeling after myocardial infarction". Am J Physiol Heart Circ Physiol. 2014 Mar 01; 306(5):H777. PMID: 24583825.
      Citations: 1     Fields:    Translation:Animals
    60. Hern?ndez JS, Barreto-Torres G, Kuznetsov AV, Khuchua Z, Javadov S. Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria. J Cell Mol Med. 2014 Apr; 18(4):709-20. PMID: 24444314.
      Citations: 46     Fields:    Translation:AnimalsCells
    61. Sabzali Javadov & Andrey V. Kuznetsov (Eds.) . Mitochondria: the cell powerhouse and nexus of stress. 2014; 121p. View Publication.
    62. Xiong D, He H, James J, Tokunaga C, Powers C, Huang Y, Osinska H, Towbin JA, Purevjav E, Balschi JA, Javadov S, McGowan FX, Strauss AW, Khuchua Z. Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H326-38. PMID: 24285112.
      Citations: 24     Fields:    Translation:AnimalsCells
    63. Javadov S, Kuznetsov AV. Mitochondria: the cell powerhouse and nexus of stress. Front Physiol. 2013; 4:207. PMID: 23966947.
      Citations:    
    64. Kuznetsov AV, Javadov S, Guzun R, Grimm M, Saks V. Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II. Front Physiol. 2013; 4:82. PMID: 23630499.
      Citations:    
    65. Javadov S, Kuznetsov A. Mitochondrial permeability transition and cell death: the role of cyclophilin d. Front Physiol. 2013; 4:76. PMID: 23596421.
      Citations:    
    66. Barreto-Torres G, Parodi-Rull?n R, Javadov S. The role of PPARa in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats. Int J Mol Sci. 2012; 13(6):7694-7709. PMID: 22837722.
      Citations: 31     Fields:    Translation:AnimalsCells
    67. Parodi-Rullan R, Barreto-Torres G, Ruiz L, Casasnovas J, Javadov S. Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats. Cell Physiol Biochem. 2012; 29(5-6):841-50. PMID: 22613984.
      Citations: 25     Fields:    Translation:AnimalsCells
    68. Rajapurohitam V, Kilic A, Javadov S, Karmazyn M. Role of NF-?B and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy. Mol Cell Biochem. 2012 Jul; 366(1-2):287-97. PMID: 22527934.
      Citations: 8     Fields:    Translation:AnimalsCells
    69. Gan XT, Hunter JC, Huang C, Xue J, Rajapurohitam V, Javadov S, Karmazyn M. Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation. Mol Cell Biochem. 2012 Apr; 363(1-2):323-33. PMID: 22160804.
      Citations: 3     Fields:    Translation:AnimalsCells
    70. Javadov S, Hunter JC, Barreto-Torres G, Parodi-Rullan R. Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis. Cell Physiol Biochem. 2011; 27(3-4):179-90. PMID: 21471706.
      Citations: 19     Fields:    Translation:HumansCells
    71. Zeidan A, Hunter JC, Javadov S, Karmazyn M. mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy. Mol Cell Biochem. 2011 Jun; 352(1-2):99-108. PMID: 21318349.
      Citations: 19     Fields:    Translation:AnimalsCells
    72. Javadov S, Rajapurohitam V, Kilic A, Hunter JC, Zeidan A, Said Faruq N, Escobales N, Karmazyn M. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Basic Res Cardiol. 2011 Jan; 106(1):99-109. PMID: 20886221.
      Citations: 51     Fields:    Translation:AnimalsCells
    73. Hunter JC, Zeidan A, Javadov S, Kilic A, Rajapurohitam V, Karmazyn M. Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway. J Mol Cell Cardiol. 2009 Dec; 47(6):810-8. PMID: 19799911.
      Citations: 17     Fields:    Translation:AnimalsCells
    74. Javadov S, Karmazyn M, Escobales N. Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases. J Pharmacol Exp Ther. 2009 Sep; 330(3):670-8. PMID: 19509316.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    75. Javadov S, Rajapurohitam V, Kilic A, Zeidan A, Choi A, Karmazyn M. Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. J Mol Cell Cardiol. 2009 Jun; 46(6):998-1007. PMID: 19318234.
      Citations: 27     Fields:    Translation:AnimalsCells
    76. Kilic A, Javadov S, Karmazyn M. Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy. J Mol Cell Cardiol. 2009 Mar; 46(3):360-9. PMID: 19111554.
