Proteasome Endopeptidase Complex

"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Descriptor ID	D046988
MeSH Number(s)	D05.500.562.500 D08.811.277.656.918 D08.811.600.730
Concept/Terms	Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex Complex, Proteasome Endopeptidase Endopeptidase Complex, Proteasome Macropain Macroxyproteinase Multicatalytic Proteinase Proteinase, Multicatalytic Prosome Proteasome 20S Proteasome Proteasome, 20S Multicatalytic Endopeptidase Complex Complex, Multicatalytic Endopeptidase Endopeptidase Complex, Multicatalytic Ingensin Ingensin

Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Proteasome Endopeptidase Complex [D05.500.562.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Proteasome Endopeptidase Complex [D08.811.277.656.918]
Multienzyme Complexes [D08.811.600]
Proteasome Endopeptidase Complex [D08.811.600.730]

Below are MeSH descriptors whose meaning is related to "Proteasome Endopeptidase Complex".

Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.

Bar chart showing 91 publications over 28 distinct years, with a maximum of 8 publications in 2009 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	1	1
1999	2	1	3
2000	0	3	3
2001	0	2	2
2002	0	3	3
2003	0	2	2
2004	2	5	7
2005	1	1	2
2006	2	1	3
2007	4	1	5
2008	1	4	5
2009	4	4	8
2010	3	5	8
2011	3	1	4
2012	4	2	6
2013	2	3	5
2014	0	3	3
2015	1	1	2
2016	1	1	2
2017	0	3	3
2018	1	2	3
2019	1	1	2
2020	1	1	2
2021	1	0	1
2022	1	0	1
2023	0	3	3
2025	1	0	1

Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.

Soni S, Yildiz S, Allen EK, Petersen H, Peeples M, El Zahed S, Rosas L, Anang V, Antonescu L, Nho RS, Mora AL, Horowitz JC, Rojas M, Medina RA, Thomas PG, Garc?a-Sastre A, Tesfaigzi Y, Mebratu YA. BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza. Proc Natl Acad Sci U S A. 2025 Jul 15; 122(28):e2424367122.

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Mebratu YA, Jones JT, Liu C, Negasi ZH, Rahman M, Rojas-Quintero J, O'Connor GT, Gao W, Dupuis J, Cho MH, Litonjua AA, Randell S, Tesfaigzi Y. Bik promotes proteasomal degradation to control low-grade inflammation. J Clin Invest. 2023 12 19; 134(4).

View in: PubMed
Anchoori RK, Anchoori V, Lam B, Tseng SH, Das S, Velasquez FC, Karanam B, Poddatoori D, Patnam R, Rudek MA, Chang YN, Roden RBS. Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor. PLoS One. 2023; 18(6):e0285221.

View in: PubMed
Oliveros G, Wallace CH, Chaudry O, Liu Q, Qiu Y, Xie L, Rockwell P, Figueiredo-Pereira ME, Serrano PA. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain. 2023 03 01; 146(3):898-911.

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Lin VJT, Hu J, Zolekar A, Salick MR, Mittal P, Bird JT, Hoffmann P, Kaykas A, Byrum SD, Wang YC. Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids. Cell Death Dis. 2022 03 24; 13(3):262.

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Chen X, Liao S, Makaros Y, Guo Q, Zhu Z, Krizelman R, Dahan K, Tu X, Yao X, Koren I, Xu C. Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat Chem Biol. 2021 03; 17(3):254-262.

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Mebratu YA, Negasi ZH, Dutta S, Rojas-Quintero J, Tesfaigzi Y. Adaptation of Proteasomes and Lysosomes to Cellular Environments. Cells. 2020 10 01; 9(10).

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Zhang L, Leng TD, Yang T, Li J, Xiong ZG. Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway. Mol Neurobiol. 2020 Nov; 57(11):4754-4766.

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Cheng L, Wu B, Zhang L, Bian E, An R, Yu S, Liu W, Xiong Z. Gankyrin promotes osteosarcoma tumorigenesis by forming a positive feedback loop with YAP. Cell Signal. 2020 01; 65:109460.

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Ha HY, Alfulaij N, Berry MJ, Seale LA. From Selenium Absorption to Selenoprotein Degradation. Biol Trace Elem Res. 2019 Nov; 192(1):26-37.

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