"Prostaglandin D2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
| Descriptor ID |
D015230
|
| MeSH Number(s) |
D10.251.355.255.550.200.200 D23.469.050.175.725.200.200
|
| Concept/Terms |
Prostaglandin D2- Prostaglandin D2
- D2, Prostaglandin
- 11-Dehydroprostaglandin F2 alpha
- 11 Dehydroprostaglandin F2 alpha
- F2 alpha, 11-Dehydroprostaglandin
- alpha, 11-Dehydroprostaglandin F2
- PGD2
- 11-Dehydroprostaglandin F2alpha
- 11 Dehydroprostaglandin F2alpha
- F2alpha, 11-Dehydroprostaglandin
|
Below are MeSH descriptors whose meaning is more general than "Prostaglandin D2".
Below are MeSH descriptors whose meaning is more specific than "Prostaglandin D2".
This graph shows the total number of publications written about "Prostaglandin D2" by people in this website by year, and whether "Prostaglandin D2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 3 | 0 | 3 |
| 2007 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prostaglandin D2" by people in Profiles.
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Wallace CH, Oliveros G, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira M. Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model. Life Sci Alliance. 2022 09 27; 5(12).
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Avila JA, Kiprowska M, Jean-Louis T, Rockwell P, Figueiredo-Pereira ME, Serrano PA. PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. Brain Behav. 2020 01; 10(1):e01465.
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Wang H, Cheung F, Stoll AC, Rockwell P, Figueiredo-Pereira ME. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1436-1450.
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Corwin C, Nikolopoulou A, Pan AL, Nunez-Santos M, Vallabhajosula S, Serrano P, Babich J, Figueiredo-Pereira ME. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018 Sep 20; 15(1):272.
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Jean-Louis T, Rockwell P, Figueiredo-Pereira ME. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by a- and ?-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018 02; 62:130-145.
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Figueiredo-Pereira ME, Corwin C, Babich J. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Ann N Y Acad Sci. 2016 Jan; 1363:125-37.
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Flores JJ, Klebe D, Rolland WB, Lekic T, Krafft PR, Zhang JH. PPAR?-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. Neurobiol Dis. 2016 Mar; 87:124-33.
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Shivers KY, Nikolopoulou A, Machlovi SI, Vallabhajosula S, Figueiredo-Pereira ME. PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochim Biophys Acta. 2014 Sep; 1842(9):1707-19.
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Myeku N, Wang H, Figueiredo-Pereira ME. cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. Neurosci Lett. 2012 Oct 11; 527(2):126-31.
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Lee E, Yin Z, Sidoryk-Wegrzynowicz M, Jiang H, Aschner M. 15-Deoxy-?12,14-prostaglandin J2 modulates manganese-induced activation of the NF-?B, Nrf2, and PI3K pathways in astrocytes. Free Radic Biol Med. 2012 Mar 15; 52(6):1067-74.