      Citations: 21     Fields:    Translation:AnimalsCells
    77. Karmazyn M, Kilic A, Javadov S. The role of NHE-1 in myocardial hypertrophy and remodelling. J Mol Cell Cardiol. 2008 Apr; 44(4):647-53. PMID: 18329039.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    78. Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M. NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovasc Res. 2008 Jan 15; 77(2):416-24. PMID: 18006455.
      Citations: 36     Fields:    Translation:AnimalsCells
    79. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M. Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res. 2008 Jan; 77(1):64-72. PMID: 18006472.
      Citations: 40     Fields:    Translation:AnimalsCells
    80. Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S, Karmazyn M. Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways. J Pharmacol Exp Ther. 2007 Sep; 322(3):1110-6. PMID: 17562852.
      Citations: 19     Fields:    Translation:AnimalsCells
    81. Javadov S, Karmazyn M. Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem. 2007; 20(1-4):1-22. PMID: 17595511.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    82. Xia Y, Javadov S, Gan TX, Pang T, Cook MA, Karmazyn M. Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes. J Pharmacol Exp Ther. 2007 Jan; 320(1):14-21. PMID: 17012605.
      Citations: 7     Fields:    Translation:AnimalsCells
    83. Zeidan A, Javadov S, Karmazyn M. Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes. Cardiovasc Res. 2006 Oct 01; 72(1):101-11. PMID: 16901475.
      Citations: 39     Fields:    Translation:AnimalsCells
    84. Rajapurohitam V, Javadov S, Purdham DM, Kirshenbaum LA, Karmazyn M. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1. J Mol Cell Cardiol. 2006 Aug; 41(2):265-74. PMID: 16806260.
      Citations: 37     Fields:    Translation:AnimalsCells
    85. Javadov S, Purdham DM, Zeidan A, Karmazyn M. NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1722-30. PMID: 16679399.
      Citations: 23     Fields:    Translation:AnimalsCells
    86. Javadov S, Baetz D, Rajapurohitam V, Zeidan A, Kirshenbaum LA, Karmazyn M. Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species. J Pharmacol Exp Ther. 2006 Jun; 317(3):1036-43. PMID: 16513848.
      Citations: 27     Fields:    Translation:AnimalsCells
    87. Zeidan A, Purdham DM, Rajapurohitam V, Javadov S, Chakrabarti S, Karmazyn M. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J Pharmacol Exp Ther. 2005 Dec; 315(3):1075-84. PMID: 16144973.
      Citations: 34     Fields:    Translation:AnimalsCells
    88. Javadov S, Huang C, Kirshenbaum L, Karmazyn M. NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat. J Mol Cell Cardiol. 2005 Jan; 38(1):135-43. PMID: 15623430.
      Citations: 24     Fields:    Translation:AnimalsCells
    89. Alekperova GA, Orudzhev AG, Javadov SA. Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia. Biochemistry (Mosc). 2004 Jul; 69(7):748-53. PMID: 15310273.
      Citations: 2     Fields:    Translation:HumansCells
    90. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. Cardiovasc Res. 2004 Feb 15; 61(3):372-85. PMID: 14962470.
      Citations: 364     Fields:    Translation:HumansCells
    91. Javadov SA, Clarke S, Das M, Griffiths EJ, Lim KH, Halestrap AP. Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart. J Physiol. 2003 Jun 01; 549(Pt 2):513-24. PMID: 12692185.
      Citations: 101     Fields:    Translation:AnimalsCells
    92. Orudzhev AG, Guseinova EE, Khalilova IS, Dzhavadov SA. [Assessment of endogenous intoxication and thrombocyte functions in beta-thalassemia]. Klin Lab Diagn. 2003 Mar; (3):39-41. PMID: 12715396.
      Citations: 1     Fields:    Translation:HumansCells
    93. Lim KH, Javadov SA, Das M, Clarke SJ, Suleiman MS, Halestrap AP. The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration. J Physiol. 2002 12 15; 545(3):961-74. PMID: 12482899.
      Citations: 73     Fields:    Translation:AnimalsCells
    94. Javadov SA, Lim KH, Kerr PM, Suleiman MS, Angelini GD, Halestrap AP. Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition. Cardiovasc Res. 2000 Jan 14; 45(2):360-9. PMID: 10728356.
      Citations: 56     Fields:    Translation:AnimalsCells
    95. Dzhavadov SA. [Relation between mitochondrial respiratory function and postischemic recovery of the isolated heart contractility]. Biull Eksp Biol Med. 1998 Nov; 126(11):538-41. PMID: 9883363.
