Ubiquitin

"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.

Descriptor ID	D025801
MeSH Number(s)	D12.776.947.500
Concept/Terms	Ubiquitin Ubiquitin ATP-Dependent Proteolysis Factor 1 ATP Dependent Proteolysis Factor 1 HMG-20 APF-1 High Mobility Protein 20 Ubiquitin, Human Ubiquitin, Human Human Ubiquitin

Below are MeSH descriptors whose meaning is more general than "Ubiquitin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Ubiquitins [D12.776.947]
Ubiquitin [D12.776.947.500]

Below are MeSH descriptors whose meaning is related to "Ubiquitin".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.

Bar chart showing 70 publications over 22 distinct years, with a maximum of 8 publications in 2004 and 2006 and 2007 and 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	1	2	3
2003	2	2	4
2004	3	5	8
2005	4	1	5
2006	6	2	8
2007	6	2	8
2008	3	5	8
2009	1	1	2
2010	2	0	2
2012	1	0	1
2013	1	1	2
2015	0	1	1
2016	1	1	2
2017	0	2	2
2018	0	3	3
2019	1	3	4
2020	0	1	1
2021	0	1	1
2022	0	1	1
2023	1	1	2
2024	0	1	1

Below are the most recent publications written about "Ubiquitin" by people in Profiles.

Suryajaya W, Biswas T, Shahabi S, Mealka M, Huxford T, Ghosh G. HDX-MS Analysis of Catalytic Activation of IKK2 in the I?B Kinase Complex. Biochemistry. 2024 09 17; 63(18):2323-2334.

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Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C. Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2023 10 24; 120(43):e2308870120.

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Boghdeh NA, McGraw B, Barrera MD, Anderson C, Baha H, Risner KH, Ogungbe IV, Alem F, Narayanan A. Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses. Viruses. 2023 02 28; 15(3).

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Mekbib T, Suen TC, Rollins-Hairston A, Smith K, Armstrong A, Gray C, Owino S, Baba K, Baggs JE, Ehlen JC, Tosini G, DeBruyne JP. "The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism". PLoS Genet. 2022 07; 18(7):e1010305.

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Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, Haglund E, Suarez JS, Tanji M, Xu R, Takanishi Y, Minaai M, Pastorino S, Morris P, Sakamoto G, Pass HI, Barbour H, Gaudino G, Giorgi C, Pinton P, Onuchic JN, Yang H, Carbone M. BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene ? environment interaction with asbestos. Proc Natl Acad Sci U S A. 2021 11 30; 118(48).

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Zhang L, Leng TD, Yang T, Li J, Xiong ZG. Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway. Mol Neurobiol. 2020 Nov; 57(11):4754-4766.

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Balasubramaniam M, Parcon PA, Bose C, Liu L, Jones RA, Farlow MR, Mrak RE, Barger SW, Griffin WST. Interleukin-1? drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site. J Neuroinflammation. 2019 Dec 27; 16(1):275.

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Zhang B, Han Z, Kumar S, Gupta M, Su WW. Intein-ubiquitin chimeric domain for coordinated protein coexpression. J Biotechnol. 2019 Oct 10; 304:38-43.

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Lai YJ, Zhu BL, Sun F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long Y, Hu XT, He L, Deng XJ, Zhang JH, Yang J, Yan Z, Chen GJ. Estrogen receptor a promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019 08; 18(4):e12961.

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Kobayashi M, Higa JK, Matsui T. The role of ubiquitin in cardiac ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2019 Mar 01; 316(3):H583-H585.

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