      Citations:    Fields:    Translation:AnimalsCells
    96. Halestrap AP, Kerr PM, Javadov S, Woodfield KY. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):79-94. PMID: 9714750.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    97. Lebedeva LG, Aleksandrova SS, Kiselar' ZhG, Kirsanova ID, Dzhavadov SA, Basnak'ian AG, Votrin II. [Study of the spectrum of rabbit myocardium nuclear DNAases using models of ischemia and diabetes mellitus]. Vopr Med Khim. 1995 Jul-Aug; 41(4):2-4. PMID: 8571579.
      Citations:    Fields:    Translation:AnimalsCells
    98. Lebedeva LG, Aleksandrova SS, Kirsanova ID, Basnak'ian AG, Dzhavadov SA, Votrin II. [Nuclear endo-DNAse from rabbit myocardium in ischemia and diabetes mellitus]. Vopr Med Khim. 1995 May-Jun; 41(3):9-11. PMID: 8585187.
      Citations:    Fields:    Translation:AnimalsCells
    99. Dzhavadov SA, Dzhokharidze TZ, Dzhaliashvili IV, Gel'fgat EB, Saks VA, Pogacha G. [Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion]. Biokhimiia. 1992 Dec; 57(12):1917-29. PMID: 1294259.
      Citations: 1     Fields:    Translation:AnimalsCells
    100. Kuznetsov AV, Veksler VI, Sharov VG, Dzhavadov SA, Saks VA. [Quantitative relationship between ischemic heart disease and parameters of energy metabolism]. Vestn Ross Akad Med Nauk. 1992; (3):21-6. PMID: 1382753.
      Citations:    Fields:    Translation:AnimalsCells
    101. Saks VA, Kapelko VI, Kupriyanov VV, Kuznetsov AV, Lakomkin VL, Veksler VI, Sharov VG, Javadov SA, Seppet EK, Kairane C. Quantitative evaluation of relationship between cardiac energy metabolism and post-ischemic recovery of contractile function. J Mol Cell Cardiol. 1989 Feb; 21 Suppl 1:67-78. PMID: 2733031.
      Citations: 15     Fields:    Translation:AnimalsCells
    102. Sharov VG, Saks VA, Kupriyanov VV, Lakomkin VL, Kapelko VI, Javadov SA. Protection of ischemic myocardium by exogenous phosphocreatine. I. Morphologic and phosphorus 31-nuclear magnetic resonance studies. J Thorac Cardiovasc Surg. 1987 Nov; 94(5):749-61. PMID: 3669703.
      Citations: 14     Fields:    Translation:Animals
    103. Seppet EK, Kallikorm AP, Dzhavadov SA, Preobrazhenskii AN, Lakomkin VA. [Energy-related disorders of myocardial contractility in calcium overload of the cardiomyocytes]. Kardiologiia. 1987 Jul; 27(7):72-6. PMID: 3656923.
      Citations: 1     Fields:    Translation:AnimalsCells
    104. Anyukhovsky EP, Javadov SA, Preobrazhensky AN, Beloshapko GG, Rosenshtraukh LV, Saks VA. Effect of phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart. Biochem Med Metab Biol. 1986 Jun; 35(3):327-34. PMID: 3718764.
      Citations: 6     Fields:    Translation:Animals
    105. Preobrazhenskii AN, Dzhavadov SA, Saks VA. [Possible mechanism of the protective effect of phosphocreatine on the ischemic myocardium]. Biokhimiia. 1986 Apr; 51(4):675-83. PMID: 3011127.
      Citations: 2     Fields:    Translation:AnimalsCells
    106. Dzhavadov SA, Preobrazhenskii AN, Saks VA. [Effect of phosphocreatine on the lysophosphoglyceride levels in total ischemia of the rat myocardium]. Biokhimiia. 1986 Apr; 51(4):668-74. PMID: 3708016.
      Citations:    Fields:    Translation:AnimalsCells
    107. Dzhavadov SA, Preobrazhenskii AN, Lakomkin VL, Kupriianov VV, Saks VA. [Various aspects of protective effect of exogenous phosphocreatine on the ischemic myocardium]. Vestn Akad Med Nauk SSSR. 1986; (12):58-67. PMID: 3825277.
      Citations:    Fields:    Translation:Animals
    108. Aniukhovskii EP, Dzhavadov SA, Preobrazhenskii AN, Beloshapko GG, Rozenshtraukh LV. [Effect of phosphocreatine and phosphocreatinine on membrane phospholipid metabolism in acute myocardial ischemia]. Kardiologiia. 1985 Aug; 25(8):64-8. PMID: 4068466.
      Citations:    Fields:    Translation:Animals
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